Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Julien Scesa"'
Autor:
Marc Bigaud, Achim Schlapbach, Ina Dix, Ralf Endres, Jean Quancard, Jutta Blank, Frédéric Bornancin, Markus Wartmann, Julien Scesa, Paulo Antonio Fernandes Gomes Dos Santos, Eva Altmann, Thomas Radimerski, Guido Bold, Nicole Buschmann, Samu Melkko, Andreas Weiss, Paul W. Manley, P. Erbel, Oliver Simic, Thomas Zoller, Catherine H. Régnier, Ansgar Schuffenhauer, Elisabeth Buchdunger, Martin Renatus, Paul M.J. McSheehy, Carole Pissot Soldermann
Publikováno v:
Journal of Medicinal Chemistry. 63:14576-14593
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9969a4c36550186a210fdfae8c1af415
https://doi.org/10.1021/acs.jmedchem.0c01245
https://doi.org/10.1021/acs.jmedchem.0c01245
Autor:
Carole, Pissot Soldermann, Oliver, Simic, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Markus, Wartmann, Marc, Bigaud, Andreas, Weiss, Paul, McSheehy, Ralf, Endres, Paulo, Santos, Jutta, Blank, Ansgar, Schuffenhauer, Guido, Bold, Nicole, Buschmann, Thomas, Zoller, Eva, Altmann, Paul W, Manley, Ina, Dix, Elisabeth, Buchdunger, Julien, Scesa, Jean, Quancard, Achim, Schlapbach, Frédéric, Bornancin, Thomas, Radimerski, Catherine H, Régnier
Publikováno v:
Journal of medicinal chemistry. 63(23)
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c9148f487b1a8d48b0cb731fa2d9337
https://pubmed.ncbi.nlm.nih.gov/33252239
https://pubmed.ncbi.nlm.nih.gov/33252239
Autor:
Peter Drueckes, Clive Mccarthy, Catherine H. Régnier, Giorgio Ottaviani, Janitha Reetz, Marc Gerspacher, Fabienne Baffert, Francesca Blasco, Philipp Holzer, Christoph Gaul, Julien Scesa, Eric Vangrevelinghe, Pascal Furet, Carole Pissot-Soldermann, Flavio Ossola, Gisele A. Tavares, Thomas Radimerski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2609-2613
We have designed and synthesized a novel series of 2,8-diaryl-quinoxalines as Janus kinase 2 inhibitors. Many of the inhibitors show low nanomolar activity against JAK2 and potently suppress proliferation of SET-2 cells in vitro. In addition, compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e8040e7496635b96d43623d28ff732
https://doi.org/10.1016/j.bmcl.2010.02.056
https://doi.org/10.1016/j.bmcl.2010.02.056