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pro vyhledávání: '"Juliet A. Jones"'
Publikováno v:
Chemical Research in Toxicology. 16:1306-1317
A proteome profiling approach was used to compare effects of two toxicants, 1,1-dicloroethylene (DCE) and diclofenac, which covalently adduct hepatic proteins. Bile was examined as a potential source of protein alterations since both toxicants target
Publikováno v:
Analytical Chemistry. 73:1676-1683
A pattern recognition algorithm called SALSA (scoring algorithm for spectral analysis) has been developed to rapidly screen large numbers of peptide MS-MS spectra for fragmentation characteristics indicative of specific peptide modifications. The alg
Publikováno v:
Analytica Chimica Acta. 344:55-64
Dissolved oxygen can be reduced on platinum and gold electrodes, although the presence of adsorbing species can attenuate the amount of cathodic current observed. By monitoring the degree that the current is suppressed, one can indirectly monitor the
Publikováno v:
Advances in protein chemistry. 65
Publisher Summary The chapter focuses on the application of liquid chromatography (LC) tandem mass spectrometry (MS) (LC-MS-MS)-based approaches to identifying protein targets of modifications and mapping the modifications at the level of amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4732c221b2eb1bf739e4d9423110131f
https://doi.org/10.1016/s0065-3233(03)01020-9
https://doi.org/10.1016/s0065-3233(03)01020-9
Autor:
Daniel C. Liebler, Juliet A. Jones
Publikováno v:
Chemical research in toxicology. 13(12)
Dichloroethylene (DCE) is a hepatotoxin that undergoes cytochrome P450-catalyzed bioactivation in hepatocytes to form 2-chloroacetyl chloride and 1,1-dichloroethylene oxide. 2-Chloroacetyl chloride reacts with nucleophilic residues and with N-termina