In vivo chromatic and spatial tuning of foveolar retinal ganglion cells in Macaca fascicularis.

Autor: Tyler Godat, Nicolas P Cottaris, Sara Patterson, Kendall Kohout, Keith Parkins, Qiang Yang, Jennifer M Strazzeri, Juliette E McGregor, David H Brainard, William H Merigan, David R Williams

Publikováno v: PLoS ONE, Vol 17, Iss 11, p e0278261 (2022)

The primate fovea is specialized for high acuity chromatic vision, with the highest density of cone photoreceptors and a disproportionately large representation in visual cortex. The unique visual properties conferred by the fovea are conveyed to the

Externí odkaz: https://doaj.org/article/147f6bed29484ff985eccf7d5a12e602

Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution

Autor: David M. Gamm, Lindsey D. Jager, Kamal Dhakal, Sara Stuedemann, Juliette E. McGregor, David A. DiLoreto, David R. Williams, Brittany Bateman, M. Joseph Phillips, Allison L. Ludwig, William H. Merigan, Ebrahim Aboualizadeh, Jennifer M. Strazzeri, Jennifer J. Hunter, Kelsy L. Nilles

Publikováno v: Stem Cell Reports

Summary Stem cell-based transplantation therapies offer hope for currently untreatable retinal degenerations; however, preclinical progress has been largely confined to rodent models. Here, we describe an experimental platform for accelerating photor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c1db8ef5ce762316be98228de1087b
http://europepmc.org/articles/PMC7419740

Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation

Autor: Teresa Puthussery, Colin J Chu, David R. Williams, Peter J. Murphy, William H. Merigan, Tyler Godat, William S. Fischer, Zhengyang Xu, Brittany Bateman, Juliette E. McGregor, Karteek Kunala, Jennifer M. Strazzeri, Keith Parkins

Publikováno v: McGregor, J E, Kunala, K, Xu, Z, Murphy, P J, Godat, T, Strazzeri, J M, Bateman, B A, Fischer, W S, Parkins, K, Chu, C J, Puthussery, T, Williams, D R & Merigan, W H 2021, ' Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation ', Molecular Therapy . https://doi.org/10.1016/j.ymthe.2021.09.014

All retina-based vision restoration approaches rely on the assumption that photoreceptor loss does not preclude reactivation of the remaining retinal architecture. Whether extended periods of vision loss limit the efficacy of restorative therapies at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4e16318cda80a4f91042948e378052
https://pubmed.ncbi.nlm.nih.gov/34547460

Optogenetic restoration of retinal ganglion cell activity in the living primate

Autor: Kamal Dhakal, William H. Merigan, Tyler Godat, Juliette E. McGregor, Keith Parkins, Jennifer M. Strazzeri, Brittany Bateman, David R. Williams, William S. Fischer

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications

Optogenetic therapies for vision restoration aim to confer intrinsic light sensitivity to retinal ganglion cells when photoreceptors have degenerated and light sensitivity has been irreversibly lost. We combine adaptive optics ophthalmoscopy with cal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96deb6a30572f45b57b6cb42c13e0f38
https://doi.org/10.1038/s41467-020-15317-6

Functional Assessment of Vision Restoration

Autor: Juliette E, McGregor, David R, Williams, William H, Merigan

Publikováno v: Advances in experimental medicine and biology. 1185

Despite the many promising therapeutic approaches identified in the laboratory, it has proven extremely challenging to translate basic science advances into the eye clinic. There are many recent examples of clinical trials (e.g., Holz FG, Sadda SR, B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac824ad55c46f29ed914aee389edbd8c
https://pubmed.ncbi.nlm.nih.gov/31884603