Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Julio M. Rios de la Rosa"'
Autor:
Arianna Gennari, Julio M. Rios de la Rosa, Erwin Hohn, Maria Pelliccia, Enrique Lallana, Roberto Donno, Annalisa Tirella, Nicola Tirelli
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 2594-2608 (2019)
This study is about linking preparative processes of nanoparticles with the morphology of the nanoparticles and with their efficiency in delivering payloads intracellularly. The nanoparticles are composed of hyaluronic acid (HA) and chitosan; the for
Externí odkaz:
https://doaj.org/article/6c810137231e4d0e90644af28977b353
Autor:
Roberto Donno, Erwin Hohn, Maria Pelliccia, Nicola Tirelli, Arianna Gennari, Julio M. Rios de la Rosa, Annalisa Tirella, Enrique Lallana
Publikováno v:
Gennari, A, Rios de la Rosa, J M, Hohn, E, Pelliccia, M, Lallana, E, Donno, R, Tirella, A & Tirelli, N 2019, ' The different ways to chitosan/hyaluronic acid nanoparticles: templated vs. direct complexation. Influence of particle preparative processes on morphology, cell uptake and silencing efficiency ', Beilstein Journal of Nanotechnology, vol. 2019, no. 10, pp. 2594–2608 . https://doi.org/10.3762/bjnano.10.250
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 2594-2608 (2019)
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 2594-2608 (2019)
This study is about linking preparative processes of nanoparticles with the morphology of the nanoparticles and with their efficiency in delivering payloads intracellularly. The nanoparticles are composed of hyaluronic acid (HA) and chitosan; the for
Autor:
Marianne Ashford, Ian J. Stratford, Julio M. Rios de la Rosa, Alice Spadea, Nicola Tirelli, Manal Mehibel, Annalisa Tirella, Kaye J. Williams
Publikováno v:
Molecular Pharmaceutics. 16:2481-2493
The development of delivery systems capable of tumor targeting represents a promising strategy to overcome issues related to nonspecific effects of conventional anticancer therapies. Currently, one of the most investigated agents for cancer targeting
Autor:
Alice Spadea, Julio M. Rios de la Rosa, Roberto Donno, Patrick T. Caswell, Yu Lu, Marianne Ashford, M. Jayne Lawrence, Enrique Lallana, Nicola Tirelli, Sanyogitta Puri
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Spadea, A, Lallana-Ozores, E, Rios De La Rosa, J M, Donno, R, Lawrence, J, Tirelli, N, Ashford, M, Caswell, P, Puri, S & Lu, Y 2020, ' Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines ', Scientific Reports, vol. 10, 14505 . https://doi.org/10.1038/s41598-020-71396-x
Scientific Reports
Spadea, A, Lallana-Ozores, E, Rios De La Rosa, J M, Donno, R, Lawrence, J, Tirelli, N, Ashford, M, Caswell, P, Puri, S & Lu, Y 2020, ' Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines ', Scientific Reports, vol. 10, 14505 . https://doi.org/10.1038/s41598-020-71396-x
Funder: AstraZeneca; doi: http://dx.doi.org/10.13039/100004325
Funder: University of Manchester; doi: http://dx.doi.org/10.13039/501100000770
This study is about fine tuning the targeting capacity of peptide-decorated nanoparticles to discr
Funder: University of Manchester; doi: http://dx.doi.org/10.13039/501100000770
This study is about fine tuning the targeting capacity of peptide-decorated nanoparticles to discr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5915ed4106a70f39b6f7c6275f2fba1
https://www.repository.cam.ac.uk/handle/1810/309839
https://www.repository.cam.ac.uk/handle/1810/309839
Autor:
Arianna Gennari, Julio M. Rios de la Rosa, Richard d'Arcy, Enrique Lallana, Roberto Donno, Marianne Ashford, Hill Kathryn Jane, Kevin Treacher, Nicola Tirelli
Publikováno v:
Donno, R, Gennari, A, Lallana, E, De La Rosa, J M R, d'Arcy, R, Treacher, K, Hill, K, Ashford, M & Tirelli, N 2017, ' Nanomanufacturing through microfluidic-assisted nanoprecipitation : Advanced analytics and structure-activity relationships ', International Journal of Pharmaceutics, vol. 534, no. 1-2, pp. 97-107 . https://doi.org/10.1016/j.ijpharm.2017.10.006
We have employed microfluidics (cross-shaped chip) for the preparation of drug-loaded poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles. The polymer precipitates from an acetone solution upon its controlled laminar mixing (flow focusing) with a
Publikováno v:
Tirella, A, Rios De La Rosa, J M & Tirelli, N 2019, ' Hyaluronic acid carrier-cell interactions: a tri-culture model of the tumour microenvironment to study siRNA delivery under flow conditions ', International Journal of Nano and Biomaterials, vol. 8, no. 2 . https://doi.org/10.1504/IJNBM.2019.101755
CD44 is often over expressed in solid tumours, rendering this protein a 'hot' target in drug delivery. As CD44 is the main surface receptor of hyaluronic acid (HA), one of the most common therapeutic approaches consists of hijacking the cell's mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f095d18ffd29039ddeea8ae6895b94
https://www.research.manchester.ac.uk/portal/en/publications/hyaluronic-acid-carriercell-interactions-a-triculture-model-of-the-tumour-microenvironment-to-study-sirna-delivery-under-flow-conditions(0b5c4032-a3f3-4643-aff3-98b2fab86c49).html
https://www.research.manchester.ac.uk/portal/en/publications/hyaluronic-acid-carriercell-interactions-a-triculture-model-of-the-tumour-microenvironment-to-study-sirna-delivery-under-flow-conditions(0b5c4032-a3f3-4643-aff3-98b2fab86c49).html
Autor:
Alice Spadea, Nicola Tirelli, Arianna Gennari, Julio M. Rios de la Rosa, Maria Pelliccia, Enrique Lallana, Annalisa Tirella, Walter Rocchia, Ian J. Stratford, Ponpawee Pingrajai
Publikováno v:
Rios De La Rosa, J M, Pingrajai, P, Pelliccia, M, Spadea, A, Lallana-Ozores, E, Gennari, A, Stratford, I, Rocchia, W, Tirella, A & Tirelli, N 2019, ' Binding and internalization in receptor-targeted carriers. The complex role of CD44 in the uptake of hyaluronic acid-based nanoparticles (siRNA delivery) ', Advanced Healthcare Materials, vol. 8, no. 24, 1901182 . https://doi.org/10.1002/adhm.201901182
This paper is about the actual role of CD44 in the perspective of a hyaluronic acid (HA)-based, targeted therapy. CD44 is the main HA receptor: it is present both in healthy and cancerous cells, but is overexpressed in many carcinomas, with important
Publikováno v:
Rios De La Rosa, J M, Tirella, A & Tirelli, N 2018, ' Receptor-Targeted Drug Delivery and the (Many) Problems We Know of: The Case of CD44 and Hyaluronic Acid ', Advanced Biosystems . https://doi.org/10.1002/adbi.201800049
CD44 is best known for being the most common receptor of hyaluronic acid (HA). It is also a heterogeneous molecule: while its standard isoform (CD44s) is ubiquitously expressed, there are also a range of variants (CD44v), and both CD44s and CD44v und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df6c45f1de5ab80b242da02adc6f0a7
https://www.research.manchester.ac.uk/portal/en/publications/receptortargeted-drug-delivery-and-the-many-problems-we-know-of-the-case-of-cd44-and-hyaluronic-acid(646a840c-92db-419b-a508-ddb703757353).html
https://www.research.manchester.ac.uk/portal/en/publications/receptortargeted-drug-delivery-and-the-many-problems-we-know-of-the-case-of-cd44-and-hyaluronic-acid(646a840c-92db-419b-a508-ddb703757353).html
Autor:
Sanyogitta Puri, Maria Pelliccia, Arianna Gennari, Marianne Ashford, Julio M. Rios de la Rosa, Annalisa Tirella, Ian J. Stratford, Nicola Tirelli, Enrique Lallana
Publikováno v:
Molecular pharmaceutics. 14(7)
Chitosan/hyaluronic acid (HA) nanoparticles can be used to deliver an RNA/DNA cargo to cells overexpressing HA receptors such as CD44. For these systems, unequivocal links have not been established yet between chitosan macromolecular (molecular weigh
Autor:
Patrick J. Merkling, María Jesús Sayagués, Julio M. Rios de la Rosa, Ana Paula Zaderenko, José Antonio Sánchez-Alcázar, José M. Oliva
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Oliva, J M, Ríos De La Rosa, J M, Sayagués, M J, Sánchez-Alcázar, J A, Merkling, P J & Zaderenko, A P 2017, ' Solvent-assisted in situ synthesis of cysteamine-capped silver nanoparticles ', Advances in Natural Sciences: Nanoscience and Nanotechnology, vol. 9, no. 1, 015001 . https://doi.org/10.1088/2043-6254/aa9de9
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Oliva, J M, Ríos De La Rosa, J M, Sayagués, M J, Sánchez-Alcázar, J A, Merkling, P J & Zaderenko, A P 2017, ' Solvent-assisted in situ synthesis of cysteamine-capped silver nanoparticles ', Advances in Natural Sciences: Nanoscience and Nanotechnology, vol. 9, no. 1, 015001 . https://doi.org/10.1088/2043-6254/aa9de9
Silver nanoparticles offer a huge potential for biomedical applications owing to their exceptional properties and small size. Specifically, cysteamine-capped silver nanoparticles could form the basis for new anticancer therapies combining the cytotox