Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Julio A. Aguirre Ghiso"'
Autor:
Lucia Borriello, Anouchka Coste, Brian Traub, Ved P. Sharma, George S. Karagiannis, Yu Lin, Yarong Wang, Xianjun Ye, Camille L. Duran, Xiaoming Chen, Madeline Friedman, Maria Soledad Sosa, Dan Sun, Erica Dalla, Deepak K. Singh, Maja H. Oktay, Julio A. Aguirre-Ghiso, John S. Condeelis, David Entenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The understanding of the mechanisms underlying the ability of disseminated tumor cells (DTCs) to form metastasis is incomplete. Here, by using high-resolution intravital imaging of the murine lung to track the fate of breast-derived DTCs, the authors
Externí odkaz:
https://doaj.org/article/5970a40bc7bc451f81378de22f3362d1
Autor:
Saul Carcamo, Christie B. Nguyen, Elena Grossi, Dan Filipescu, Aktan Alpsoy, Alisha Dhiman, Dan Sun, Sonali Narang, Jochen Imig, Tiphaine C. Martin, Ramon Parsons, Iannis Aifantis, Aristotelis Tsirigos, Julio A. Aguirre-Ghiso, Emily C. Dykhuizen, Dan Hasson, Emily Bernstein
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110637- (2022)
Summary: ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma; however, its tumor-suppressive mechanisms in the context of the chromatin landscape remain to be elucidated. Here, we model ARID2 deficiency in melanoma cells, which r
Externí odkaz:
https://doaj.org/article/6ee77d1cfbd846c4b902e2327217d8be
Autor:
Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso, Bjørn Naume
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-13 (2018)
Abstract Background The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but cli
Externí odkaz:
https://doaj.org/article/521c5332ad384ee18c83f33a4edd8b9a
Autor:
Nina Linde, Maria Casanova-Acebes, Maria Soledad Sosa, Arthur Mortha, Adeeb Rahman, Eduardo Farias, Kathryn Harper, Ethan Tardio, Ivan Reyes Torres, Joan Jones, John Condeelis, Miriam Merad, Julio A. Aguirre-Ghiso
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Early dissemination of cancer cells has been reported to occur in certain breast cancer models. Here the authors show that intra-epithelial macrophages in the early pre-cancer lesions drive early cancer cell dissemination through Wnt-1 secretion and
Externí odkaz:
https://doaj.org/article/26d917dd15e34f92be68de21ef6a76c2
Autor:
David Lyden, Cyrus M. Ghajar, Ana Luísa Correia, Julio A. Aguirre-Ghiso, Shang Cai, Maria Rescigno, Peiyuan Zhang, Guohong Hu, Sarah-Maria Fendt, Adrienne Boire, Ralph R. Weichselbaum, Rohan R. Katipally
Publikováno v:
Cancer Cell
Metastasis, the major cause of cancer death, represents one of the major challenges in oncology. Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dorm
Autor:
Mitchell E. Fane, Yash Chhabra, Gretchen M. Alicea, Devon A. Maranto, Stephen M. Douglass, Marie R. Webster, Vito W. Rebecca, Gloria E. Marino, Filipe Almeida, Brett L. Ecker, Daniel J. Zabransky, Laura Hüser, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, Meenhard Herlyn, David W. Speicher, Wei Xu, Xiaowei Xu, Elizabeth M. Jaffee, Julio A. Aguirre-Ghiso, Ashani T. Weeraratna
Publikováno v:
Nature
Disseminated cancer cells from primary tumours can seed in distal tissues, but may take several years to form overt metastases, a phenomenon that is termed tumour dormancy. Despite its importance in metastasis and residual disease, few studies have b
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 12, p 2648 (2021)
Prostate cancer has a variable clinical course, ranging from curable local disease to lethal metastatic spread. Eradicating metastatic cells is a unique challenge that is rarely met with the available therapies. Thus, targeting prostate cancer cells
Externí odkaz:
https://doaj.org/article/70b737c259844ec19effa53f09ed5dce
Autor:
Jeffrey L. Benovic, Takami Sato, Andrew E. Aplin, Julio A. Aguirre-Ghiso, Bhavik Modasia, Christian C. Heine, Melisa Lopez-Anton, Rama Kadamb, Eduardo Farias, Ryota Tanaka, Takahito Sugase, Mizue Terai, Bao Lam, Dominic Lapadula
Figure S4: Synergy plots of OCM3 (A), OMM1.3 (B), and UM001 (C) cells treated with YM and PPP or BYL719. Left panels show relative cell number as a percent of untreated control cells (100%) and the right panels show the corresponding Loewe synergy pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7ad50784a5cfc9cb93cdd086b67791
https://doi.org/10.1158/1535-7163.22523797.v1
https://doi.org/10.1158/1535-7163.22523797.v1
Autor:
Julio A. Aguirre-Ghiso, Douglas S. Conklin, Antonis Kourtidis, Shishir Ojha, Aparna C. Ranganathan
Pancreatic endoplasmic reticulum kinase (PERK)-eIF2α signaling, a component of the endoplasmic reticulum (ER) stress response, has been proposed as a therapeutic target due to its importance to cell survival in hypoxic tumors. In this study, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0926b89b92b5c74be37415273bc8e86e
https://doi.org/10.1158/0008-5472.c.6498146.v1
https://doi.org/10.1158/0008-5472.c.6498146.v1
It has been proposed that occult, disseminated metastatic cells are refractory to chemotherapy due to lack of proliferation. We have shown that p38 activation induces dormancy of squamous carcinoma cells. We now show that p38 signaling in these cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a4f787d9ae0e8307bf55632b019dc8
https://doi.org/10.1158/0008-5472.c.6495174
https://doi.org/10.1158/0008-5472.c.6495174