Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Julio A. Aguirre‐Ghiso"'
Autor:
Lucia Borriello, Anouchka Coste, Brian Traub, Ved P. Sharma, George S. Karagiannis, Yu Lin, Yarong Wang, Xianjun Ye, Camille L. Duran, Xiaoming Chen, Madeline Friedman, Maria Soledad Sosa, Dan Sun, Erica Dalla, Deepak K. Singh, Maja H. Oktay, Julio A. Aguirre-Ghiso, John S. Condeelis, David Entenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The understanding of the mechanisms underlying the ability of disseminated tumor cells (DTCs) to form metastasis is incomplete. Here, by using high-resolution intravital imaging of the murine lung to track the fate of breast-derived DTCs, the authors
Externí odkaz:
https://doaj.org/article/5970a40bc7bc451f81378de22f3362d1
Autor:
Saul Carcamo, Christie B. Nguyen, Elena Grossi, Dan Filipescu, Aktan Alpsoy, Alisha Dhiman, Dan Sun, Sonali Narang, Jochen Imig, Tiphaine C. Martin, Ramon Parsons, Iannis Aifantis, Aristotelis Tsirigos, Julio A. Aguirre-Ghiso, Emily C. Dykhuizen, Dan Hasson, Emily Bernstein
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110637- (2022)
Summary: ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma; however, its tumor-suppressive mechanisms in the context of the chromatin landscape remain to be elucidated. Here, we model ARID2 deficiency in melanoma cells, which r
Externí odkaz:
https://doaj.org/article/6ee77d1cfbd846c4b902e2327217d8be
Autor:
Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso, Bjørn Naume
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-13 (2018)
Abstract Background The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but cli
Externí odkaz:
https://doaj.org/article/521c5332ad384ee18c83f33a4edd8b9a
Autor:
Nina Linde, Maria Casanova-Acebes, Maria Soledad Sosa, Arthur Mortha, Adeeb Rahman, Eduardo Farias, Kathryn Harper, Ethan Tardio, Ivan Reyes Torres, Joan Jones, John Condeelis, Miriam Merad, Julio A. Aguirre-Ghiso
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Early dissemination of cancer cells has been reported to occur in certain breast cancer models. Here the authors show that intra-epithelial macrophages in the early pre-cancer lesions drive early cancer cell dissemination through Wnt-1 secretion and
Externí odkaz:
https://doaj.org/article/26d917dd15e34f92be68de21ef6a76c2
Autor:
Chi-Yeh Chung, Zhen Sun, Gavriel Mullokandov, Almudena Bosch, Zulekha A. Qadeer, Esma Cihan, Zachary Rapp, Ramon Parsons, Julio A. Aguirre-Ghiso, Eduardo F. Farias, Brian D. Brown, Alexandre Gaspar-Maia, Emily Bernstein
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 472-486 (2016)
Chromatin-mediated processes influence the development and progression of breast cancer. Using murine mammary carcinoma-derived tumorspheres as a functional readout for an aggressive breast cancer phenotype, we performed a loss-of-function screen tar
Externí odkaz:
https://doaj.org/article/286cd9101ac748d1ab4ec261ff8cbf65
Autor:
Ulrike Begley, Maria Soledad Sosa, Alvaro Avivar‐Valderas, Ashish Patil, Lauren Endres, Yeriel Estrada, Clement T.Y. Chan, Dan Su, Peter C. Dedon, Julio A. Aguirre‐Ghiso, Thomas Begley
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 3, Pp 366-383 (2013)
Abstract Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progressi
Externí odkaz:
https://doaj.org/article/b4fd80b73e0a453d8400f3b919829c05
Autor:
David Lyden, Cyrus M. Ghajar, Ana Luísa Correia, Julio A. Aguirre-Ghiso, Shang Cai, Maria Rescigno, Peiyuan Zhang, Guohong Hu, Sarah-Maria Fendt, Adrienne Boire, Ralph R. Weichselbaum, Rohan R. Katipally
Publikováno v:
Cancer Cell
Metastasis, the major cause of cancer death, represents one of the major challenges in oncology. Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dorm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbac350bc3d9aecf36ca4120e3b50eed
https://doi.org/10.1016/j.ccell.2022.07.010
https://doi.org/10.1016/j.ccell.2022.07.010
Autor:
Mitchell E. Fane, Yash Chhabra, Gretchen M. Alicea, Devon A. Maranto, Stephen M. Douglass, Marie R. Webster, Vito W. Rebecca, Gloria E. Marino, Filipe Almeida, Brett L. Ecker, Daniel J. Zabransky, Laura Hüser, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, Meenhard Herlyn, David W. Speicher, Wei Xu, Xiaowei Xu, Elizabeth M. Jaffee, Julio A. Aguirre-Ghiso, Ashani T. Weeraratna
Publikováno v:
Nature
Disseminated cancer cells from primary tumours can seed in distal tissues, but may take several years to form overt metastases, a phenomenon that is termed tumour dormancy. Despite its importance in metastasis and residual disease, few studies have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75ba0560f3fb3cb1198a0ff0b09452e
https://doi.org/10.1038/s41586-022-04774-2
https://doi.org/10.1038/s41586-022-04774-2
Autor:
Jeffrey L. Benovic, Takami Sato, Andrew E. Aplin, Julio A. Aguirre-Ghiso, Bhavik Modasia, Christian C. Heine, Melisa Lopez-Anton, Rama Kadamb, Eduardo Farias, Ryota Tanaka, Takahito Sugase, Mizue Terai, Bao Lam, Dominic Lapadula
Figure S4: Synergy plots of OCM3 (A), OMM1.3 (B), and UM001 (C) cells treated with YM and PPP or BYL719. Left panels show relative cell number as a percent of untreated control cells (100%) and the right panels show the corresponding Loewe synergy pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7ad50784a5cfc9cb93cdd086b67791
https://doi.org/10.1158/1535-7163.22523797.v1
https://doi.org/10.1158/1535-7163.22523797.v1
Autor:
Julio A. Aguirre-Ghiso, Douglas S. Conklin, Antonis Kourtidis, Aparna C. Ranganathan, Bibiana V. Iglesias, Paloma Bragado, Denis Schewe, Ajish George, Alejandro P. Adam
Supplementary Figure 5 from Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004c2f005f25a24b78fa1ea39409a3c0
https://doi.org/10.1158/0008-5472.22378100
https://doi.org/10.1158/0008-5472.22378100