Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration

Autor: Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan, Nathalie Janel

Publikováno v: Frontiers in Neurology, Vol 10 (2019)

Aging is one of the strongest risk factor for Alzheimer's disease (AD). However, several data suggest that dyslipidemia can either contribute or serve as co-factors in AD appearance. AD could be examined as a metabolic disorder mediated by peripheral

Externí odkaz: https://doaj.org/article/87c5adff996a4996a96a383afd040f80

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets

Autor: Hervé Le Stunff, Kelly Meneyrol, Nadim Kassis, Mark Ibberson, Julien Véret, Christophe Magnan, Lara Bellini, Isabelle Hainault, Jessica Denom, Céline Cruciani-Guglielmacci, Véronique Lenoir, Piero Marchetti, Agnieszka Blachnio-Zabielska, Mélanie Campana, Marta Chacinska, Carina Prip-Buus, Marco Bugliani, Bernard Thorens, Claude Rouch

Publikováno v: Diabetologia
Diabetologia, Springer Verlag, 2018, 61 (8), pp.1780-1793. ⟨10.1007/s00125-018-4629-8⟩

Dietary n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are known to influence glucose homeostasis. We recently showed that Elovl2 expression in beta cells, which regulates synthesis of endogenous DHA, was associated with gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9342f430169159099cb0c2b14924ed
https://hal.archives-ouvertes.fr/hal-02122657

Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity

Autor: Paola Giussani, Christophe Magnan, Carl K.-Y. Ng, Julien Véret, Lara Bellini, Hervé Le Stunff

Publikováno v: Journal of Clinical Medicine, Vol 3, Iss 2, Pp 646-662 (2014)
Journal of Clinical Medicine

Pancreatic β cells secrete insulin in order to maintain glucose homeostasis. However, various environmental stresses such as obesity have been shown to induce loss of secretory responsiveness in pancreatic β cells and pancreatic β cell apoptosis w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecda257c04b9f1c0c8eeb72a3b4015bd
http://www.mdpi.com/2077-0383/3/2/646

Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes

Autor: Mélanie Campana, Hervé Le Stunff, Julien Véret, Aurélie Carlier, Christophe Magnan, Rana Mahfouz, Eric Hajduch, Lara Bellini

Publikováno v: Expert Opinion on Therapeutic Targets
Expert Opinion on Therapeutic Targets, Taylor & Francis, 2015, 19 (8), pp.1037-1050. ⟨10.1517/14728222.2015.1028359⟩
Expert Opinion on Therapeutic Targets, 2015, 19 (8), pp.1037-1050. ⟨10.1517/14728222.2015.1028359⟩

Obesity is a major factor that is linked to the development of type 2 diabetes (T2D). Excess circulating fatty acids (FAs), which characterize obesity, induce insulin resistance, steatosis, β cells dysfunction and apoptosis. These deleterious effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53689319295791e174292d2fd1d7bbd
https://hal.archives-ouvertes.fr/hal-02450878

Role of the sphingolipid biostat in pancreatic βcell apoptosis induced by gluco‐lipotoxicity

Autor: Nicolas Coant, Hervé Le Stunff, Paola Giussani, Bernard Portha, Evgeny Berdyshev, Julien Véret

Publikováno v: The FASEB Journal. 27

Accumulated evidence suggests that Type 2 diabetes is often associated with abnormalities in lipids metabolism. Adverse effects of fatty acids on β cell function and viability are potentiated by th...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bed24aa4d6b8d28805686d13ed009cd0
https://doi.org/10.1096/fasebj.27.1_supplement.1010.1