Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Juliette Molnos"'
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38149 (2012)
Brain microvascular endothelial cells (BEC) constitute the blood-brain barrier (BBB) which forms a dynamic interface between the blood and the central nervous system (CNS). This highly specialized interface restricts paracellular diffusion of fluids
Externí odkaz:
https://doaj.org/article/2a01e4953ad04c77be093beeb02a809d
Autor:
Krishna E. Tobón, Jim Rosinski, Paul Delmar, John F. Reidhaar-Olson, Mark DeMario, Tri Quang Nguyen, Steve R. Ritland, Ruediger Rueger, Patricia Mcloughlin, Wanda DePinto, Charu Kanwal, Holly Hilton, Windy Berkofsky-Fessler, Juliette Molnos
Publikováno v:
Molecular Cancer Therapeutics. 8:2517-2525
A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is a potent cyclin-dependent kinase inhibitor with a potent antiproliferative effect at pharmacologically relevant doses and
Autor:
Christian Wagner, Wolfgang Keck, Kurt Amrein, Juliette Molnos, Martin Stieger, Nicholas Flint, Markus Kamber, Patrick Caspers, Antoine de Saizieu, Roland Lange
Publikováno v:
Gene. 237:223-234
In bacteria, adaptive responses to environmental stimuli are often initiated by two-component signal transduction systems (TCS). The prototypical TCS comprises two proteins: a histidine kinase (HK, hk) and a response regulator (RR rr). Recent researc
Publikováno v:
Il Farmaco. 53:266-272
Csk is a cellular protein tyrosine kinase (PTK) that has been shown to specifically regulate the activity of Src kinase family members by phosphorylation of a carboxy-terminal tyrosine residue. The molecular mechanisms controlling Csk regulation and
A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD)
Publikováno v:
Analytical biochemistry. 319(1)
Bacterial malonyl-CoA:acyl carrier protein transacylase catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of acyl carrier protein. Malonyl-ACP, the product of this enzymatic reaction, is
Publikováno v:
Journal of microbiological methods. 42(2)
Insertional mutagenesis is a technique often used to inactivate genes in Streptococcus pneumoniae. Using conventional vectors, a 5' segment of the targeted gene remains under the control of the gene's authentic promoter following gene disruption. Thu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(4)
An Escherichia coli expression system overproducing the bacterial chaperones GroES and GroEL was engineered and has been successfully used to produce large quantities of the recombinant human protein-tyrosine kinase p50csk. The co-overproduction of t
Autor:
Willi Bannwarth, Hans-Werner Lahm, J. E. Scheffler, Juliette Molnos, Paul Burn, Nicholas Flint, Kurt Amrein, Baerbel Panholzer
Publikováno v:
Biochimica et biophysica acta. 1222(3)
The protein tyrosine kinase p56lck and other members of the src family can transduce signals from activated cell-surface receptors. As we showed earlier the GTPase-activating protein (GAP), a regulator of p21ras, is a substrate of p56lck. Here, trypt