Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Julijana Milojevic"'
Autor:
M. Monsur Ali, Michael G. Wolfe, Manali Mukherjee, Katherine Radford, Zil Patel, Dawn White, Julijana Milojevic, Alfredo Capretta, Parameswaran Nair, John D. Brennan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Eosinophils are granulocytes that play a significant role in the pathogenesis of asthma and other airway diseases. Directing patient treatment based on the level of eosinophilia has been shown to be extremely effective in reducing exacerbati
Externí odkaz:
https://doaj.org/article/1f71906723564805bc93196351e347f6
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1865:1529-1543
It is now established that understanding the molecular basis of biological function requires atomic resolution maps of both structure and dynamics. Here, we review several illustrative examples of functional dynamics selected from our work on cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15e5d436e6aca97f52150b777322f5b
https://doi.org/10.1016/j.bbapap.2017.09.005
https://doi.org/10.1016/j.bbapap.2017.09.005
Publikováno v:
Journal of Alzheimer's Disease. 17:281-294
Human HtrA2 is part of the HtrA family of ATP-independent serine proteases that are conserved in both prokaryotes and eukaryotes and localizes to the intermembrane space of the mitochondria. Several recent reports have suggested that HtrA2 is importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06012de81e678ddcbc6cbfce8287d72
https://doi.org/10.3233/jad-2009-1037
https://doi.org/10.3233/jad-2009-1037
Publikováno v:
Journal of the American Chemical Society. 129:4282-4290
Human serum albumin (HSA) inhibits the formation of amyloid beta-peptide (Abeta) fibrils in human plasma. However, currently it is not known how HSA affects the formation of the highly toxic soluble diffusible oligomers that occur in the initial stag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca50658e55dd3e9917386554a57e565b
https://doi.org/10.1021/ja067367+
https://doi.org/10.1021/ja067367+
Publikováno v:
The Journal of Physical Chemistry B. 110:20664-20670
The measurement of 1H off-resonance nonselective relaxation rates (R(theta,ns)) has been recently proposed as an effective method to probe peptide self-recognition, opening new perspectives in the understanding of the prefibrillization oligomerizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d6b751ef129c832505b1f4dfdfb4d1
https://doi.org/10.1021/jp063194z
https://doi.org/10.1021/jp063194z
Autor:
Ana Maria Ortiz, Giuseppe Melacini, Montserrat Costa, Juan Ignacio Jorquera, Julijana Milojevic
Publikováno v:
Journal of Alzheimer's disease : JAD. 38(4)
Background A promising approach for treating Alzheimer's disease relies on the net efflux of the amyloid-β (Aβ) peptide from the brain to peripheral plasma, as a result of plasma Aβ clearance promoted by plasma removal and therapeutic albumin repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3853bac499768cbab08fcf722fadf5c
https://pubmed.ncbi.nlm.nih.gov/24072068
https://pubmed.ncbi.nlm.nih.gov/24072068
Publikováno v:
Biophysical journal. 105(2)
The iron-transport glycoprotein transferrin has recently been shown to serve as a potent inhibitor of Aβ self-association. Although this novel, to our knowledge, inhibitory function of transferrin is of potential therapeutic interest for the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4669160b67ec990e54d22b9613013781
https://pubmed.ncbi.nlm.nih.gov/23870249
https://pubmed.ncbi.nlm.nih.gov/23870249
Publikováno v:
The journal of physical chemistry. B. 112(18)
Saturation transfer difference (STD) methods recently have been proposed to be a promising tool for self-recognition mapping at residue and atomic resolution in amyloidogenic peptides. Despite the significant potential of the STD approach for systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91f5a13ed05e967d3f63c1dbc46f803
https://pubmed.ncbi.nlm.nih.gov/18410162
https://pubmed.ncbi.nlm.nih.gov/18410162
Publikováno v:
Biophysical Journal. (9):2585-2594
Human serum albumin (HSA) is not only a fatty acid and drug carrier protein, it is also a potent inhibitor of Abeta self-association in plasma. However, the mechanism underlying the inhibition of Abeta fibrillization by HSA is still not fully underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd1f7b2a5843ceaa2cd84f7e68398a0
Publikováno v:
Biophysical Journal. (7):1700-1709
Human serum albumin (HSA) is a potent inhibitor of Aβ self-association and this novel, to our knowledge, function of HSA is of potential therapeutic interest for the treatment of Alzheimer’s disease. It is known that HSA interacts with Aβ oligome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f68e14be9db9c30038bded86d5df9c7