Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Julien Puyal"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-15 (2024)
Abstract Macroautophagy (hereafter called autophagy) is an essential physiological process of degradation of organelles and long-lived proteins. The discovery of autosis, a Na+/K+-ATPase (ATP1)-dependent type of autophagic cell death with specific mo
Externí odkaz:
https://doaj.org/article/ff765e35fe0c4533b7ab69e1caabc369
Autor:
Evgeniya Trofimenko, Gianvito Grasso, Mathieu Heulot, Nadja Chevalier, Marco A Deriu, Gilles Dubuis, Yoan Arribat, Marc Serulla, Sebastien Michel, Gil Vantomme, Florine Ory, Linh Chi Dam, Julien Puyal, Francesca Amati, Anita Lüthi, Andrea Danani, Christian Widmann
Publikováno v:
eLife, Vol 10 (2021)
Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules. The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered that KCNQ5, KCNN4, and KCNK5 potassium channel
Externí odkaz:
https://doaj.org/article/98b234728cca409a8a4e7ab3072baed6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Despite tremendous advances in neonatal intensive care over the past 20 years, prematurity carries a high burden of neurological morbidity lasting lifelong. The term encephalopathy of prematurity (EoP) coined by Volpe in 2009 encompasses all aspects
Externí odkaz:
https://doaj.org/article/15b08ee4d63649e8a5127bd750732eb5
Autor:
Delphine Balmer, Martine Emery, Pénélope Andreux, Johan Auwerx, Vanessa Ginet, Julien Puyal, Daniel F Schorderet, Raphaël Roduit
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74162 (2013)
Glucose is an important metabolic substrate of the retina and diabetic patients have to maintain a strict normoglycemia to avoid diabetes secondary effects, including cardiovascular disease, nephropathy, neuropathy and retinopathy. Others and we rece
Externí odkaz:
https://doaj.org/article/92fdd53aac3d47d496ad86f7c7419976
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71721 (2013)
Lactate is increasingly described as an energy substrate of the brain. Beside this still debated metabolic role, lactate may have other effects on brain cells. Here, we describe lactate as a neuromodulator, able to influence the activity of cortical
Externí odkaz:
https://doaj.org/article/b1189d6593ce44df9772996f8c428b16
Autor:
Nadia Rosenberg, Maria Reva, Francesca Binda, Leonardo Restivo, Pauline Depierre, Julien Puyal, Marc Briquet, Yann Bernardinelli, Anne‐Bérengère Rocher, Henry Markram, Jean‐Yves Chatton
Publikováno v:
Glia, vol. 71, no. 4, pp. 957-973
Alzheimer's disease (AD) is becoming increasingly prevalent worldwide. It represents one of the greatest medical challenges as no pharmacologic treatments are available to prevent disease progression. Astrocytes play crucial functions within neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f55053e7a0339af69a3954befb63d9
https://doi.org/10.1002/glia.24317
https://doi.org/10.1002/glia.24317
Autor:
Lluis Fajas, Isabel C. Lopez-Mejia, Pedro Romero, Lianjun Zhang, Angélique Pabois, Anita Nasrallah, Valentin Barquissau, Catherine Moret, Oleksandr Dergai, Albert Giralt, Judit Castillo-Armengol, Meritxell Orpinell, Lucía C. Leal-Esteban, Julien Puyal, Laia Martínez-Carreres
Supplementary Figures and Supplementary Figure legends. Supplementary Fig. 1.- CDK4 inhibition or depletion decreases mTORC1 activity in several cancer cell lines, Supplementary Fig. 2.- CDK4 effects on mTORC1 are α-ketoglutarate and E2F1-independen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab448ab8dcf5d7f5550bd63893fa293
https://doi.org/10.1158/0008-5472.22422338.v1
https://doi.org/10.1158/0008-5472.22422338.v1
Autor:
Lluis Fajas, Isabel C. Lopez-Mejia, Pedro Romero, Lianjun Zhang, Angélique Pabois, Anita Nasrallah, Valentin Barquissau, Catherine Moret, Oleksandr Dergai, Albert Giralt, Judit Castillo-Armengol, Meritxell Orpinell, Lucía C. Leal-Esteban, Julien Puyal, Laia Martínez-Carreres
Cyclin-dependent kinase 4 (CDK4) is well-known for its role in regulating the cell cycle, however, its role in cancer metabolism, especially mTOR signaling, is undefined. In this study, we established a connection between CDK4 and lysosomes, an emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c42bc5713c371dfadfd076bd4869d2
https://doi.org/10.1158/0008-5472.c.6511187.v1
https://doi.org/10.1158/0008-5472.c.6511187.v1
Autor:
Lluis Fajas, Isabel C. Lopez-Mejia, Pedro Romero, Lianjun Zhang, Angélique Pabois, Anita Nasrallah, Valentin Barquissau, Catherine Moret, Oleksandr Dergai, Albert Giralt, Judit Castillo-Armengol, Meritxell Orpinell, Lucía C. Leal-Esteban, Julien Puyal, Laia Martínez-Carreres
Supplementary Tables. Supplementary Table 1. Target sequences for guide RNA used to create KO stable cell lines with CRISP/Cas9 technology, Supplementary Table 2. Primers used for qPCR Analysis of Transcription Factor EB (TFEB) regulated genes (human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3ca4568c0e323d04ed13310ca03531
https://doi.org/10.1158/0008-5472.22422335
https://doi.org/10.1158/0008-5472.22422335
Autor:
Lluis Fajas, Isabel C. Lopez-Mejia, Pedro Romero, Lianjun Zhang, Angélique Pabois, Anita Nasrallah, Valentin Barquissau, Catherine Moret, Oleksandr Dergai, Albert Giralt, Judit Castillo-Armengol, Meritxell Orpinell, Lucía C. Leal-Esteban, Julien Puyal, Laia Martínez-Carreres
Supplementary Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e49fd7697b08c25aa0cf84e4d26a2a0
https://doi.org/10.1158/0008-5472.22422341.v1
https://doi.org/10.1158/0008-5472.22422341.v1