Výsledky vyhledávání - "Juliet L Emery"

Akademický článek

Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production.

Autor: Ariana Barbera Betancourt, Juliet L Emery, Asha Recino, F Susan Wong, Anne Cooke, Klaus Okkenhaug, Maja Wallberg

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0146516 (2016)

Type 1 diabetes is caused by the destruction of insulin producing beta cells by the immune system. The p110δ isoform of PI3K is expressed primarily in cells of haematopoietic origin and the catalytic activity of p110δ is important for the activatio

Externí odkaz: https://doaj.org/article/7b36e4f4e47e4e7ea1556bc362fd401d

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Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production

Autor: Anne Cooke, Ariana Barbera Betancourt, Klaus Okkenhaug, Juliet L. Emery, Maja Wallberg, Asha Recino, F. Susan Wong

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0146516 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ea22c76e9de01919ef98203feb3882
https://www.repository.cam.ac.uk/handle/1810/253733

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Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells

Autor: Klaus Okkenhaug, Tea Gogishvili, Fernando Elias, Kevin M. Dennehy, Thomas Hünig, Juliet L. Emery, Kirsty McPherson

Publikováno v: European Journal of Immunology. 38:2528-2533

Almost all responses of naive T cells require co-stimulation, i.e. engagement of the clonotypic TCR with relevant antigen/MHC and the co-stimulatory molecule CD28. How CD28 contributes to T-cell proliferation remains poorly understood, with widely co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f811993a1b6a085522609e2379fa39
https://doi.org/10.1002/eji.200838223

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Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells

Autor: Juliet L. Emery, Klaus Okkenhaug, Thomas Rückle, Christian Rommel, Antonio Bilancio, Montserrat Camps, Bart Vanhaesebroeck

Publikováno v: Blood. 107:642-650

Mouse gene-targeting studies have documented a central role of the p110delta isoform of phosphoinositide 3-kinase (PI3K) in B-cell development and function. A defect in B-cell antigen receptor (BCR) signaling is key to this B-cell phenotype. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af17abbad6b2d0cc1cbafee16b7dc3f
https://doi.org/10.1182/blood-2005-07-3041

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Phosphoinositide 3-kinase in T cell activation and survival

Autor: Bart Vanhaesebroeck, Klaus Okkenhaug, Antonio Bilancio, Juliet L. Emery

Publikováno v: Biochemical Society Transactions. 32:332-335

PI3Ks (phosphoinositide 3-kinases) regulate diverse signalling pathways involved in growth, proliferation, survival, differentiation and metabolism. In T cells, PI3Ks can be activated by a number of different receptors, including the TcR (T cell rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8c5a4b86b99029a133ef0a2e6b0420
https://doi.org/10.1042/bst0320332

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The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development

Autor: Klaus Okkenhaug, Faruk Ramadani, Juliet L. Emery, Anne E. Corcoran, Fabien Garçon, Bart Vanhaesebroeck, Daniel J. Bolland

Publikováno v: Science Signaling. 3

B cell development is controlled by a series of checkpoints that ensure that the immunoglobulin (Ig)-encoding genes produce a functional B cell receptor (BCR) and antibodies. As part of this process, recombination-activating gene (Rag) proteins regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f69dc71e4d689cdbbe3653584bafa5
https://doi.org/10.1126/scisignal.2001104

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MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

Autor: Klaus Okkenhaug, Rose Zamoyska, Robert J. Salmond, Juliet L. Emery

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 183(11)

Ribosomal protein S6 (rpS6) is a key component of the translational machinery in eukaryotic cells and is essential for ribosome biogenesis. rpS6 is phosphorylated on evolutionarily conserved serine residues, and data indicate that rpS6 phosphorylatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b7febf8c3da2106f920a217ed47bb5
https://pubmed.ncbi.nlm.nih.gov/19917692

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CD28 provides T cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer

Autor: Klaus Okkenhaug, Robert Rottapel, Fabien Garçon, Emilio Hirsch, Takehiko Sasaki, Juliet L. Emery, Daniel T. Patton

Activation of PI3K is among the earliest signaling events observed in T cells after conjugate formation with antigen-presenting cells (APCs). The relevant PI3K catalytic isoform and relative contribution of the TcR and CD28 to PI3K activity at the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68146024760e10307f0bb84e1790177
http://hdl.handle.net/2318/34316

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