Výsledky vyhledávání - "Juliette Janson"

Akademický článek

Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats

Autor: Juliette Janson, Gudrun Andersson, Lars Bergquist, Maria Eriksson, Joost H.A. Folgering

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 22, Iss , Pp - (2020)

Mucopolysaccharidosis III A (MPS IIIA) is an autosomal recessive lysosomal storage disorder caused by deficiency of the enzyme sulfamidase. The disorder results in accumulation of heparan sulfate, lysosomal enlargement and cellular and organ dysfunct

Externí odkaz: https://doaj.org/article/9d2af5b0e9cc4632917c973c163332fd

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Akademický článek

Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice

Autor: Susanne Gustavsson, Elisabet Ohlin Sjöström, Agneta Tjernberg, Juliette Janson, Ulrica Westermark, Tommy Andersson, Åsa Makower, Erik Arnelöf, Gudrun Andersson, Jan Svartengren, Carina Ekholm, Stefan Svensson Gelius

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 21, Iss , Pp - (2019)

Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder (LSD) characterized by severe central nervous system (CNS) degeneration. The disease is caused by mutations in the SGSH gene coding for the lysosomal enzyme sulfamidase. Sulfa

Externí odkaz: https://doaj.org/article/5c5925a40eaf4e558c81d318fcb0dd0e

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Akademický článek

An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function.

Autor: Jenny U Johansson, Jesper Ericsson, Juliette Janson, Simret Beraki, Davor Stanić, Slavena A Mandic, Martin A Wikström, Tomas Hökfelt, Sven Ove Ogren, Björn Rozell, Per-Olof Berggren, Christina Bark

Publikováno v: PLoS Genetics, Vol 4, Iss 11, p e1000278 (2008)

Alternative splicing is an evolutionary innovation to create functionally diverse proteins from a limited number of genes. SNAP-25 plays a central role in neuroexocytosis by bridging synaptic vesicles to the plasma membrane during regulated exocytosi

Externí odkaz: https://doaj.org/article/2c86a0d4010148f5a31eb107bae68898

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Robust LC–MS/MS methods for analysis of heparan sulfate levels in CSF and brain for application in studies of MPS IIIA

Autor: Åsa Makower, Susanne Gustavsson, Agneta Tjernberg, Stefan Svensson Gelius, Tommy Andersson, Juliette Janson, Erik Arnelöf, Per-Olof Edlund

Publikováno v: Bioanalysis. 11:1389-1403

Aim: Accumulation of heparan sulfate (HS) is associated with the neurodegenerative disorder Mucopolysaccharidosis type IIIA (MPS IIIA). Here, we compare HS levels in brain and cerebrospinal fluid (CSF) of MPS IIIA mice after treatment with a chemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790915dc4edc60537bef2b2a22010228
https://doi.org/10.4155/bio-2019-0095

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Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats

Autor: Joost H.A. Folgering, Maria Eriksson, Lars Bergquist, Gudrun Andersson, Juliette Janson

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 22, Iss, Pp-(2020)
Molecular Genetics and Metabolism Reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5926859a8eba56927ab317fa4978ed
http://www.sciencedirect.com/science/article/pii/S221442691930196X

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AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

Autor: Karin Kaspersson, Juliette Janson, Johanna Fälting, Gvido Cebers, Samantha Budd Haeberlein, Fredrik Jeppsson, Susanna Eketjäll, Alan R. Kugler, Anna Bogstedt, Robert C. Alexander

Publikováno v: Journal of Alzheimer's Disease

A growing body of pathological, biomarker, genetic, and mechanistic data suggests that amyloid accumulation, as a result of changes in production, processing, and/or clearance of brain amyloid-β peptide (Aβ) concentrations, plays a key role in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65beb77a630968cc8f1f9d69367c2ef9
https://doi.org/10.3233/jad-150834

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Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department

Autor: Sanja Juric, Janet Hoogstraate, Tjerk Bueters, Margareta Bergh, Olle Gissberg, Yin Hu, Pawel Baranczewski, Jenny U. Johansson, Juliette Janson, Carrie Tsoi, Anna Breitholtz-Emanuelsson, Anders E. G. Lindgren, Sveinn Briem, Anna-Karin Sohlenius-Sternbeck, Johan Bylund

Publikováno v: Current Drug Metabolism. 17:253-270

Background: The disposition of a drug is dependent on interactions between the body and the drug, its molecular properties and the physical and biological barriers presented in the body. In order for a drug to have a desired pharmacological effect it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d040509b920ac9ebcf3db07401db1e
https://doi.org/10.2174/1389200217666151210125637

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Distribution of chemically modified rhSulfamidase to CNS monitored by brain microdialysis and repeated CSF sampling after intravenous administration in rat

Autor: Joost H.A. Folgering, Gudrun Andersson, Juliette Janson, Maria Eriksson, Lars Bergquist

Publikováno v: Molecular Genetics and Metabolism. 126:S79

Mucopolysaccharidosis type IIIA (MPS IIIA) is an autosomal recessive disorder caused by absence or deficiency of the lysosomal enzyme sulfamidase. Glycans of recombinant human sulfamidase were chemically modified to generate CM-rhSulfamidase with ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::742e6923e26d41046a95c800146bc3e4
https://doi.org/10.1016/j.ymgme.2018.12.193

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Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

Autor: Christin Andersson, Per Ola Freskgård, Matthew Burrell, Lutz Jermutus, Carl I. Webster, Juliette Janson, Anna Bogstedt, Simon J. Henderson, Ulrich Haupts, Rajesh Narwal, Tom Goldschmidt, Ann-Charlott Steffen, Jan Tebbe, Susan B. Fowler, Paulina Appelkvist

Publikováno v: Brain

Lowering levels of peripheral amyloid-β has been proposed as a strategy to reduce plaques in patients with Alzheimer’s disease. Henderson et al. test a modified version of the amyloid-degrading enzyme neprilysin in rats, monkeys and Tg2576 mice. L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94a9430aba27b96a125b51cbeba9616
http://europepmc.org/articles/PMC3914468

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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

Autor: Karin Kolmodin, Juliette Janson, Britt-Marie Swahn, Stefan von Berg, Tjerk Bueters, Gvido Cebers, Ann-Cathrine Radesäter, Johanna Fälting, Fredrik Jeppsson, Susanne Gustavsson, Bart Ploeger, Sofia Karlström, Susanna Eketjäll, Lise-Lotte Olsson

Publikováno v: Journal of Biological Chemistry. 287:41245-41257

β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid precursor protein (APP) and formation of amyloid β peptide (Aβ) species. Because cerebral deposition of Aβ species might

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be78180b718cc33322fedb5df5eba93
https://doi.org/10.1074/jbc.m112.409110

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