Inhibition of falcilysin from Plasmodium falciparum by interference with its closed-to-open dynamic transition

Autor: Jianqing Lin, Xinfu Yan, Zara Chung, Chong Wai Liew, Abbas El Sahili, Evgeniya V. Pechnikova, Peter R. Preiser, Zbynek Bozdech, Yong-Gui Gao, Julien Lescar

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Abstract In the absence of an efficacious vaccine, chemotherapy remains crucial to prevent and treat malaria. Given its key role in haemoglobin degradation, falcilysin constitutes an attractive target. Here, we reveal the mechanism of enzymatic inhib

Externí odkaz: https://doaj.org/article/884a7bfcc9134996806c5745785f14a6

On Fairness via Picking Sequences in Allocation of Indivisible Goods

Autor: Julien Lesca, Laurent Gourvès, Anaëlle Wilczynski

Publikováno v: 7th International Conference on Algorithmic Decision Theory (ADT-21)
7th International Conference on Algorithmic Decision Theory (ADT-21), Nov 2021, Toulouse, France. pp.258-272, ⟨10.1007/978-3-030-87756-9_17⟩
Algorithmic Decision Theory ISBN: 9783030877552
ADT

International audience; Among the fairness criteria for allocating indivisible resources to a group of agents, some are based on minimum utility levels. These levels can come from a specific allocation method, such as maximin fair-share criterion whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b89d77804b1054ed60aedd862d7a401
https://hal.archives-ouvertes.fr/hal-03406848

A Complexity Approach for Core-Selecting Exchange under Conditionally Lexicographic Preferences

Autor: Julien Lesca, Etsushi Fujita, Akihisa Sonoda, Taiki Todo, Makoto Yokoo

Publikováno v: Journal of Artificial Intelligence Research
Journal of Artificial Intelligence Research, Association for the Advancement of Artificial Intelligence, 2018, 63, pp.515-555. ⟨10.1613/jair.1.11254⟩

Core-selection is a crucial property of rules in the literature of resource allocation. It is also desirable, from the perspective of mechanism design, to address the incentive of agents to cheat by misreporting their preferences. This paper investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a6cbc1dc23a290c6133df07a0c1c9a
https://doi.org/10.1613/jair.1.11254

Defining neutralization and allostery by antibodies against COVID-19 variants

Autor: Nikhil Kumar Tulsian, Raghuvamsi Venkata Palur, Xinlei Qian, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Yee Hwa Wong, Jianqing Lin, Kiren Purushotorman, Mary McQueen Kozma, Bei Wang, Julien Lescar, Cheng-I Wang, Ravindra Kumar Gupta, Peter John Bond, Paul Anthony MacAry

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing antibodies is linked t

Externí odkaz: https://doaj.org/article/54f52c1fa0c948c5b812e8554189a002

On the Problem of Assigning PhD Grants

Autor: Julien Lesca, Laurent Gourvès, Katarína Cechlárová

Publikováno v: Proceedings of the Twenty-Eighth International Joint Conference on Artificial Intelligence (IJCAI 2019)
28th International Joint Conference on Artificial Intelligence (IJCAI 2019)
28th International Joint Conference on Artificial Intelligence (IJCAI 2019), Aug 2019, Macao, China. pp.130-136, ⟨10.24963/ijcai.2019/19⟩
IJCAI

International audience; In this paper, we study the problem of assigning PhD grants. Master students apply for PhD grants on different topics and the number of available grants is limited. In this problem, students have preferences over topics they a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c03f145bf30c5b5062409aff608fe30
https://hal.archives-ouvertes.fr/hal-02303512/document