Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Julien Thevenet"'
Autor:
Fabian Wirth, Fabrice D. Heitz, Christine Seeger, Ioana Combaluzier, Karin Breu, Heather C. Denroche, Julien Thevenet, Melania Osto, Paolo Arosio, Julie Kerr-Conte, C. Bruce Verchere, François Pattou, Thomas A. Lutz, Marc Y. Donath, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated
Externí odkaz:
https://doaj.org/article/68eb80d31bdf42208e648a12724a93bf
Autor:
Lorea Zubiaga, Olivier Briand, Florent Auger, Veronique Touche, Thomas Hubert, Julien Thevenet, Camille Marciniak, Audrey Quenon, Caroline Bonner, Simon Peschard, Violeta Raverdy, Mehdi Daoudi, Julie Kerr-Conte, Gianni Pasquetti, Hermann Koepsell, Daniela Zdzieblo, Markus Mühlemann, Bernard Thorens, Nathalie D. Delzenne, Laure B. Bindels, Benoit Deprez, Marie C. Vantyghem, Blandine Laferrère, Bart Staels, Damien Huglo, Sophie Lestavel, François Pattou
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106057- (2023)
Summary: Metformin (MET) is the most prescribed antidiabetic drug, but its mechanisms of action remain elusive. Recent data point to the gut as MET’s primary target. Here, we explored the effect of MET on the gut glucose transport machinery. Using
Externí odkaz:
https://doaj.org/article/a2d8b736d8cd49a09e2f84d1fd3fac11
Autor:
Valery Gmyr, Caroline Bonner, Ericka Moerman, Antoine Tournoys, Nathalie Delalleau, Audrey Quenon, Julien Thevenet, Mikael Chetboun, Julie Kerr-Conte, François Pattou, Thomas Hubert, Merce Jourdain M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Human islet transplantation is a viable treatment option for type 1 diabetes mellitus (T1DM). However, pancreatic islet inflammation after transplantation induced by innate immune responses is likely to hinder graft function. This is mediated by inco
Externí odkaz:
https://doaj.org/article/f5de30a239f743ffa2e9bd4344aef351
Autor:
Valery Gmyr, Caroline Bonner, Bruno Lukowiak, Valerie Pawlowski, Nathalie Dellaleau, Sandrine Belaich, Isanga Aluka, Ericka Moermann, Julien Thevenet, Rimed Ezzouaoui, Gurvan Queniat, Francois Pattou, Julie Kerr-Conte Ph.D.
Publikováno v:
Cell Transplantation, Vol 24 (2015)
Reliable assessment of islet viability, mass, and purity must be met prior to transplanting an islet preparation into patients with type 1 diabetes. The standard method for quantifying human islet preparations is by direct microscopic analysis of dit
Externí odkaz:
https://doaj.org/article/376b35dc050e446c94e9a272f5de9fac
Publikováno v:
Laboratory Animals. 55:408-416
Diabetes cell therapy by human islet transplantation can restore an endogenous insulin secretion and normal glycaemic control in type 1 diabetic patients for as long as 10 years post transplantation. Before transplantation, each clinical islet prepar
Autor:
ANA ACOSTA-MONTALVO, CHIARA SAPONARO, JULIEN THEVENET, MAGALI CHIRAL, ANTHONY PIRON, NATHALIE DELALLEAU, GIANNI PASQUETTI, ANAÏS CODDEVILLE, MARIA MORENO, VALERY GMYR, MIRIAM CNOP, JULIE A. KERR-CONTE, FRANCOIS PATTOU, MARCO PONTOGLIO, ADRIAN LISTON, CAROLINE BONNER
Publikováno v:
Diabetes. 71
Hepatocyte Nuclear Factor-1A (HNF1A) is a master regulator of key glucose-responsive genes in metabolic organs such as the intestine, liver, kidney, and pancreas. Heterozygous mutations in HNF1A cause Maturity-Onset-Diabetes-of-the-Young (HNF1A-MODY)
Autor:
Julie Kerr-Conte, Julien Thevenet, Adeline Page, Vanessa Dehennaut, Céline Schulz, Gérard Vergoten, Ninon Very, Tony Lefebvre, Ikram El Yazidi-Belkoura, Amélie Decourcelle, Madjid Djouina, Stéphan Hardivillé
Publikováno v:
Oncogene
Oncogene, 2021, 41 (5), pp.745-756. ⟨10.1038/s41388-021-02121-9⟩
Oncogene, 2021, Oncogene, ⟨10.1038/s41388-021-02121-9⟩
Oncogene, 2021, 41 (5), pp.745-756. ⟨10.1038/s41388-021-02121-9⟩
Oncogene, 2021, Oncogene, ⟨10.1038/s41388-021-02121-9⟩
International audience; Alteration of O-GlcNAcylation, a dynamic post-translational modification, is associated with tumorigenesis and tumor progression. Its role in chemotherapy response is poorly investigated. Standard treatment for colorectal canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd1130c3433118e2f09d8bacc464a18
https://hal.science/hal-03770824
https://hal.science/hal-03770824
Autor:
Karin Breu, Heather Denroche, Melania Osto, C. B. Verchere, François Pattou, Christoph Hock, Jan Grimm, Fabrice Heitz, Julien Thevenet, Ioana Combaluzier, Fabian Wirth, Paolo Arosio, Thomas A. Lutz, Christine Seeger, Roger M. Nitsch, Julie Kerr-Conte, Marc Y. Donath
In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::952a93f7a1a78a328b53d1974486a1e8
https://doi.org/10.21203/rs.3.rs-147509/v1
https://doi.org/10.21203/rs.3.rs-147509/v1
Autor:
Julien Thevenet, Clara Clabaut, François Pattou, Caroline Bonner, Pauline Petit, Sofia Gargani, Julie Kerr-Conte, Valery Gmyr, Gianni Pasquetti
Publikováno v:
Diabetes. 69
A translational discrepancy exists between animal models used for diabetes research and diabetes in man, thus human relevant models must become a priority. We showed that collectively human islet grafts from 26 donors statistically significantly adap
Autor:
Magali Chiral, Caroline Bonner, Ioannis Spiliotis, Marco Pontoglio, C. Saponaro, Jochen H. M. Prehn, Julien Thevenet, Gianni Pasquetti, Lia Anguelova, Anthony Piron, Katharine R. Owen, Miriam Cnop, Valery Gmyr, Julie Kerr-Conte, Ana Acosta-Montalvo, François Pattou
Publikováno v:
Diabetes. 69
Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). Carriers are normoglycemic in childhood, but with age, they develop hyperglycemia associated with insulin secretory defects and beta cell dysfunction. Although endogenous glu