Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Julius, Sipilä"'
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Publikováno v:
Biopolymers. 91(10)
A structure-based comparison of the ligand-binding domains of 35 nuclear receptors from five different subfamilies is presented. Their ligand and coactivator binding sites are characterized using knowledge-based contact preference fields for hydropho
Autor:
Päivi Toivonen, Moshe Finel, Sanna Kaivosaari, Olli Aitio, Julius Sipilä, Jarmo S. Salonen, Mikko Koskinen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(8)
Medetomidine is a chiral imidazole derivate whose dextroenantiomer is pharmacologically active. The major metabolic pathway of dexmedetomidine [(+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole] in humans is N-glucuronidation at the imidazolate ni
Autor:
Julius Sipilä, Jouni Hirvonen, Jari Yli-Kauhaluoma, Jyrki Taskinen, Harri Nurmi, Ann Marie Kaukonen
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 25(4-5)
Currently there are several compounds used as drugs or studied as new chemical entities, which have an electron withdrawing group connected to a vinylic double bond in a phenolic or catecholic core structure. These compounds share a common feature--c
Publikováno v:
Journal of chemical information and computer sciences. 43(5)
Three-dimensional QSAR models were developed for predicting kinetic Michaelis constant (K(m)) values for phenolic substrates of human catecholamine sulfating sulfotransferase (SULT1A3). The K(m) values were correlated to the steric and electronic mol