Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus

Autor: Gabrielle Bourgeois, Juliette Létoquart, Nhan van Tran, Marc Graille

Publikováno v: Biomolecules, Vol 7, Iss 1, p 7 (2017)

Post-transcriptional and post-translational modifications are very important for the control and optimal efficiency of messenger RNA (mRNA) translation. Among these, methylation is the most widespread modification, as it is found in all domains of li

Externí odkaz: https://doaj.org/article/6c834670354347f4a4a2217ea5909dca

Structural insight into the formation of lipoprotein-β-barrel complexes

Autor: Antonio N. Calabrese, Gwennaelle Louis, Sheena E. Radford, Raquel Rodríguez-Alonso, Han Remaut, Bogdan I. Iorga, Juliette Létoquart, Van Son Nguyen, Seung-Hyun Cho, Jean-François Collet

Publikováno v: Nature Chemical Biology
Nature chemical biology
Nature Chemical Biology, Nature Publishing Group, 2020, 16, pp.1019-1025. ⟨10.1038/s41589-020-0575-0⟩
Nature chemical biology, Vol. 16, no. 9, p. 1019-1025 (2020)

International audience; The β-barrel assembly machinery (BAM) inserts outer membrane β-barrel proteins (OMPs) in the outer membrane of Gram-negative bacteria. In Enterobacteriacea, BAM also mediates export of the stress sensor lipoprotein RcsF to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5360c0b3f7f1b4ccf14bf38dce528c

Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification

Autor: Dominique Liger, W. Zhang, Tamara Basta, Herman van Tilbeurgh, Patrick Forterre, Juliette Létoquart, Inès Li de la Sierra-Gallay, A. Pichard-Kostuch, M.C. Daugeron, Bruno Collinet

Publikováno v: RNA
RNA, 2018, 24 (7), pp.926--938. ⟨10.1261/rna.066092.118⟩
RNA, Cold Spring Harbor Laboratory Press, 2018, 24 (7), pp.926--938. ⟨10.1261/rna.066092.118⟩

N6-threonyl-carbamoyl adenosine (t6A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t6A stabilizes the codon–anticodon interaction and hence promotes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee66c60104d2f3e1fa2590339d8904a
https://hal.science/hal-02183256/file/RNA-2018-Pichard-Kostuch-926-38.pdf

Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes

Autor: Nhan, van Tran, Leslie, Muller, Robert L, Ross, Roxane, Lestini, Juliette, Létoquart, Nathalie, Ulryck, Patrick A, Limbach, Valérie, de Crécy-Lagard, Sarah, Cianférani, Marc, Graille

Publikováno v: Nucleic acids research. 46(16)

Protein synthesis is a complex and highly coordinated process requiring many different protein factors as well as various types of nucleic acids. All translation machinery components require multiple maturation events to be functional. These include

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6deb253f4aaf216f719272ee5d89bd2
https://pubmed.ncbi.nlm.nih.gov/30010922

Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes

Autor: Gabrielle Bourgeois, Juliette Létoquart, Denis L. J. Lafontaine, Emmeline Huvelle, Marc Graille, Christiane Zorbas, Ludivine Wacheul, Valérie Heurgué-Hamard

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (51), pp.E5518-E5526. ⟨10.1073/pnas.1413089111⟩

The eukaryotic small ribosomal subunit carries only four ribosomal (r) RNA methylated bases, all close to important functional sites. N(7)-methylguanosine (m(7)G) introduced at position 1575 on 18S rRNA by Bud23-Trm112 is at a ridge forming a steric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fdef49ba7ae7dab433698ca82583a2
https://hal.archives-ouvertes.fr/hal-01107275