Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Julio A Camarero"'
Autor:
Frank H Schumann, Ranjani eVaradan, Praveen Pudiavettil Tayakuniyil, Jennifer Hall Grossman, Julio A Camarero, David eFushman
Publikováno v:
Frontiers in Chemistry, Vol 3 (2015)
Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function. Here we have determined, for the first time, the structur
Externí odkaz:
https://doaj.org/article/778182bfccb74dee8f9cf0bf3a34a3b7
Autor:
Yongzhen Liu, Chao Qin, Youliang Rao, Chau Ngo, Joshua J. Feng, Jun Zhao, Shu Zhang, Ting-Yu Wang, Jessica Carriere, Ali Can Savas, Mehrnaz Zarinfar, Stephanie Rice, Hanging Yang, Weiming Yuan, Julio A. Camarero, Jianhua Yu, Xiaojiang S. Chen, Chao Zhang, Pinghui Feng
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral
Externí odkaz:
https://doaj.org/article/d1f591fa063b42b0b3faac6bdd373a47
Publikováno v:
Molecules, Vol 27, Iss 19, p 6430 (2022)
This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein–protein interactions remains challenging, as the interacting surfaces are rela
Externí odkaz:
https://doaj.org/article/34c3c76f25e14e01bb606e2f9364b9bb
Autor:
Enrico Tonelli, Alessandro Vitali, Julio J. Camarero, Michele Colangelo, Davide Frigo, Francesco Ripullone, Marco Carrer, Carlo Urbinati
Xylem anatomical traits in series of annual tree rings, allow establishing structure-function relationships and assessing species sensitivity to environmental variability. Extreme events such as late spring frosts (LSF) and drought spells are among t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa8bf60ad6c9101d012764d4f0d4fd5
https://doi.org/10.5194/egusphere-egu23-9237
https://doi.org/10.5194/egusphere-egu23-9237
Autor:
Dipankar Chaudhuri, Rajasekaran Ganesan, Alicia Vogelaar, Julio A. Camarero, Paul M. Beringer, Mansour A. Dughbaj
Publikováno v:
J Org Chem
Classical approaches for the backbone cyclization of polypeptides require conditions that may compromise the chirality of the C-terminal residue during the activation step of the cyclization reaction. Here, we describe an efficient epimerization-free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d900c3588110d8ab8ac49798a01ed6
https://doi.org/10.1021/acs.joc.1c01858
https://doi.org/10.1021/acs.joc.1c01858
Autor:
Joshua J Feng, Youliang Rao, Xiaojiang S Chen, Ali Can Savas, Hanging Yang, Pinghui Feng, Yongzhen Liu, Mehrnaz Zarinfar, Ting-Yu Wang, Chau Ngo, Chao Qin, Stephanie Rice, Shu Zhang, Weiming Yuan, Jun Zhao, Julio A. Camarero, Chao Zhang, Jianhua Yu, Jessica Carriere
Publikováno v:
mBio
mBio, Vol 12, Iss 5 (2021)
mBio, Vol 12, Iss 5 (2021)
Newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic with astonishing mortality and morbidity. The high replication and transmission of SARS-CoV-2 are remarkably distinct from those of previous closely r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7d146ba6a9f113735da6ac53cd8f1b
http://europepmc.org/articles/PMC8546575
http://europepmc.org/articles/PMC8546575
Publikováno v:
Biochemical Journal. 476:67-83
The use of disulfide-rich backbone-cyclized polypeptides, as molecular scaffolds to design a new generation of bioimaging tools and drugs that are potent and specific, and thus might have fewer side effects than traditional small-molecule drugs, is g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baf9782cfdd7692d84be36915c236cd
https://doi.org/10.1042/bcj20180792
https://doi.org/10.1042/bcj20180792
Autor:
Teshome Leta Aboye, Lisa Ramirez, Rajasekaran Ganesan, Julio A. Camarero, Paul M. Beringer, Steven Beringer, Mansour A. Dughbaj, Alexander Shekhtman
Publikováno v:
Chemistry
The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to the rapid development of drug resistance to current antibiotic therapeutics. Respiratory failure and septicemia are the leading causes of mortality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8e7ec2436b33da9a515de8663c9e68
https://pubmed.ncbi.nlm.nih.gov/34159664
https://pubmed.ncbi.nlm.nih.gov/34159664
Publikováno v:
Methods Mol Biol
Expressed Protein Ligation ISBN: 9781071604335
Expressed Protein Ligation ISBN: 9781071604335
Cyclotides are naturally occurring microproteins (≈30 residues long) present in several families of plants. All cyclotides share a unique head-to-tail circular knotted topology containing three disulfide bridges forming a cystine knot topology. Cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1cff19da12aa569abecdd1ac2a81c3
https://pubmed.ncbi.nlm.nih.gov/32144675
https://pubmed.ncbi.nlm.nih.gov/32144675
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:1212-1219
We report the high-yield heterologous expression of bioactive θ-defensin RTD-1 inside Escherichia coli cells by making use of intracellular protein trans-splicing in combination with a high efficient split-intein. RTD-1 is a small backbone-cyclized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8303ad6ee6b375a582280f6e65c0b6a1
https://doi.org/10.1016/j.bmc.2017.09.002
https://doi.org/10.1016/j.bmc.2017.09.002