Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Juliet D French"'
Autor:
Lu Wang, Mainá Bitar, Xue Lu, Sebastien Jacquelin, Sneha Nair, Haran Sivakumaran, Kristine M. Hillman, Susanne Kaufmann, Rebekah Ziegman, Francesco Casciello, Harsha Gowda, Joseph Rosenbluh, Stacey L. Edwards, Juliet D. French
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background Long noncoding RNAs (lncRNAs) have surpassed the number of protein-coding genes, yet the majority have no known function. We previously discovered 844 lncRNAs that were genetically linked to breast cancer through genome-wide assoc
Externí odkaz:
https://doaj.org/article/a83c569fc00d4544a84739b1f231c21e
Autor:
Chanel E Smart, Marjan E Askarian Amiri, Ania Wronski, Marcel E Dinger, Joanna Crawford, Dmitry A Ovchinnikov, Ana Cristina Vargas, Lynne Reid, Peter T Simpson, Sarah Song, Christiane Wiesner, Juliet D French, Richa K Dave, Leonard da Silva, Amy Purdon, Megan Andrew, John S Mattick, Sunil R Lakhani, Melissa A Brown, Stuart Kellie
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40742 (2012)
The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis.
Externí odkaz:
https://doaj.org/article/d5eaa5f72a81446caa82d85295dc8909
Autor:
Natasha K. Tuano, Jonathan Beesley, Murray Manning, Wei Shi, Laura Perlaza-Jimenez, Luis F. Malaver-Ortega, Jacob M. Paynter, Debra Black, Andrew Civitarese, Karen McCue, Aaron Hatzipantelis, Kristine Hillman, Susanne Kaufmann, Haran Sivakumaran, Jose M. Polo, Roger R. Reddel, Vimla Band, Juliet D. French, Stacey L. Edwards, David R. Powell, Georgia Chenevix-Trench, Joseph Rosenbluh
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate cancer risk by regulating gene expressio
Externí odkaz:
https://doaj.org/article/6fa5b74012424fbe8ef3072e8a09b991
Autor:
Skye R. MacGregor, Donald P. McManus, Haran Sivakumaran, Thomas G. Egwang, Moses Adriko, Pengfei Cai, Catherine A. Gordon, Mary G. Duke, Juliet D. French, Natasha Collinson, Remigio M. Olveda, Gunter Hartel, Carlos Graeff-Teixeira, Malcolm K. Jones, Hong You
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104730- (2023)
Summary: Background: Schistosomiasis is a disease that significantly impacts human health in the developing world. Effective diagnostics are urgently needed for improved control of this disease. CRISPR-based technology has rapidly accelerated the dev
Externí odkaz:
https://doaj.org/article/27241a5a969d41faa0f509f7a55c7f7d
Autor:
Xiaofeng Du, Donald P. McManus, Juliet D. French, Natasha Collinson, Haran Sivakumaran, Skye R. MacGregor, Conor E. Fogarty, Malcolm K. Jones, Hong You
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Employing the flatworm parasite Schistosoma mansoni as a model, we report the first application of CRISPR interference (CRISPRi) in parasitic helminths for loss-of-function studies targeting the SmfgfrA gene which encodes the stem cell marker, fibrob
Externí odkaz:
https://doaj.org/article/1b457daa571b4084b6414d18c5bffc2a
Autor:
Mahdi Moradi Marjaneh, Jonathan Beesley, Tracy A. O’Mara, Pamela Mukhopadhyay, Lambros T. Koufariotis, Stephen Kazakoff, Nehal Hussein, Laura Fachal, Nenad Bartonicek, Kristine M. Hillman, Susanne Kaufmann, Haran Sivakumaran, Chanel E. Smart, Amy E. McCart Reed, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Daniel R. Barnes, Antonis C. Antoniou, Marcel E. Dinger, Nicola Waddell, Douglas F. Easton, Alison M. Dunning, Georgia Chenevix-Trench, Stacey L. Edwards, Juliet D. French
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements such as enhancers and promoters. However, the contribution of non-codi
Externí odkaz:
https://doaj.org/article/5403ef83152d415999f1d71d1048ca89
Autor:
Jonathan Beesley, Haran Sivakumaran, Mahdi Moradi Marjaneh, Luize G. Lima, Kristine M. Hillman, Susanne Kaufmann, Natasha Tuano, Nehal Hussein, Sunyoung Ham, Pamela Mukhopadhyay, Stephen Kazakoff, Jason S. Lee, Kyriaki Michailidou, Daniel R. Barnes, Antonis C. Antoniou, Laura Fachal, Alison M. Dunning, Douglas F. Easton, Nicola Waddell, Joseph Rosenbluh, Andreas Möller, Georgia Chenevix-Trench, Juliet D. French, Stacey L. Edwards
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these signals frequently fall in distal regulatory DNA elements that control gen
Externí odkaz:
https://doaj.org/article/fa6386535d1c4c20b6e802d061bc1526
Autor:
Mainá Bitar, Isela Sarahi Rivera, Isabela Almeida, Wei Shi, Kaltin Ferguson, Jonathan Beesley, Sunil R Lakhani, Stacey L Edwards, Juliet D French
Publikováno v:
Nucleic Acids Research.
Single-cell RNAseq has allowed unprecedented insight into gene expression across different cell populations in normal tissue and disease states. However, almost all studies rely on annotated gene sets to capture gene expression levels and sequencing
Autor:
Skye R. MacGregor, Donald P. McManus, Haran Sivakumaran, Juliet D. French, Catherine A. Gordon, Pengfei Cai, Remigio M. Olveda, Malcolm K. Jones, Hong You
Schistosomiasis is a disease that significantly impacts public health in the developing world. Effective diagnostics are urgently needed for improved control of this disease, but current diagnostic procedures lack the requisite sensitivity, portabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9acfb23882d5e4bff98872349d590ad
https://doi.org/10.1101/2022.11.11.22282198
https://doi.org/10.1101/2022.11.11.22282198
Autor:
Stacey L. Edwards, Juliet D. French
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 15:1-7
Breast cancer is the most common malignancy among women. Approximately 25% of hereditary breast cancer cases can explained by rare pathogenic variants in a small number of moderate- to high-penetrance predisposition genes, and at least another 20% by