Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Julien Papillon"'
Autor:
Matthew D. Shirley, Julie T. Chen, Ailing Li, Anthony Vattay, David A. Ruddy, Anka Bric, Kay X. Xiang, Simon Mathieu, Troy Smith, Julien Papillon, Deborah Castelletti, Rukundo Ntaganda, Kathleen Sprouffske, Hyo-eun C. Bhang, Yun Feng, Dorothee Abramowski, Ali Farsidjani, Audrey Kauffmann, Grainne Kerr, Aurore Desplat, Geoffrey Bushold, Katsumasa Nakajima, Henrik Möbitz, GiNell Elliott, Christopher D. Adair, Zainab Jagani, Florencia Rago
Publikováno v:
Molecular Cancer Therapeutics. 19:2186-2195
Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies and very few effective treatments for this cancer. Although activating mutations in the G protein alpha subunits, GNAQ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834a4bf4bd6c499cad099714441dcd05
https://doi.org/10.1158/1535-7163.mct-19-1013
https://doi.org/10.1158/1535-7163.mct-19-1013
Autor:
Julien Papillon, Christopher M. Adams
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783030566180
Glaucoma is one of the leading causes of irreversible blindness globally, with over 75.0 million people anticipated to be affected in 2020 with that number growing to over 110 million in 2040. The prevalence of glaucoma coupled with the unfortunate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e56a2813b1c2dc82a237bf5b538ccd
https://doi.org/10.1007/7355_2019_92
https://doi.org/10.1007/7355_2019_92
Autor:
Julien Papillon, Rajeshri Ganesh Karki, Gregg Chenail, Zainab Jagani, Raviraj Kulathila, Xiaoling Xie, Henrik Möbitz, John Cantwell, Tiancen Hu, Xiaoping Zhu, Felipe Kellermann Hurtado, Tamara J. Gilbert, Anthony Vattay, Daniel King, Hyo-eun C. Bhang, Emily A. Costa, Katsumasa Nakajima, Susan E. Hill, Q. Kimberley Yue, Catherine Luu, Rukundo Ntaganda, Christopher D. Adair, Michael Scott Visser, Jonathan E. Hempel, David Farley, Ailing Li, Anka Bric, Simon Mathieu, Troy Smith, Geoffrey Bushold, Eugen Lounkine, Andriana Jouk, Isabel Park, Katarina Vulic, Kay Xiang, Julie Dooley
Publikováno v:
Journal of Medicinal Chemistry. 61:10155-10172
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2), also known as Brahma homologue (BRM), is a Snf2-family DNA-dependent ATPase. BRM and its close homologue Brahma-related gene 1 (BRG1), also kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82980a2b96152a3795980e644fee3da5
https://doi.org/10.1021/acs.jmedchem.8b01318
https://doi.org/10.1021/acs.jmedchem.8b01318
Autor:
Julien Papillon, Mark A. Gilchrist, Meihui Pan, Alok K. Singh, James Thompson, Margaret E. Brousseau, Changgang Lou, Todd Stawicki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3514-3517
We designed and prepared synthetic phospholipids that generate lyso-phosphatidylcholine products with a unique mass for convenient detection by LC-MS in complex biological matrices. We demonstrated that compound 4, formulated either as a Triton X-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988e5ba2b7566e5ca800d194f21b3142
https://doi.org/10.1016/j.bmcl.2016.06.032
https://doi.org/10.1016/j.bmcl.2016.06.032
Autor:
Laura Axford, Micah Hollis-Symynkywicz, Jovita Marcinkeviciene, Lac Lee, Julien Papillon, Tyler Harrison, Jean Regard, Xianglin Ren, Lin Deng, Lawrence G. Hamann, Evan Cohick, Sally Loi, Sam Kecman, Martin L. Marro, Natalie Dales, Andrew Patterson, Anup Patnaik
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115548
Myeloperoxidase (MPO) activity and subsequent generation of hypochlorous acid has been associated with the killing of host-invading microorganisms (e.g. bacteria, viruses, and fungi). However, during oxidative stress, high MPO activity can damage hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa62aeab41b2bdf6e6218857945f77cb
https://doi.org/10.1016/j.bmc.2020.115548
https://doi.org/10.1016/j.bmc.2020.115548
Autor:
Sally Loi, Lac Lee, Jean Regard, Dominique Custeau, Andrew Patterson, Lin Deng, Julien Papillon, Aimee Reynolds, Tyler Harrison, Micah Hollis-Symynkywicz, Jovita Marcinkeviciene, Lawrence G. Hamann, Anup Patnaik, Xianglin Ren, Jutta Blank, Nigel Casson, Laura Axford, Toshiyuki Honda, Lisa Ames, Lihe Zhang, Martin L. Marro
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(1)
Myeloperoxidase (MPO) is a leukocyte-derived redox enzyme that has been linked to oxidative stress and damage in many inflammatory states, including cardiovascular disease. We have discovered aminopyridines that are potent mechanism-based inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444de565ea988076b4b032134228dce7
https://pubmed.ncbi.nlm.nih.gov/30076263
https://pubmed.ncbi.nlm.nih.gov/30076263
Autor:
Dean F. Rigel, Kerry S. Russell, Lu Gan, Julien Papillon, Chii-Whei Hu, Changgang Lou, Alok K. Singh, Daniel LaSala, Wei Chen, Gary Michael Ksander, Fumin Fu, Catherine Watson, Jennifer Leung-Chu, Arco Y. Jeng, Christopher M. Adams, Guiqing Liang, John A. Vest, Michael E. Beil
Publikováno v:
Journal of Medicinal Chemistry. 58:9382-9394
Human clinical studies conducted with LCI699 established aldosterone synthase (CYP11B2) inhibition as a promising novel mechanism to lower arterial blood pressure. However, LCI699's low CYP11B1/CYP11B2 selectivity resulted in blunting of adrenocortic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e6c50d8e5e31a37972d238e9fe1c8c
https://doi.org/10.1021/acs.jmedchem.5b01545
https://doi.org/10.1021/acs.jmedchem.5b01545
Autor:
Jose Carvalho, Arco Y. Jeng, Gary Michael Ksander, Michael Logman, Eric Gangl, Changgang Lou, Adam Amaral, Sherri Smith, Daniel LaSala, Julien Papillon, Fumin Fu, Srinivan Rajan, Chii-Whei Hu, Qi-Ying Hu, Guiqing Liang, Chun Zhang, Alok K. Singh, Michael E. Beil, Wieslawa Maniara, Christopher M. Adams, Dean F. Rigel
Publikováno v:
Journal of medicinal chemistry. 58(11)
CYP11B2, the aldosterone synthase, and CYP11B1, the cortisol synthase, are two highly homologous enzymes implicated in a range of cardiovascular and metabolic diseases. We have previously reported the discovery of LCI699, a dual CYP11B2 and CYP11B1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae31b3435b92f18b555f524e3460454
https://pubmed.ncbi.nlm.nih.gov/25953419
https://pubmed.ncbi.nlm.nih.gov/25953419
Publikováno v:
Synthetic Metals. 96:155-160
The aim of this work is the electrochemical synthesis of a new type of material possessing the properties of organic conductive polymers along with those of organometallic complexes, for their use in asymmetric heterogeneous catalysis. The synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5e3fe37b55fe94453369f8cc47e08ef
https://doi.org/10.1016/s0379-6779(98)00091-5
https://doi.org/10.1016/s0379-6779(98)00091-5
Autor:
Erik Meredith, Michael Paul Capparelli, Gary Michael Ksander, Chang Rao, Robin Burgis, Julien Papillon, Lauren G. Monovich, Dean F. Rigel, Alok K. Singh, Arco Y. Jeng, Chii-Whei Hu, Karl Miranda, Daniel LaSala, Qian Liu, Fumin Fu, Michael E. Beil, Qi-Ying Hu, Patrick J. Morris
Publikováno v:
ACS medicinal chemistry letters. 4(12)
Aldosterone is a key signaling component of the renin-angiotensin-aldosterone system and as such has been shown to contribute to cardiovascular pathology such as hypertension and heart failure. Aldosterone synthase (CYP11B2) is responsible for the fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dde8962d19a1a500167875ed7ff669
https://pubmed.ncbi.nlm.nih.gov/24900631
https://pubmed.ncbi.nlm.nih.gov/24900631