Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Julio C. Castro-Palomino"'
Autor:
Jordi Sanahuja, Montse Erra, Nuria Godessart, Raquel F. Reinoso, Estrella Lozoya, Imma Moreno, Pilar Pizcueta, Julio C. Castro-Palomino, Miriam Andrés
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7268-7272
The structure–activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHOD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490de3d4ae27fb547cdd503041c2caad
https://doi.org/10.1016/j.bmcl.2011.10.052
https://doi.org/10.1016/j.bmcl.2011.10.052
Autor:
Yongsheng Chen, Mark Santos, Emily Lin, Stacy Markison, John E. Tellew, Sandra M. Lechner, Maria Prat, Xiaohu Zhang, John Saunders, Silvia Gual, Marion Lanier, Marı´a I. Crespo, John P. Williams, Raymond S. Gross, Tanya Joswig, Jaimie K. Rueter, Deborah H. Slee, Siobhan Malany, Jose-Luis Diaz, Manisha Moorjani, Julio C. Castro-Palomino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1778-1783
A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A(2A) antagonists is described. SAR studies led to compound 14 with excellent potency (K(i) = 0.4 nM), selectivity (A(1)/A(2A) > 100), and efficacy (MED 10 mg/kg p.o.) in the rat haloperidol-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dca2261358c58ec30c26ccccacb9f1
https://doi.org/10.1016/j.bmcl.2008.02.032
https://doi.org/10.1016/j.bmcl.2008.02.032
Publikováno v:
Tetrahedron Letters. 41:629-632
N-Thiodiglycoloyl (TDG) protection of O-acetylated glucosamine could be readily carried out with thiodiglycolic anhydride and then treatment with acetic anhydride in pyridine. Ensuing reaction with hydrazinium acetate and then base-catalyzed activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de78f6cdc0d513f3a4c2d61811521cc
https://doi.org/10.1016/s0040-4039(99)02136-x
https://doi.org/10.1016/s0040-4039(99)02136-x
Publikováno v:
Pure and Applied Chemistry. 71:729-744
Glycoside bond formation generally requires activation of the sugar at the anomeric center. To this end, anomeric oxygen exchange reactions, resulting in the Koenigs-Knorr method and variations or, alternatively, activation through retention of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6681313dd301018850a0de3732cc9aef
https://doi.org/10.1351/pac199971050729
https://doi.org/10.1351/pac199971050729
Autor:
El-Sayed I. Ibrahim, El-Sayed H. El-Ashry, Julio C. Castro-Palomino, Richard R. Schmidt, Mohamed R. E. Aly
Publikováno v:
European Journal of Organic Chemistry. 1998:2305-2316
Glucosamine was readily transformed into N-dimethylmaleoyl (DMM) protected derivative 1 which furnished trichloroacetimidate 4 as glycosyl donor. Reaction with various acceptors (5a–g) in the presence of TMSOTf as the catalyst afforded the correspo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2ff609cae6ea7f70aa867dfe1f5c47
https://doi.org/10.1002/(sici)1099-0690(199811)1998:11<2305::aid-ejoc2305>3.0.co
https://doi.org/10.1002/(sici)1099-0690(199811)1998:11<2305::aid-ejoc2305>3.0.co
Publikováno v:
Journal of the American Chemical Society. 120:5434-5440
Synthesis of Neu5Acα(2−3)Galβ(1−4)Glc and Neu5Acα(2−8)Neu5Ac derivatives 12α and 14α, from lactose derivative 6 and 2,3-dehydro-Neu5Ac derivative 7, respectively, with anchimerically assisted Neu5Ac donor 3e, 3f, or 3g has been studied. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cd4cbde418974cb7298ef03c11f86d6
https://doi.org/10.1021/ja9740327
https://doi.org/10.1021/ja9740327
Autor:
Richard R. Schmidt, Lloyd J. Old, Stefan Reinhardt, Gerd Ritter, Julio C. Castro-Palomino, Sheila R. Fortunato
Publikováno v:
Angewandte Chemie International Edition in English. 36:1998-2001
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d13e828bc27e2966ea9008f358bc074
https://doi.org/10.1002/anie.199719981
https://doi.org/10.1002/anie.199719981
Autor:
Gerd Ritter, Lloyd J. Old, Stefan Reinhardt, Richard R. Schmidt, Julio C. Castro-Palomino, Sheila R. Fortunato
Publikováno v:
Angewandte Chemie. 109:2081-2085
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c898d507115195ff02646fb0eba2e02c
https://doi.org/10.1002/ange.19971091820
https://doi.org/10.1002/ange.19971091820
Publikováno v:
Tetrahedron Letters. 38:6837-6840
2-O-Unprotected and 2-deoxy-2,3-dehydro-neuraminic acid derivatives 2, 4, and 10 exhibit enhanced acceptor properties at their 8-hydroxy group in sialylation reactions with phosphite 5 as donor; yet, mainly (10) or exclusively (2, 4) β-glycoside bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::215de40ad03e3b8bc69306d0131479bb
https://doi.org/10.1016/s0040-4039(97)01620-1
https://doi.org/10.1016/s0040-4039(97)01620-1
Publikováno v:
Liebigs Annalen. 1996:1623-1626
The N-tetrachlorophthalimido-protected glucosamine donor 2 reacts with electron-rich phenol ethers 3a–c to afford aryl C-glycosides 4a–c. The N-tetrachlorophthaloyl group could be readily removed by sodium borohydride treatment and then phthalide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa6e051750b536902661fb5d052b532b
https://doi.org/10.1002/jlac.199619961019
https://doi.org/10.1002/jlac.199619961019