Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology

Autor: Charlotte Duwat, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, Caroline Jan, Pauline Gipchtein, Julien Mitja, Stéphane Fouquet, Marie-Laure Niepon, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Karine Cambon, Alexis-Pierre Bemelmans

Publikováno v: Neurobiology of Disease, Vol 181, Iss , Pp 106116- (2023)

Tauopathy is a typical feature of Alzheimer's disease of major importance because it strongly correlates with the severity of cognitive deficits experienced by patients. During the pathology, it follows a characteristic spatiotemporal course which ta

Externí odkaz: https://doaj.org/article/6df829acc824451a93ba913807abbb2e

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Autor: Noémie Cresto, Marie-Claude Gaillard, Camille Gardier, Francesco Gubinelli, Elsa Diguet, Déborah Bellet, Laurine Legroux, Julien Mitja, Gwenaëlle Auregan, Martine Guillermier, Charlène Josephine, Caroline Jan, Noëlle Dufour, Alain Joliot, Philippe Hantraye, Gilles Bonvento, Nicole Déglon, Alexis-Pierre Bemelmans, Karine Cambon, Géraldine Liot, Emmanuel Brouillet

Publikováno v: Neurobiology of Disease, Vol 134, Iss , Pp - (2020)

The G2019S substitution in the kinase domain of LRRK2 (LRRK2G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2G2019S are thought to result from an increase in its kinase activity as compared t

Externí odkaz: https://doaj.org/article/f99d8776c12c4a7bb6880f866319890e

THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

Autor: Emmanuel Brouillet, Luc Buée, Gilles Bonvento, Alexis-Pierre Bemelmans, Julien Mitja, Charlotte Duwat, Charlène Joséphine, Karine Cambon, David Blum, Anne-Sophie Hérard, Pauline Gipchtein, Gwennaëlle Aurégan, Marie-Claude Gaillard, Audrey Vautheny, Philippe Hantraye, Caroline Jan

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2021, 155, pp.105398. ⟨10.1016/j.nbd.2021.105398⟩
Neurobiology of Disease, 2021, 155, pp.105398. ⟨10.1016/j.nbd.2021.105398⟩
Neurobiology of Disease, Vol 155, Iss, Pp 105398-(2021)

International audience; The role played by microglia has taken the center of the stage in the etiology of Alzheimer's disease (AD). Several genome-wide association studies carried out on large cohorts of patients have indeed revealed a large number o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e476bd7271aa1064033afc43759b5a
https://doi.org/10.1016/j.nbd.2021.105398