Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Julien M D Legrand"'
Autor:
Bhavana Nayer, Jean L. Tan, Yasmin K. Alshoubaki, Yen-Zhen Lu, Julien M. D. Legrand, Sinnee Lau, Nan Hu, Anthony J. Park, Xiao-Nong Wang, Daniela Amann-Zalcenstein, Peter F. Hickey, Trevor Wilson, Gisela A. Kuhn, Ralph Müller, Ajithkumar Vasanthakumar, Shizuo Akira, Mikaël M. Martino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cells (Tregs) are crucial immune cells for tissue repair and regeneration. However, their potential as a cell-based regenerative therapy is not yet fully understood. Here, we show that local delivery of exogenous Tregs into inju
Externí odkaz:
https://doaj.org/article/f42f79ea96ac4536ad48ec4b75f69576
Autor:
Yasmin K. Alshoubaki, Yen-Zhen Lu, Julien M. D. Legrand, Rezvan Karami, Mathilde Fossat, Ekaterina Salimova, Ziad Julier, Mikaël M. Martino
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Among therapeutic proteins, cytokines and growth factors have great potential for regenerative medicine applications. However, these molecules have encountered limited clinical success due to low effectiveness and major safety concerns, high
Externí odkaz:
https://doaj.org/article/effeed46e01f4c4f806cc1a9a83a7ed6
Autor:
Hue M. La, Jinyue Liao, Julien M. D. Legrand, Fernando J. Rossello, Ai-Leen Chan, Vijesh Vaghjiani, Jason E. Cain, Antonella Papa, Tin Lap Lee, Robin M. Hobbs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Male germline regeneration after damage is dependent on spermatogonial stem cells (SSCs) but pathways mediating the regenerative response are unclear. Here the authors define roles for growth factor signalling and mTORC1 in SSC-driven regeneration.
Externí odkaz:
https://doaj.org/article/c5b786b3253b4ddfa4628cd3bcff83d1
Autor:
Julien M. D. Legrand, Ai-Leen Chan, Hue M. La, Fernando J. Rossello, Minna-Liisa Änkö, Frances V. Fuller-Pace, Robin M. Hobbs
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Sustained sperm production is dependent on activity of undifferentiated spermatogonia. Here, the authors demonstrate an essential role for RNA helicase DDX5 in maintenance of spermatogonia in adults through control of gene transcription plus RNA proc
Externí odkaz:
https://doaj.org/article/852498ee4d314917b02f782d466e190b
Autor:
Hue M. La, Juho-Antti Mäkelä, Ai-Leen Chan, Fernando J. Rossello, Christian M. Nefzger, Julien M. D. Legrand, Mia De Seram, Jose M. Polo, Robin M. Hobbs
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the transcr
Externí odkaz:
https://doaj.org/article/87e119b967464304a757f01694a020cf
Autor:
Qixuan Wang, Ji Won Oh, Hye-Lim Lee, Anukriti Dhar, Tao Peng, Raul Ramos, Christian Fernando Guerrero-Juarez, Xiaojie Wang, Ran Zhao, Xiaoling Cao, Jonathan Le, Melisa A Fuentes, Shelby C Jocoy, Antoni R Rossi, Brian Vu, Kim Pham, Xiaoyang Wang, Nanda Maya Mali, Jung Min Park, June-Hyug Choi, Hyunsu Lee, Julien M D Legrand, Eve Kandyba, Jung Chul Kim, Moonkyu Kim, John Foley, Zhengquan Yu, Krzysztof Kobielak, Bogi Andersen, Kiarash Khosrotehrani, Qing Nie, Maksim V Plikus
Publikováno v:
eLife, Vol 6 (2017)
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitabili
Externí odkaz:
https://doaj.org/article/c6e93715c39943c397d8d7d21e389963
Autor:
Sally Mortlock, Grant Morahan, N. Muller, Young S, Nicholas Matigian, Mark Morrison, Julien M. D. Legrand, B. Baz, Kiarash Khosrotehrani, K. Togher, Graeme J. Walker, Seungha Kang, J. Galbraith, Edwige Roy
Animal microbiota are shaped and maintained not only through microbiota-environmental interactions but also through host-microbiota interactions. The effects of the microbiota on the host has been the source of intense research in recent years, indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817356cc62664268de5134a8dd8d23d5
https://doi.org/10.1101/2021.06.20.449197
https://doi.org/10.1101/2021.06.20.449197
Autor:
Elliot Gerrard, Harald Janovjak, Alexandra Madelaine Tichy, Robin M. Hobbs, Julien M. D. Legrand
Publikováno v:
Journal of Molecular Biology. 431:3046-3055
Optogenetics enables the spatio-temporally precise control of cell and animal behavior. Many optogenetic tools are driven by light-controlled protein-protein interactions (PPIs) that are repurposed from natural light-sensitive domains (LSDs). Applyin
Autor:
Minna-Liisa Änkö, Frances V. Fuller-Pace, Hue M. La, Fernando J. Rossello, Robin M. Hobbs, Julien M. D. Legrand, Ai-Leen Chan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Nature Communications
Nature Communications
Mammalian spermatogenesis is sustained by mitotic germ cells with self-renewal potential known as undifferentiated spermatogonia. Maintenance of undifferentiated spermatogonia and spermatogenesis is dependent on tightly co-ordinated transcriptional a
Autor:
Julien M D, Legrand, Mikaël M, Martino
Publikováno v:
Cold Spring Harbor Perspectives in Biology. 14:a041234
Skin wound healing is a highly coordinated process involving multiple tissue-resident and recruited cell types. Cells within the wound microenvironment respond to key secreted factors such as pro-proliferative growth factors and immunomodulatory cyto