Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA2α/COX-1 Pathway

Autor: Alma M. Astudillo, Juan P. Rodríguez, Carlos Guijas, Julio M. Rubio, María A. Balboa, Jesús Balsinde

Publikováno v: Cells, Vol 10, Iss 2, p 447 (2021)

Macrophages are professional antigen presenting cells with intense phagocytic activity, strategically distributed in tissues and cavities. These cells are capable of responding to a wide variety of innate inflammatory stimuli, many of which are signa

Externí odkaz: https://doaj.org/article/cc21c5731ee94d8ab7e1759328b2e797

Regulation of Phagocytosis in Macrophages by Membrane Ethanolamine Plasmalogens

Autor: Julio M. Rubio, Alma M. Astudillo, Javier Casas, María A. Balboa, Jesús Balsinde

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface

Externí odkaz: https://doaj.org/article/4d17c8110cf34428a498f595c810480b

Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes

Autor: Carlos Guijas, Gema Pérez-Chacón, Alma M. Astudillo, Julio M. Rubio, Luis Gil-de-Gómez, María A. Balboa, Jesús Balsinde

Publikováno v: Journal of Lipid Research, Vol 53, Iss 11, Pp 2343-2354 (2012)

Exposure of human peripheral blood monocytes to free arachidonic acid (AA) results in the rapid induction of lipid droplet (LD) formation by these cells. This effect appears specific for AA in that it is not mimicked by other fatty acids, whether sat

Externí odkaz: https://doaj.org/article/972e8bb48fc5453a97423f19263ea658

Sequestration of 9-Hydroxystearic Acid in FAHFA (Fatty Acid Esters of Hydroxy Fatty Acids) as a Protective Mechanism for Colon Carcinoma Cells to Avoid Apoptotic Cell Death

Autor: Juan Pablo Rodríguez, Alma M. Astudillo, Julio M. Rubio, Jesús Balsinde, María A. Balboa, Carlos Guijas

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cancers
Cancers, 2019, vol. 11, no. 524, p. 1-15.
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
Universidad Nacional del Nordeste
instacron:UNNE
Digital.CSIC. Repositorio Institucional del CSIC
Volume 11
Issue 4
Cancers, Vol 11, Iss 4, p 524 (2019)

Hydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through mechanisms involving different targets. Using mass spectrometry-based l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba0f5c6fc28b3bf2f47cc00d5077220
https://doi.org/10.3390/cancers11040524

Characterization of a second functional gene cluster for the catabolism of phenylacetic acid in Pseudomonas sp. strain Y2

Autor: Victoria Mascaraque, David Bartolomé-Martín, Esteban Martínez-García, Sergio Alonso, Julio M. Rubio, Julián Perera

Publikováno v: Gene. 341:167-179

Pseudomonas sp. strain Y2 is a styrene degrading bacterium that mineralises this compound through its oxidation to phenylacetic acid (PAA). We previously identified a complete gene cluster (paa1 cluster) for the degradation of phenylacetate, but, sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6081610a537028841e3538d55e8dc9
https://doi.org/10.1016/j.gene.2004.06.042