Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Julio Aguirre Ghiso"'
Autor:
Jeffrey L. Benovic, Julio Aguirre-Ghiso, Andrew E. Aplin, Philip B. Wedegaertner, Naiming Zhou, Gregory G. Tall, Takami Sato, Mizue Terai, Shihua Wu, Lihong Zhang, Thomas H. Charpentier, Dougan McGrath, Timothy J. Purwin, Clinita E. Randolph, Eduardo Farias, Dominic Lapadula
GNAQ and GNA11 sequence analysis of UM002B cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc86c2aecfa02c9d2318332d673c3913
https://doi.org/10.1158/1541-7786.22513482.v1
https://doi.org/10.1158/1541-7786.22513482.v1
Supplementary Figures 1-5 from Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma
Autor:
Andrew E. Aplin, Julio Aguirre-Ghiso, Michael A. Davies, Takami Sato, Nelisa Bechtel, Connie Liao, Usman Baqai, Prem Patel, Vivian Chua, Anna Han, Timothy J. Purwin, Jessica L.F. Teh
Supplemental Figure 1. CDK4/6i + MEKi treatment does not modulate proteins within the apoptotic signaling pathway. Supplemental Figure 2. Growth of UM001 xenografts treated with MEKi and/or CDK4/6i. Supplemental Figure 3. RNA-seq samples cluster base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85006f5b1b7ea2fe04bccacbd4f5ada8
https://doi.org/10.1158/1535-7163.22521028
https://doi.org/10.1158/1535-7163.22521028
Autor:
Andrew E. Aplin, Julio Aguirre-Ghiso, Michael A. Davies, Takami Sato, Nelisa Bechtel, Connie Liao, Usman Baqai, Prem Patel, Vivian Chua, Anna Han, Timothy J. Purwin, Jessica L.F. Teh
Supplemental Table 1. RNA Seq z-score values for genes significantly up- or downregulated in MEKi-R or CDK4/6i-T groups compared to controls, corresponding to figure 3A. Data are indexed to show which genes are significant for each comparison (BHFDR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010561c8e09e98e68d8256516c17c305
https://doi.org/10.1158/1535-7163.22521025.v1
https://doi.org/10.1158/1535-7163.22521025.v1
Autor:
Andrew E. Aplin, Julio Aguirre-Ghiso, Michael A. Davies, Takami Sato, Nelisa Bechtel, Connie Liao, Usman Baqai, Prem Patel, Vivian Chua, Anna Han, Timothy J. Purwin, Jessica L.F. Teh
Frequent GNAQ and GNA11 mutations in uveal melanoma hyperactivate the MEK–ERK signaling pathway, leading to aberrant regulation of cyclin-dependent kinases (CDK) and cell-cycle progression. MEK inhibitors (MEKi) alone show poor efficacy in uveal me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8060e37103f45fc1d0c5ac98b19764a9
https://doi.org/10.1158/1535-7163.c.6542872
https://doi.org/10.1158/1535-7163.c.6542872
Autor:
Doris Germain, Samuel Waxman, Toshi Shioda, Julio Aguirre-Ghiso, Zhenyu Yue, Urvashi Bahadur, Luena Papa, Yuki Ishii
Purpose: Fulvestrant is known to promote the degradation of the estrogen receptor (ER) in the nucleus. However, fulvestrant also promotes the aggregation of the newly synthesized ER in the cytoplasm. Accumulation of protein aggregates leads to cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d1507793ebffe88080d2a6336fd32d
https://doi.org/10.1158/1078-0432.c.6519534
https://doi.org/10.1158/1078-0432.c.6519534
Autor:
Doris Germain, Samuel Waxman, Toshi Shioda, Julio Aguirre-Ghiso, Zhenyu Yue, Urvashi Bahadur, Luena Papa, Yuki Ishii
Supplementary Figure S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f84fcb6ffe9a0e30922f9a41626eecf
https://doi.org/10.1158/1078-0432.22442901.v1
https://doi.org/10.1158/1078-0432.22442901.v1
Autor:
Andrew G. Sikora, Julio Aguirre-Ghiso, Yeriel Estrada, Elizabeth A. Grimm, Jerry E. Chipuk, Denái R. Milton, Sudeh Izadmehr, Suhendan Ekmekcioglu, Michael A. Davies, Falguni Parikh, Padmini Jayaraman, Esther Lopez-Rivera
PDF file - 76K, In MT-RET-1 mouse melanoma cell line we transient trafected with with siRNA-iNOS human, after 48 hours MT-RET-1 mouse cell lysate were subjected to SDS-PAGE and western blot analysis for iNOS, and actin as a loading control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07af2dc1a465ce322981dbb7d486ea9f
https://doi.org/10.1158/0008-5472.22401572.v1
https://doi.org/10.1158/0008-5472.22401572.v1
Autor:
Andrew G. Sikora, Julio Aguirre-Ghiso, Yeriel Estrada, Elizabeth A. Grimm, Jerry E. Chipuk, Denái R. Milton, Sudeh Izadmehr, Suhendan Ekmekcioglu, Michael A. Davies, Falguni Parikh, Padmini Jayaraman, Esther Lopez-Rivera
PDF file - 67K, A375 cells were treated with L-NIL (300 μM and 1000 μM) or the NO scavenger PTIO (300 μM) for 24 hours prior to harvest and preparation of protein lysates. Western Blot analyses of AKT phosphorylation at serine 473 and total AKT de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7fd9730224e8fd61ebbf341ebf685e
https://doi.org/10.1158/0008-5472.22401566
https://doi.org/10.1158/0008-5472.22401566
Autor:
Andrew G. Sikora, Julio Aguirre-Ghiso, Yeriel Estrada, Elizabeth A. Grimm, Jerry E. Chipuk, Denái R. Milton, Sudeh Izadmehr, Suhendan Ekmekcioglu, Michael A. Davies, Falguni Parikh, Padmini Jayaraman, Esther Lopez-Rivera
PDF file - 77K, A375 cells were cultured with the indicated concentrations of the NO donor S-nitroso-acetyl-penicillamine (SNAP), or the NO scavenger PTIO for 16 Hours prior to harvest and preparation of protein lysates.. Biotin switch assay was perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0922a3174981fb629d2e3502a0fd2edc
https://doi.org/10.1158/0008-5472.22401569
https://doi.org/10.1158/0008-5472.22401569
Autor:
Andrew G. Sikora, Julio Aguirre-Ghiso, Yeriel Estrada, Elizabeth A. Grimm, Jerry E. Chipuk, Denái R. Milton, Sudeh Izadmehr, Suhendan Ekmekcioglu, Michael A. Davies, Falguni Parikh, Padmini Jayaraman, Esther Lopez-Rivera
PDF file - 135K, A375 melanoma cells were exposed for 6 hours or 24 Hours to ODQ (3 uM, 10 uM), or the vehicle control dimethylsulfoxide (DMSO). mTOR pathway activation was analyzed by 4EBP1 and p-S6RP western blot. Signals were quantified by densito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0f05feff8e6ac82602d96027b23da1
https://doi.org/10.1158/0008-5472.22401563
https://doi.org/10.1158/0008-5472.22401563