Ring-opening carbonyl–olefin metathesis of norbornenes†

Autor: Tristan H. Lambert, Julien Pomarole, Phong K. Quach, Janis Jermaks, Zara M. Seibel

Publikováno v: Chemical Science

A computational and experimental study of the hydrazine-catalyzed ring-opening carbonyl–olefin metathesis of norbornenes is described. Detailed theoretical investigation of the energetic landscape for the full reaction pathway with six different hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f508dcc15bc88c029fc842cf9dfd8515
http://europepmc.org/articles/PMC8163149

Enabling nucleophilic substitution reactions of activated alkyl fluorides through hydrogen bonding

Autor: Julien Pomarole, Samuel Beaulieu, Pier Alexandre Champagne, Jean-François Paquin, Yasmine Benhassine, Claude Y. Legault, Marie Ève Thérien

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2013, 15, pp.2210-2213. ⟨10.1021/ol400765a⟩
Organic Letters, 2013, 15, pp.2210-2213. ⟨10.1021/ol400765a⟩

International audience; It was discovered that the presence of water as a cosolvent enables the reaction of activated alkyl fluorides for bimolecular nucleophilic substitution reactions. DFT calculations show that activation proceeds through stabiliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319f110feddb901618467cb31858a24d
https://pubmed.ncbi.nlm.nih.gov/23614350