Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Julien Marcoux"'
Autor:
Sophie Tagnères, Paulo Espirito Santo, Julie Radermecker, Dana Rinaldi, Carine Froment, Quentin Provost, Manon Bongers, Solemne Capeille, Nick Watkins, Julien Marcoux, Pierre-Emmanuel Gleizes, Virginie Marcel, Célia Plisson-Chastang, Simon Lebaron
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Cancer cells rely on high ribosome production to sustain their proliferation rate. Many chemotherapies impede ribosome production which is perceived by cells as “nucleolar stress” (NS), triggering p53-dependent and independent pathways l
Externí odkaz:
https://doaj.org/article/fd1b3098e42d421d8ee03f99b039a140
LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry
Autor:
Yiying Yang, Haoxiang Chen, Robin A. Corey, Violette Morales, Yves Quentin, Carine Froment, Anne Caumont-Sarcos, Cécile Albenne, Odile Burlet-Schiltz, David Ranava, Phillip J. Stansfeld, Julien Marcoux, Raffaele Ieva
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Insertion of lipopolysaccharide (LPS) into the bacterial outer membrane (OM) is mediated by a druggable OM translocon consisting of a β-barrel membrane protein, LptD, and a lipoprotein, LptE. The β-barrel assembly machinery (BAM) assembles
Externí odkaz:
https://doaj.org/article/ed9b9dea67df414eaaab40bf034d319b
Autor:
Stephen Adonai Leon-Icaza, Salimata Bagayoko, Romain Vergé, Nino Iakobachvili, Chloé Ferrand, Talip Aydogan, Célia Bernard, Angelique Sanchez Dafun, Marlène Murris-Espin, Julien Mazières, Pierre Jean Bordignon, Serge Mazères, Pascale Bernes-Lasserre, Victoria Ramé, Jean-Michel Lagarde, Julien Marcoux, Marie-Pierre Bousquet, Christian Chalut, Christophe Guilhot, Hans Clevers, Peter J Peters, Virginie Molle, Geanncarlo Lugo-Villarino, Kaymeuang Cam, Laurence Berry, Etienne Meunier, Céline Cougoule
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011559 (2023)
Mycobacterium abscessus (Mabs) drives life-shortening mortality in cystic fibrosis (CF) patients, primarily because of its resistance to chemotherapeutic agents. To date, our knowledge on the host and bacterial determinants driving Mabs pathology in
Externí odkaz:
https://doaj.org/article/dd6af14953434ec98b532b99ba43fe5d
Autor:
Cécile Bon, Stéphanie Cabantous, Sylviane Julien, Valérie Guillet, Christian Chalut, Julie Rima, Yoann Brison, Wladimir Malaga, Angelique Sanchez-Dafun, Sabine Gavalda, Annaïk Quémard, Julien Marcoux, Geoffrey S. Waldo, Christophe Guilhot, Lionel Mourey
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Type I polyketide synthases (PKSs) are multifunctional enzymes responsible for the biosynthesis of a group of diverse natural compounds with biotechnological and pharmaceutical interest called polyketides. The diversity of polyket
Externí odkaz:
https://doaj.org/article/ce957ac87b34489ba429e3036d0705f9
Autor:
Pascal Demange, Etienne Joly, Julien Marcoux, Patrick RA Zanon, Dymytrii Listunov, Pauline Rullière, Cécile Barthes, Céline Noirot, Jean-Baptiste Izquierdo, Alexandrine Rozié, Karen Pradines, Romain Hee, Maria Vieira de Brito, Marlène Marcellin, Remy-Felix Serre, Olivier Bouchez, Odile Burlet-Schiltz, Maria Conceição Ferreira Oliveira, Stéphanie Ballereau, Vania Bernardes-Génisson, Valérie Maraval, Patrick Calsou, Stephan M Hacker, Yves Génisson, Remi Chauvin, Sébastien Britton
Publikováno v:
eLife, Vol 11 (2022)
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that t
Externí odkaz:
https://doaj.org/article/793efaee61f44925b2fa3f2f6920aeac
Autor:
Romain Darrigrand, Alison Pierson, Marine Rouillon, Dolor Renko, Mathilde Boulpicante, David Bouyssié, Emmanuelle Mouton-Barbosa, Julien Marcoux, Camille Garcia, Michael Ghosh, Mouad Alami, Sébastien Apcher
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Darrigrand, Pierson et al. study the effect of mRNA splicing inhibitors on the generation of the MHC class I ligands. They developed a derivative of the spliceosome inhibitor isoginkgetin which is less toxic and more effective at enhancing antigen pr
Externí odkaz:
https://doaj.org/article/1c8392da73b6409daf3965425089b16d
Autor:
Angelique Sanchez Dafun, Dušan Živković, Stephen Adonai Leon-Icaza, Sophie Möller, Carine Froment, Delphine Bonnet, Adriana Almeida de Jesus, Laurent Alric, Muriel Quaranta-Nicaise, Audrey Ferrand, Céline Cougoule, Etienne Meunier, Odile Burlet-Schiltz, Frédéric Ebstein, Raphaela Goldbach-Mansky, Elke Krüger, Marie-Pierre Bousquet, Julien Marcoux
Publikováno v:
Cells, Vol 12, Iss 6, p 844 (2023)
The mammalian 20S catalytic core of the proteasome is made of 14 different subunits (α1-7 and β1-7) but exists as different subtypes depending on the cell type. In immune cells, for instance, constitutive catalytic proteasome subunits can be replac
Externí odkaz:
https://doaj.org/article/82a536a0dc864846a720b94a72410252
Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
Autor:
Jean Lesne, Marie Locard-Paulet, Julien Parra, Dušan Zivković, Thomas Menneteau, Marie-Pierre Bousquet, Odile Burlet-Schiltz, Julien Marcoux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard
Externí odkaz:
https://doaj.org/article/ed5d484ebb094784a4e9cc4583e3d0aa
Autor:
Valérie Guillet, Patricia Bordes, Cécile Bon, Julien Marcoux, Virginie Gervais, Ambre Julie Sala, Suzana Dos Reis, Nawel Slama, Israel Mares-Mejía, Anne-Marie Cirinesi, Laurent Maveyraud, Pierre Genevaux, Lionel Mourey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of t
Externí odkaz:
https://doaj.org/article/a3545627c95b4aebbc2831156701c6af
Autor:
David Ranava, Yiying Yang, Luis Orenday-Tapia, François Rousset, Catherine Turlan, Violette Morales, Lun Cui, Cyril Moulin, Carine Froment, Gladys Munoz, Jérôme Rech, Julien Marcoux, Anne Caumont-Sarcos, Cécile Albenne, David Bikard, Raffaele Ieva
Publikováno v:
eLife, Vol 10 (2021)
In Proteobacteria, integral outer membrane proteins (OMPs) are crucial for the maintenance of the envelope permeability barrier to some antibiotics and detergents. In Enterobacteria, envelope stress caused by unfolded OMPs activates the sigmaE (σE)
Externí odkaz:
https://doaj.org/article/ae751a6fa24f422790ef3368b1956333