Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Julio Aguado"'
Autor:
Hannah C. Leeson, Julio Aguado, Cecilia Gómez-Inclán, Harman Kaur Chaggar, Atefah Taherian Fard, Zoe Hunter, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106562- (2024)
Ataxia Telangiectasia (AT) is a rare disorder caused by mutations in the ATM gene and results in progressive neurodegeneration for reasons that remain poorly understood. In addition to its central role in nuclear DNA repair, ATM operates outside the
Externí odkaz:
https://doaj.org/article/b826d148b82f43529a6250e191ea9f40
Autor:
Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio, Fabrizio d’Adda di Fagagna
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism activated in ~10–15% of cancers, characterized by telomeric damage. Telomeric damage-induced long non-coding RNAs (dilncRNAs) are transcribed at dysfunctional t
Externí odkaz:
https://doaj.org/article/96aecb24e77f4ab3b16b729a382e090c
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Aging is a major risk factor for many neurodegenerative diseases. Klotho (KL) is a glycosylated transmembrane protein that is expressed in the choroid plexus and neurons of the brain. KL exerts potent anti-aging effects on multiple cell type
Externí odkaz:
https://doaj.org/article/74fa64d5680d4bdba32351255a2b38ac
Autor:
Ariel Isaacs, Alberto A. Amarilla, Julio Aguado, Naphak Modhiran, Eduardo A. Albornoz, Alireza A. Baradar, Christopher L. D. McMillan, Jovin J. Y. Choo, Adi Idris, Aroon Supramaniam, Nigel A. J. McMillan, David A. Muller, Paul R. Young, Trent M. Woodruff, Ernst J. Wolvetang, Keith J. Chappell, Daniel Watterson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since the start of the COVID-19 pandemic, multiple waves of SARS-CoV-2 variants have emerged. Of particular concern is the omicron variant, which harbors 28 mutations in the spike glycoprotein receptor binding and N-terminal domains relative to the a
Externí odkaz:
https://doaj.org/article/4cb5d30fc1704d60b97006877192104a
Publikováno v:
Viruses, Vol 15, Iss 5, p 1062 (2023)
Zika virus (ZIKV) has a unique ability among flaviviruses to cross the placental barrier and infect the fetal brain causing severe abnormalities of neurodevelopment known collectively as congenital Zika syndrome. In our recent study, we demonstrated
Externí odkaz:
https://doaj.org/article/848bfef229a043c194f1791d2c3e1a40
Autor:
Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson, Fabrizio d’Adda di Fagagna
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Hutchinson–Gilford progeria syndrome causes premature aging. Here the authors show that activation of the DNA damage response at dysfunctional telomeres and transcription of telomeric non-coding RNAs contributes to the pathogenesis, which can be am
Externí odkaz:
https://doaj.org/article/d5eb9edbff7e43f5b790e3b311b3399f
Autor:
Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci, Fabrizio d’Adda di Fagagna
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically m
Externí odkaz:
https://doaj.org/article/1dceda3e3a63458496e0b40a4c34adf3
Autor:
Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci, Fabrizio d’Adda di Fagagna
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-2 (2017)
Nature Communications 8: Article number: 13980 (2017); Published: 27 February 2017; Updated: 13 April 2017 In Supplementary Fig. 3d, the two columns of DAPI images associated with pATM and pS/TQ images were inadvertently swapped. The correct version
Externí odkaz:
https://doaj.org/article/77144d424c1d4421b8601ee38f32f70c
Autor:
Julio Aguado, Alberto Amarilla, Atefeh Taherian Fard, Eduardo Albornoz, Alexander Tyshkovskiy, Marius Schwabenland, Harman Chaggar, Naphak Modhiran, Cecilia Gómez-Inclán, Ibrahim Javed, Alireza Baradar, Benjamin Liang, Malindrie Dharmaratne, Giovanni Pietrogrande, Pranesh Padmanabhan, Morgan Freney, Rhys Parry, Julian Sng, Ariel Isaacs, Alexander Khromykh, Alejandro Rojas-Fernandez, Thomas Davis, Marco Prinz, Bertram Bengsch, Vadim Gladyshev, Trent Woodruff, Jessica Mar, Daniel Watterson, Ernst Wolvetang
Aging is the primary risk factor for most neurodegenerative diseases, and recently coronavirus disease 2019 (COVID-19) has been associated with severe neurological manifestations that can eventually impact neurodegenerative conditions in the long-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58108fcdf5784e9a4fd9efec05003286
https://doi.org/10.1101/2023.01.17.524329
https://doi.org/10.1101/2023.01.17.524329
Autor:
Andrii Slonchak, Xiaohui Wang, Julio Aguado, Julian D. J. Sng, Harman Chaggar, Morgan E. Freney, Kexin Yan, Francisco J. Torres, Alberto A. Amarilla, Rickyle Balea, Yin Xiang Setoh, Nias Peng, Daniel Watterson, Ernst Wolvetang, Andreas Suhrbier, Alexander A. Khromykh
Publikováno v:
Science advances. 8(48)
All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not well define