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pro vyhledávání: '"Julio Sequera"'
Autor:
Franklin Vargas, Julio Sequera, Alberto Fuentes, Mait Velásquez, Hisbeth Mendez, Rafael Medina, Germán Fraile
Publikováno v:
Toxicology in Vitro. 12:661-667
Our approach to assessing the photobiological risk of drugs combines photochemical and physicochemical studies with in vitro testing on human serum, human erythrocytes, lymphocytes and neutrophils. We have used this approach to investigate the photob
Autor:
Franklin Vargas, Ingert Martinez Volkmar, Julio Sequera, Jenny Rojas, Rafael Medina, Germán Fraile, Mait Velásquez, Hisbeth Mendez
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 42:219-225
The phototoxic diuretic drug furosemide (1), a 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)-amino] benzoic acid is photolabile under aerobic and anaerobic conditions. Irradiation of a methanol solution of 1 under oxygen produces photoproducts 2, 3