Adipocitocinas: implicaciones en el pronóstico y tratamiento farmacológico de patología cardiovascular

Autor: M.A. Torres, Julio Moratinos, María Carmen Iglesias-Osma, María José García-Barrado

Publikováno v: Revista Clínica Española. 208:239-246

Las adipocitocinas, factores derivados del tejido graso con propiedades reguladoras, estan implicadas en la fisiopatologia de procesos ateromatosos y metabolicos tales como: cardiopatia isquemica, resistencia a la insulina, obesidad, dislipidemia y d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c587b32fa1771ecec8e0fd2409ce407
https://doi.org/10.1157/13119918

Methylamine but not mafenide mimics insulin-like activity of the semicarbazide-sensitive amine oxidase-substrate benzylamine on glucose tolerance and on human adipocyte metabolism

Autor: Gemma Enrique-Tarancón, María Carmen Iglesias-Osma, Sandy Bour, Philippe Valet, V. Visentin, Luc Marti, María José García-Barrado, Xavier Testar, Maria Francisca Pastor, Julio Moratinos, Christian Carpéné

Publikováno v: Pharmacological Research. 52:475-484

It has been reported that benzylamine reduces blood glucose in rabbits, stimulates hexose uptake, and inhibits lipolysis in mouse, rabbit, and human adipocytes. In the presence of vanadate, benzylamine is also able to improve glucose disposal in norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a000c5f0fd5458c0def8aa56aabfc83e
https://doi.org/10.1016/j.phrs.2005.07.008

Effects of salbutamol and BRL 37344 on diastolic arterial blood pressure, plasma glucose and plasma lactate in rabbits

Autor: M. Reverte, Julio Moratinos

Publikováno v: Fundamental & Clinical Pharmacology. 8:417-424

The aim of this study was to investigate in rabbits the diastolic arterial blood pressure, plasma glucose and plasma lactate responses to salbutamol (a selective beta-2 adrenoceptor agonist) and BRL 37344 (a selective beta-3 adrenoceptor agonist) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4513d5cb3c8d17e04bcd49a8fc01c64
https://doi.org/10.1111/j.1472-8206.1994.tb00820.x

Differential sensitivity to adrenergic stimulation underlies the sexual dimorphism in the development of diabetes caused by Irs-2 deficiency

Autor: María Carmen Iglesias-Osma, María José García-Barrado, Silvia Sanz Gonzalez, Julio Moratinos, Deborah J. Burks, José Carretero, Maria Francisca Pastor Mansilla, Veronica Moreno-Viedma

Publikováno v: BIOCHEMICAL PHARMACOLOGY
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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The diabetic phenotype caused by the deletion of insulin receptor substrate-2 (lrs-2) in mice displays a sexual dimorphism. Whereas the majority of male Irs-2(-/-) mice are overtly diabetic by 12 weeks of age, female Irs-2(-/-) animals develop mild o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e25539e269fa4458c40366b5a60db5
https://pubmed.ncbi.nlm.nih.gov/20959116

Role of Ca2+ channel blockers in insulin secretion resulting from α1- and β-adrenoceptor stimulation in the rabbit

Autor: María José García-Barrado, Julio Moratinos, Maruja Reverte

Publikováno v: European Journal of Pharmacology. 219:461-464

In conscious fasted rabbits the i.v. infusion of amidephrine (alpha 1-agonist) or isoprenaline (beta-agonist) induced an increase in plasma levels of immunoreactive insulin. The alpha 1-mediated response was suppressed in animals pretreated with calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4468a44547e503b8237d7979177a01
https://doi.org/10.1016/0014-2999(92)90489-q