Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Julius Beer"'
Autor:
Lena Jaki, Sebastian Weigang, Lisa Kern, Stefanie Kramme, Antoni G. Wrobel, Andrea B. Grawitz, Philipp Nawrath, Stephen R. Martin, Theo Dähne, Julius Beer, Miriam Disch, Philipp Kolb, Lisa Gutbrod, Sandra Reuter, Klaus Warnatz, Martin Schwemmle, Steven J. Gamblin, Elke Neumann-Haefelin, Daniel Schnepf, Thomas Welte, Georg Kochs, Daniela Huzly, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat infections in high-risk patients. Here, we report the adaptation of SARS-CoV-
Externí odkaz:
https://doaj.org/article/d61edc8bae2d4d3c8f29f4fd3b6b89ba
Autor:
Tamara Kaleta, Lisa Kern, Samuel Leandro Hong, Martin Hölzer, Georg Kochs, Julius Beer, Daniel Schnepf, Martin Schwemmle, Nena Bollen, Philipp Kolb, Magdalena Huber, Svenja Ulferts, Sebastian Weigang, Gytis Dudas, Alice Wittig, Lena Jaki, Abdou Padane, Adamou Lagare, Mounerou Salou, Egon Anderson Ozer, Ndodo Nnaemeka, John Kofi Odoom, Robert Rutayisire, Alia Benkahla, Chantal Akoua-Koffi, Abdoul-Salam Ouedraogo, Etienne Simon-Lorière, Vincent Enouf, Stefan Kröger, Sébastien Calvignac-Spencer, Guy Baele, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The A.27 SARS-CoV-2 lineage spread globally in 2021 but did not become dominant. Here, the authors show that A.27 shares some mutations in the spike gene that are present in variants of concern, but lacks the D614G mutation, indicating independent ev
Externí odkaz:
https://doaj.org/article/95413bc995ee4d938afb0a7f4c3cfaa7
Autor:
Sebastian Weigang, Jonas Fuchs, Gert Zimmer, Daniel Schnepf, Lisa Kern, Julius Beer, Hendrik Luxenburger, Jakob Ankerhold, Valeria Falcone, Janine Kemming, Maike Hofmann, Robert Thimme, Christoph Neumann-Haefelin, Svenja Ulferts, Robert Grosse, Daniel Hornuss, Yakup Tanriver, Siegbert Rieg, Dirk Wagner, Daniela Huzly, Martin Schwemmle, Marcus Panning, Georg Kochs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization.
Externí odkaz:
https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee
Autor:
Julius Beer, Stefania Crotta, Angele Breithaupt, Annette Ohnemus, Jan Becker, Benedikt Sachs, Lisa Kern, Miriam Llorian, Nadine Ebert, Fabien Labroussaa, Tran Thi Nhu Thao, Bettina Salome Trueeb, Joerg Jores, Volker Thiel, Martin Beer, Jonas Fuchs, Georg Kochs, Andreas Wack, Martin Schwemmle, Daniel Schnepf
Publikováno v:
Beer, Julius; Crotta, Stefania; Breithaupt, Angele; Ohnemus, Annette; Becker, Jan; Sachs, Benedikt; Kern, Lisa; Llorian, Miriam; Ebert, Nadine; Labroussaa, Fabien; Nhu Thao, Tran Thi; Trueeb, Bettina Salome; Jores, Joerg; Thiel, Volker; Beer, Martin; Fuchs, Jonas; Kochs, Georg; Wack, Andreas; Schwemmle, Martin and Schnepf, Daniel (2022). Impaired immune response drives age-dependent severity of COVID-19. The Journal of experimental medicine, 219(12) Rockefeller Univ. Press 10.1084/jem.20220621
SARS-CoV-2 is a highly contagious respiratory virus and the causative agent for COVID-19. The severity of disease varies from mildly symptomatic to lethal and shows an extraordinary correlation with increasing age, which represents the major risk fac
Publikováno v:
Industrial & Engineering Chemistry Research. 59:19736-19750
Tracer experiments were conducted in a lab-scale cold flow model of 0.4 m by 0.2 m in cross section to investigate the solid mixing behavior of bubbling fluidized beds under continuous particle exc...
Autor:
Iebe Rossey, Sandrine Vanmarcke, Sieglinde De Cae, Joana Rocha-Pereira, Xavier Saelens, Martin Schwemmle, Wander Van Breedam, Andrew Popplewell, Nick Devoogdt, Laurens Liesenborghs, Dominique Tersago, Annette Ohnemus, Kenny Roose, Simon Devos, Julius Beer, Piet Maes, Frank Peelman, Daniel Schnepf, Peter Staeheli, Sofie Jacobs, Wim Nerinckx, Massimiliano Germani, Catelijne Stortelers, George D. Moschonas, Kevin Brady, Alison Turner, Rana Abdelnabi, Daria Fijalkowska, Wannes Weyts, Isabel Remory, Leen Delang, Lana Langendries, Laura Seldeslachts, João Paulo Portela Catani, Bruno Dombrecht, Dries Van Herpe, Dirk Jochmans, Loes van Schie, Koen Sedeyn, Greetje Vande Velde, Chiara Lonigro, Sarah Creytens, Xin Zhang, Bert Schepens, Sebastiaan ter Horst, Kai Dallmeier, Hannah Eeckhaut, Caroline Shi-Yan Foo, Jimmy Borloo, Robbert Boudewijns, Suzanne J.F. Kaptein, James Heads, Nico Callewaert, Birgit Weynand, Mark Ellis, Ana Filipa Oliveira, Annelies Van Hecke, Gitte Michielsen, Dorien De Vlieger, Jackeline Cecilia Zavala Marchan, Alistair Henry, Johan Neyts, Hendrik Jan Thibaut
Publikováno v:
SCIENCE TRANSLATIONAL MEDICINE
Broadly neutralizing antibodies are an important treatment for individuals with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibody-based therapeutics are also essential for pandemic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3830e9b60d433a409a79548892804d43
https://lirias.kuleuven.be/handle/123456789/682263
https://lirias.kuleuven.be/handle/123456789/682263
Autor:
Julius Beer, Marcus Panning, Robert Thimme, Janine Kemming, Lisa Kern, Daniela Huzly, Valeria Falcone, Jakob Ankerhold, Siegbert Rieg, Daniel Hornuss, Yakup Tanriver, Svenja Ulferts, Martin Schwemmle, Robert Grosse, Georg Kochs, Jonas Fuchs, Hendrik Luxenburger, Dirk Wagner, Gert Zimmer, Daniel Schnepf, Maike Hofmann, Christoph Neumann-Haefelin, Sebastian Weigang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Weigang, Sebastian; Fuchs, Jonas; Zimmer, Gert; Schnepf, Daniel; Kern, Lisa; Beer, Julius; Luxenburger, Hendrik; Ankerhold, Jakob; Falcone, Valeria; Kemming, Janine; Hofmann, Maike; Thimme, Robert; Neumann-Haefelin, Christoph; Ulferts, Svenja; Grosse, Robert; Hornuss, Daniel; Tanriver, Yakup; Rieg, Siegbert; Wagner, Dirk; Huzly, Daniela; ... (2021). Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants. Nature Communications, 12(1), p. 6405. Springer Nature 10.1038/s41467-021-26602-3
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Weigang, Sebastian; Fuchs, Jonas; Zimmer, Gert; Schnepf, Daniel; Kern, Lisa; Beer, Julius; Luxenburger, Hendrik; Ankerhold, Jakob; Falcone, Valeria; Kemming, Janine; Hofmann, Maike; Thimme, Robert; Neumann-Haefelin, Christoph; Ulferts, Svenja; Grosse, Robert; Hornuss, Daniel; Tanriver, Yakup; Rieg, Siegbert; Wagner, Dirk; Huzly, Daniela; ... (2021). Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants. Nature Communications, 12(1), p. 6405. Springer Nature 10.1038/s41467-021-26602-3
The origin of SARS-CoV-2 variants of concern remains unclear. Here, we test whether intra-host virus evolution during persistent infections could be a contributing factor by characterizing the long-term SARS-CoV-2 infection dynamics in an immunosuppr
Autor:
Martin Schwemmle, Guy Baele, Georg Kochs, Etienne Simon-Loriere, Sebastian Weigang, Martin Hölzer, Samuel L. Hong, Julius Beer, Jonas Fuchs, Mounerou Salou, Alice Wittig, Philipp Kolb, Lisa Kern, Stefan Kröger, Adamou Lagare, Abdou Padane, Ndodo Nnaemeka, Magdalena Huber, Gytis Dudas, Lena Jaki, Svenja Ulferts, Daniel Schnepf, Abdoul-Salam Ouédraogo, Egon Ozer, Alia Benkahla, Tamara Kaleta, Sébastien Calvignac-Spencer, Vincent Enouf, Robert Rutayisire, Nena Bollen, John Odoom, Marcus Panning, Chantal Akoua-Koffi
Publikováno v:
Nature communications. 13(1)
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic ana
Autor:
Desiree I. Frecot, Daniel Schnepf, Philipp D. Kaiser, Nicole Schneiderhan-Marra, Ulrich Rothbauer, Julius Beer, Martin Schwemmle, Teresa R Wagner, Natalia Ruetalo, Karin Klingel, Michael Schindler, Matthias Becker, Annette Ohnemus, Daniel Junker, Martina Sauter, Bjoern Traenkle
The ongoing COVID-19 pandemic and the frequent emergence of new SARS-CoV-2 variants of concern (VOCs), requires continued development of fast and effective therapeutics. Recently, we identified high-affinity neutralizing nanobodies (Nb) specific for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5426b0202f99084af7fb925a698b5a3c
https://doi.org/10.1101/2021.08.08.455562
https://doi.org/10.1101/2021.08.08.455562
Autor:
Valeria Falcone, Marcus Panning, Lisa Kern, Gert Zimmer, Maike Hofmann, Dirk Wagner, Julius Beer, Daniel Hornuss, Hendrik Luxenburger, Christoph Neumann-Haefelin, Sebastian Weigang, Janine Kemming, Siegbert Rieg, Jonas Fuchs, Yakup Tanriver, Jakob Ankerhold, Georg Kochs, Svenja Ulferts, Daniel Schnepf, Daniela Huzly, Robert Thimme, Robert Grosse, Martin Schwemmle
The recent emergence of SARS-CoV-2 variants showing increased transmissibility and immune escape is a matter of global concern. Their origin remains unclear, but intra-host virus evolution during persistent infections could be a contributing factor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55174d1727abedc483b2a2273eafbfde
https://doi.org/10.1101/2021.04.30.21256244
https://doi.org/10.1101/2021.04.30.21256244