Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Julien Lefranc"'
Autor:
Rienk Offringa, Ralf Lesche, Iris Oezen, Michael Platten, Daniel Baumann, Christiane A Opitz, Ahmed Sadik, Catherine Olesch, Frederik Cichon, Norbert Schmees, Ulrike Roehn, Florian Prinz, Detlef Stoeckigt, Katharina Sahm, Nirmeen Elmadany, Christina Kober, Julian Roewe, Lars Roese, Benjamin Bader, Mátyás Gorjánácz, Helge Gottfried Roider, Gabriele Leder, Horst Irlbacher, Julien Lefranc, Mine Oezcan-Wahlbrink, Ankita Sati Batra, Rafael Carretero, Hilmar Weinmann, Ingo V Hartung, Bertolt Kreft, Ilona Gutcher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background The metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and adaptive tumor immune resistance. The immunosuppressive effects of KYN in the tumor microen
Externí odkaz:
https://doaj.org/article/bc1e59d7b2b148a6869f255df5b9d454
Autor:
Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
Detailed method descriptions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b320e3c23f072f7d98b788ef8e1aa81
https://doi.org/10.1158/1535-7163.22507162
https://doi.org/10.1158/1535-7163.22507162
Autor:
Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
The DNA damage response (DDR) secures the integrity of the genome of eukaryotic cells. DDR deficiencies can promote tumorigenesis but concurrently may increase dependence on alternative repair pathways. The ataxia telangiectasia and Rad3-related (ATR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71b4129b5b767f4375ccfbccdc80fc9
https://doi.org/10.1158/1535-7163.c.6538606.v1
https://doi.org/10.1158/1535-7163.c.6538606.v1
Autor:
Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
Tables S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110985976c0032596d291c0c9cff1993
https://doi.org/10.1158/1535-7163.22507159
https://doi.org/10.1158/1535-7163.22507159
Autor:
Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
Figures S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cecdc7c4b3d24cb9b91927a1753418
https://doi.org/10.1158/1535-7163.22507165
https://doi.org/10.1158/1535-7163.22507165
Autor:
Eleonora Diamanti, María Méndez, Tatjana Ross, Christian A. Kuttruff, Julien Lefranc, Franca‐Maria Klingler, Franz von Nussbaum, Manfred Jung, Matthias Gehringer
Publikováno v:
ChemMedChem. 17
The Frontiers in Medicinal Chemistry (FiMC) meeting, which represents the largest international medicinal chemistry conference in Germany, took place from March 14supth/supto 16supth/sup2022 in a fully virtual format. Organized by the Division of Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97820a95bbbafb3ee93891b3d7904bd0
https://doi.org/10.1002/cmdc.202200419
https://doi.org/10.1002/cmdc.202200419
Autor:
Tian-Sheng Mei, Lei Wei, Ke-Jin Jiao, Simon Herbert, Dong Liu, Bing Sun, Cong Ma, Julien Lefranc, Zhao-Ran Liu
Publikováno v:
Angewandte Chemie. 133:9530-9535
A novel strategy for the N-arylation of NH-sulfoximines has been developed by merging nickel catalysis and electrochemistry (in an undivided cell), thereby providing a practical method for the construction of sulfoximine derivatives. Paired electroly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4560925d648c643b8ca7b854695fc218
https://doi.org/10.1002/ange.202016310
https://doi.org/10.1002/ange.202016310
Autor:
Andrea Hägebarth, Carl Friedrich Nising, Philip Lienau, Julien Lefranc, Benjamin Bader, Clara D. Christ, Volker K Schulze, Clara Lemos, Simon Holton, Tobias Heinrich, Ulf Bömer, Franz von Nussbaum, Hans Briem, Ekaterina Nevedomskaya, Simon J. Baumgart, Dominik Mumberg, Bernard Haendler, Marcus Bauser, Lara Kuhnke
Publikováno v:
Cellular Oncology. 44:581-594
5′ adenosine monophosphate-activated kinase (AMPK) is an essential regulator of cellular energy homeostasis and has been associated with different pathologies, including cancer. Precisely defining the biological role of AMPK necessitates the availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c3ebc06fe1821f53c3d1ac1c328fe0
https://doi.org/10.1007/s13402-020-00584-8
https://doi.org/10.1007/s13402-020-00584-8
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 628-632 (2013)
N-Alkenyl ureas and N-alkenyl carbamates, like other N-acyl enamines, are typically nucleophilic at their β-carbon. However, by incorporating an α-aryl substituent, we show that they will also undergo attack at the β-carbon by organolithium nucleo
Externí odkaz:
https://doaj.org/article/98982f7e816e403c974f2ecd63bc0665
Autor:
Volker Schulze, Franz von Nussbaum, Clara Lemos, Philip Lienau, Ulf Bömer, Clara Christ, Marcus Bauser, Carl Friedrich Nising, Simon J. Baumgart, Simon Holton, Tobias Heinrich, Hans Briem, Benjamin Bader, Bernard Haendler, Julien Lefranc, Andrea Hägebarth, Dominik Mumberg, Ekaterina Nevedomskaya, Lara Kuhnke
Background: 5´ adenosine monophosphate-activated kinase (AMPK) is an essential regulator of cellular energy homeostasis which has been associated with different pathologies, including cancer. Precisely defining the role of AMPK in these processes ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de28afe92f682da433e5d167b7b11ea8
https://doi.org/10.21203/rs.3.rs-47637/v1
https://doi.org/10.21203/rs.3.rs-47637/v1