Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Juliet, Forman"'
Autor:
Zachary T. Weber, Katharine A. Collier, David Tallman, Juliet Forman, Sachet Shukla, Sarah Asad, Justin Rhoades, Samuel Freeman, Heather A. Parsons, Nicole O. Williams, Romualdo Barroso-Sousa, Elizabeth H. Stover, Haider Mahdi, Carrie Cibulskis, Niall J. Lennon, Gavin Ha, Viktor A. Adalsteinsson, Sara M. Tolaney, Daniel G. Stover
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background Circulating tumor DNA (ctDNA) offers minimally invasive means to repeatedly interrogate tumor genomes, providing opportunities to monitor clonal dynamics induced by metastasis and therapeutic selective pressures. In metastatic can
Externí odkaz:
https://doaj.org/article/c88b661c2dd14e5595a5247ba01a0bfe
Autor:
Ziad Bakouny, David A. Braun, Sachet A. Shukla, Wenting Pan, Xin Gao, Yue Hou, Abdallah Flaifel, Stephen Tang, Alice Bosma-Moody, Meng Xiao He, Natalie Vokes, Jackson Nyman, Wanling Xie, Amin H. Nassar, Sarah Abou Alaiwi, Ronan Flippot, Gabrielle Bouchard, John A. Steinharter, Pier Vitale Nuzzo, Miriam Ficial, Miriam Sant’Angelo, Juliet Forman, Jacob E. Berchuck, Shaan Dudani, Kevin Bi, Jihye Park, Sabrina Camp, Maura Sticco-Ivins, Laure Hirsch, Sylvan C. Baca, Megan Wind-Rotolo, Petra Ross-Macdonald, Maxine Sun, Gwo-Shu Mary Lee, Steven L. Chang, Xiao X. Wei, Bradley A. McGregor, Lauren C. Harshman, Giannicola Genovese, Leigh Ellis, Mark Pomerantz, Michelle S. Hirsch, Matthew L. Freedman, Michael B. Atkins, Catherine J. Wu, Thai H. Ho, W. Marston Linehan, David F. McDermott, Daniel Y. C. Heng, Srinivas R. Viswanathan, Sabina Signoretti, Eliezer M. Van Allen, Toni K. Choueiri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Sarcomatoid and rhabdoid tumours are highly aggressive forms of renal cell carcinoma that are also responsive to immunotherapy. In this study, the authors perform a comprehensive molecular characterization of these tumours discovering an enrichment o
Externí odkaz:
https://doaj.org/article/65b689f6ed0042b1ab0807dd0eb2f0de
Autor:
Eliot C. Bush, Anne E. Clark, Carissa A. DeRanek, Alexander Eng, Juliet Forman, Kevin Heath, Alexander B. Lee, Daniel M. Stoebel, Zunyan Wang, Matthew Wilber, Helen Wu
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Genomic islands play an important role in microbial genome evolution, providing a mechanism for strains to adapt to new ecological conditions. A variety of computational methods, both genome-composition based and comparative, have
Externí odkaz:
https://doaj.org/article/4df4d9d46ad8439db721f4e2497715df
Autor:
Tomasz Kula, Gavin MacBeath, Genevieve M. Boland, Wandi Zhang, Donna Neuberg, Phuong M. Le, Giacomo Oliveira, Catherine J. Wu, Steven A. Carr, Qikai Xu, Patrick A. Ott, Moshe Sade-Feldman, Sachet A. Shukla, Nir Hacohen, Susan Klaeger, Juliet Forman, Dennie T. Frederick, Karl R. Clauser, Edward F. Fritsch, Nicoletta Cieri, Shuqiang Li, Derin B. Keskin, Kenneth J. Livak, Kari Stromhaug, Teddy Huang, Sune Justesen
Publikováno v:
Nature. 596:119-125
Interactions between T cell receptors (TCRs) and their cognate tumour antigens are central to antitumour immune responses1–3; however, the relationship between phenotypic characteristics and TCR properties is not well elucidated. Here we show, by l
Autor:
Samuel S. Freeman, Heather A. Parsons, Daniel G. Stover, Zachary Weber, Elizabeth H. Stover, Sarah Asad, Viktor A. Adalsteinsson, Gavin Ha, Sara M. Tolaney, David Tallman, Sachet A. Shukla, Justin Rhoades, Katharine Collier, Romualdo Barroso-Sousa, Juliet Forman, Haider Mahdi, Carrie Cibulskis, Nicole Williams, Niall J. Lennon
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Genome Medicine
Genome Medicine
BackgroundCirculating tumor DNA (ctDNA) offers minimally invasive means to repeatedly interrogate tumor genomes, providing opportunities to monitor clonal dynamics induced by metastasis and therapeutic selective pressures. In metastatic cancers, ctDN
Autor:
Romualdo Barroso-Sousa, Juliet Forman, Katharine Collier, Zachary T. Weber, Tejas R. Jammihal, Katrina Z. Kao, Edward T. Richardson, Tanya Keenan, Ofir Cohen, Michael P. Manos, Ryan C. Brennick, Patrick A. Ott, F. Stephen Hodi, Deborah A. Dillon, Victoria Attaya, Tess O'Meara, Nancy U. Lin, Eliezer M. Van Allen, Scott Rodig, Eric P. Winer, Elizabeth A. Mittendorf, Catherine J. Wu, Nikhil Wagle, Daniel G. Stover, Sachet A. Shukla, Sara M. Tolaney
Publikováno v:
JCO Precis Oncol
PURPOSE In metastatic triple-negative breast cancer (mTNBC), consistent biomarkers of immune checkpoint inhibitor (ICI) therapy benefit remain elusive. We evaluated the immune, genomic, and transcriptomic landscape of mTNBC in patients treated with I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fa82e75f5dc38813689b7ca3c1bdb4
https://europepmc.org/articles/PMC9848556/
https://europepmc.org/articles/PMC9848556/
Autor:
Zachary Weber, Ryan C. Brennick, Catherine J. Wu, F. Steve Hodi, Michael Manos, Romualdo Barroso-Sousa, Katherine A Collier, Deborah A. Dillon, Patrick A. Ott, Katrina Z. Kao, Sara M. Tolaney, Nikhil Wagle, Tanya Keenan, Scott J. Rodig, Elizabeth A. Mittendorf, Daniel G. Stover, Eliezer E. Van Allen, Nan Lin, Ofir Cohen, Sachet A. Shukla, Eric P. Winer, Juliet Forman, Edward T. Richardson
Publikováno v:
Cancer Research. 81:PS4-25
Background: Genomic mechanisms associated with response to ICI in mTNBC are largely unknown. The aim of this work is to assess the genomic and immune profiles of mTNBC samples collected from patients (pts) treated with ICI. Methods: We identified 31
Autor:
Miriam Ficial, Megan Wind-Rotolo, Opeyemi Jegede, Sachet A. Shukla, Liudmilla Elagina, Arlene H. Sharpe, Jean-Christophe Pignon, Miriam Sant’ Angelo, Andrew D. Cherniack, Lee Lichtenstein, Maxine Sun, John A. Steinharter, Donna Neuberg, Gordon J. Freeman, Ziad Bakouny, Juliet Forman, Yue Hou, Catherine J. Wu, David F. McDermott, Sabina Signoretti, Ashton C. Berger, Petra Ross-Macdonald, David A. Braun, Toni K. Choueiri, Paul J. Catalano, Eliezer M. Van Allen
Publikováno v:
Nat Med
PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced ccRCC enroll
Autor:
Pilar Baldominos, Alex Barbera-Mourelle, Olga Barreiro, Yu Huang, Andrew Wight, Jae-Won Cho, Xi Zhao, Guillem Estivill, Isam Adam, Xavier Sanchez, Shannon McCarthy, Julien Schaller, Zara Khan, Albert Ruzo, Ricardo Pastorello, Edward T. Richardson, Deborah Dillon, Paula Montero-Llopis, Romualdo Barroso-Sousa, Juliet Forman, Sachet A. Shukla, Sara M. Tolaney, Elizabeth A. Mittendorf, Ulrich H. von Andrian, Kai W. Wucherpfennig, Martin Hemberg, Judith Agudo
Publikováno v:
Cell. 185(10)
Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but patients relapse, highlighting the need to understand the mechanisms of resistance. We discovered that in primary breast cancer, tumor cells that resist T cell attac
Autor:
Xin Gao, Maxine Sun, Sabina Signoretti, Michael B. Atkins, Catherine J. Wu, Shaan Dudani, Thai H. Ho, Michelle S. Hirsch, Bradley Alexander McGregor, Ziad Bakouny, John A. Steinharter, Daniel Y.C. Heng, Miriam Sant'Angelo, Sylvan C. Baca, Eliezer M. Van Allen, David A. Braun, Lauren C. Harshman, Stephen Tang, Alice Bosma-Moody, Ronan Flippot, Pier Vitale Nuzzo, Kevin Bi, Amin Nassar, Yue Hou, Sarah Abou Alaiwi, Mark Pomerantz, Natalie I. Vokes, W. Marston Linehan, Megan Wind-Rotolo, Laure Hirsch, Giannicola Genovese, David F. McDermott, Jackson Nyman, Juliet Forman, Wanling Xie, Toni K. Choueiri, Jacob E. Berchuck, Jihye Park, Wenting Pan, Sabrina Y. Camp, Meng Xiao He, Gabrielle Bouchard, Xiao X. Wei, Matthew L. Freedman, Gwo-Shu Mary Lee, Petra Ross-Macdonald, Maura Sticco-Ivins, Sachet A. Shukla, Steven L. Chang, Leigh Ellis, Abdallah Flaifel, Srinivas R. Viswanathan, Miriam Ficial
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Sarcomatoid and rhabdoid (S/R) renal cell carcinoma (RCC) are highly aggressive tumors with limited molecular and clinical characterization. Emerging evidence suggests immune checkpoint inhibitors (ICI) are particularly effective for these tumors, al