Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases

Autor: Lila Carniglia, Delia Ramírez, Daniela Durand, Julieta Saba, Juan Turati, Carla Caruso, Teresa N. Scimonelli, Mercedes Lasaga

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

Microglial cells are responsible for immune surveillance within the CNS. They respond to noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory response. This is followed by release of anti-inflammatory mediators a

Externí odkaz: https://doaj.org/article/2f9fa278694c457a918be1b90d40fc3a

A metabotropic glutamate receptor 3 ( mGlu3R ) isoform playing neurodegenerative roles in astrocytes is prematurely up‐regulated in an Alzheimerʼs model

Autor: Juan Turati, Julieta Rudi, Juan Beauquis, Lila Carniglia, Federico López Couselo, Julieta Saba, Carla Caruso, Flavia Saravia, Mercedes Lasaga, Daniela Durand

Publikováno v: Journal of Neurochemistry. 161:366-382

Subtype 3 metabotropic glutamate receptor (mGlu3R) displays a broad range of neuroprotective effects. We previously demonstrated that mGlu3R activation in astrocytes protects hippocampal neurons from Aβ neurotoxicity through stimulation of both neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e16287f5e203f1dde60329100bb5d6
https://doi.org/10.1111/jnc.15610

Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin

Autor: Federico López Couselo, Andrea De Laurentiis, Julieta Saba, Mercedes Lasaga, Juan Turati, Lila Carniglia, Daniela Elizabeth Durand, Carla Mariana Caruso

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cultured rat astrocytes treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3046909a6b4dfeed1631fcf69f872123
https://pubmed.ncbi.nlm.nih.gov/33023623

Unraveling the β-AMYLOID clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPα, and class-A scavenger receptor

Autor: Julieta Saba, Mercedes Lasaga, Daniela Elizabeth Durand, Rommy von Bernhardi, Carla Mariana Caruso, Delia Ramírez, Juan Turati, Lila Carniglia, María Julieta Rudi

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The mechanics of β-amyloid (Aβ) clearance by astrocytes has not been univocally described, with different mediators appearing to contribute to this process under different conditions. Our laboratory has demonstrated neuroprotective effects of astro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bd7b65588abe626a3846024511ef22
https://www.sciencedirect.com/science/article/abs/pii/S0197018619304656

Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection

Autor: Carla Mariana Caruso, Juan Turati, Mercedes Lasaga, Julieta Saba, Delia Ramírez, Lila Carniglia, Daniela Elizabeth Durand

Astrocytes are glial cells that help maintain brain homeostasis and become reactive in neurodegenerative processes releasing both harmful and beneficial factors. We have demonstrated that brain-derived neurotrophic factor (BDNF) expression is induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea789024cac38789e3725d5be82932a4
Wiley Online Library