Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Juliette Fremaux"'
Autor:
Juliette Fremaux, Claire Venin, Laura Mauran, Robert H. Zimmer, Gilles Guichard, Sébastien R. Goudreau
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The peptide hormone GLP-1 has the potential to be a remedy for diabetes type II, yet is unstable. Here, the authors synthesized α-peptide-oligourea hybrid analogues of GLP-1 some of which showing significantly prolonged activity in vivo.
Externí odkaz:
https://doaj.org/article/7e2c09e5f5e9452e9f698d011ed0817b
Autor:
Maxime Neuville, Sébastien R. Goudreau, Juliette Fremaux, Laura Mauran-Ambrosino, Sébastien Fribourg, Anna Y. Belorusova, Christel Dolain, Judit Osz, Natacha Rochel, Gilles Guichard, Léonie Cussol, Jérémie Buratto
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, ⟨10.1002/anie.202008992⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, ⟨10.1002/anie.202008992⟩
Efficient optimization of a peptide lead into a drug candidate frequently needs further transformation to augment properties such as bioavailability. Among the different options, foldamers, which are sequence-based oligomers with precise folded confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cadec756596d26e4291809b6b810b3a
http://hdl.handle.net/20.500.12278/106475
http://hdl.handle.net/20.500.12278/106475
Publikováno v:
France, Patent n° : US20200155637A1. 2020
(EN) The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7c061ac100dcc92aed3a0137922053ad
https://hal.science/hal-03460987
https://hal.science/hal-03460987
Autor:
Claire Venin, Robert H. Zimmer, Ben Jones, Laura Mauran, Stavroula Bitsi, Alejandra Tomas, Didier Rognan, Florian Koensgen, Gilles Guichard, Sébastien R. Goudreau, Maria Lucey, Juliette Fremaux
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2019, 10 (42), pp.9872-9879. ⟨10.1039/c9sc02079a⟩
Chemical Science, The Royal Society of Chemistry, 2019, 10 (42), pp.9872-9879. ⟨10.1039/C9SC02079A⟩
Chemical Science, The Royal Society of Chemistry, 2019, 10 (42), pp.9872-9879. ⟨10.1039/c9sc02079a⟩
Chemical Science, The Royal Society of Chemistry, 2019, 10 (42), pp.9872-9879. ⟨10.1039/C9SC02079A⟩
International audience; The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of alpha-amino acid residues with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa0810e201c5d94816890ca7af7126b
http://hdl.handle.net/20.500.12278/7639
http://hdl.handle.net/20.500.12278/7639
Autor:
Gilles Guichard, Caterina Lombardo, Cameron D. Mackereth, Frédéric Rosu, Olivier Lambert, Laura Mauran, Juliette Fremaux, Marion Decossas, Valérie Gabelica, Gavin W. Collie, Karolina Pulka-Ziach
Publikováno v:
Nature Chemistry. 7:871-878
The design and construction of biomimetic self-assembling systems is a challenging yet potentially highly rewarding endeavour that contributes to the development of new biomaterials, catalysts, drug-delivery systems and tools for the manipulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ea207acc1da0260cafe1f5f73139cf
https://doi.org/10.1038/nchem.2353
https://doi.org/10.1038/nchem.2353
Autor:
Gilles Guichard, Brice Kauffmann, Benoit Odaert, Laura Mauran, Juliette Fremaux, Karolina Pulka-Ziach
Publikováno v:
Angewandte Chemie (International ed. in English). 54(34)
Short α-peptides with less than 10 residues generally display a low propensity to nucleate stable helical conformations. While various strategies to stabilize peptide helices have been previously reported, the ability of non-peptide helical foldamer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcc2452c12440ec4a2ecfc0d77573c8
https://pubmed.ncbi.nlm.nih.gov/26136402
https://pubmed.ncbi.nlm.nih.gov/26136402
Autor:
Romina Wechsel, Julien Maury, Juliette Fremaux, Scott P. France, Gilles Guichard, Jonathan Clayden
Publikováno v:
Chemical communications (Cambridge, England). 50(95)
The ability of urea-linked oligomers of achiral diamines (achiral analogues of the well-established chiral oligourea foldamers) to adopt helical conformations was explored spectroscopically. Up to four achiral units were ligated either to a well-form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f371dda187f4dbbf5f530b9774390f8e
https://pubmed.ncbi.nlm.nih.gov/25327885
https://pubmed.ncbi.nlm.nih.gov/25327885
Publikováno v:
The Journal of organic chemistry. 79(12)
The synthesis and conformational analysis of aliphatic oligoureas containing multiple adjacent N-alkylated units derived from proline (i.e., Pro(u)) are reported. The insertion of trisubstituted ureas in the main chain of N,N'-linked oligourea foldam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f5d2bfd51aff44ff8b9e37e4c58af5
https://pubmed.ncbi.nlm.nih.gov/24810879
https://pubmed.ncbi.nlm.nih.gov/24810879
Publikováno v:
Chemical communications (Cambridge, England). 49(67)
The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9285fd211030c26d761dad0786c4ce3
https://pubmed.ncbi.nlm.nih.gov/23862177
https://pubmed.ncbi.nlm.nih.gov/23862177