Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Julien Lancelot"'
Publikováno v:
Energies, Vol 15, Iss 20, p 7759 (2022)
Demand-side management (DSM) is increasingly needed for answering electricity flexibility needs in the upcoming transformation of energy systems. Use of automation leads to better efficiency, but its acceptance is problematic since it is linked with
Externí odkaz:
https://doaj.org/article/0bb10b6c406b4d7d893d2cdb87e0a779
Autor:
Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S A Pereira, Gilbert Oliveira Silveira, David da Silva Pires, Sergio Verjovski-Almeida, Frank J Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes-Torres, Dina Robaa, Wolfgang Sippl, Raymond J Pierce, M Teresa Borrello, A Ganesan, Julien Lancelot, Silvana Thiengo, Monica Ammon Fernandez, Amanda Roberta Revoredo Vicentino, Marina Moraes Mourão, Fernanda Sales Coelho, Marcelo Rosado Fantappié
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008332 (2020)
Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ) and, due to mass treatment, the increasing risk of selecting for schistosome strains that are resistant to PZQ has alerted investigators to the urgent
Externí odkaz:
https://doaj.org/article/f432fe7b163b45aa9006ab8d3eb9c2cc
Autor:
Ming Jang Chua, Megan S.J. Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F. Späth, Eric Prina, Raymond J. Pierce, David P. Fairlie, Tina S. Skinner-Adams, Katherine T. Andrews
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 1, Pp 42-50 (2017)
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progres
Externí odkaz:
https://doaj.org/article/652ca88e8de1425aa193abfb8a20b233
Autor:
Marion Morel, Mathieu Vanderstraete, Katia Cailliau, Arlette Lescuyer, Julien Lancelot, Colette Dissous
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Iss 3, Pp 256-266 (2014)
Protein kinases (PKs) are one of the largest protein families in most eukaryotic organisms. These enzymes are involved in the control of cell proliferation, differentiation and metabolism and a large number of the anticancer drugs currently used are
Externí odkaz:
https://doaj.org/article/afb27b852fd44d539b91942edb0dddad
Autor:
Stéphanie Caby, Lucile Pagliazzo, Julien Lancelot, Jean-Michel Saliou, Nicolas Bertheaume, Raymond J Pierce, Emmanuel Roger
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 11, p e0006089 (2017)
Histone deacetylase 8 from Schistosoma mansoni (SmHDAC8) is essential to parasite growth and development within the mammalian host and is under investigation as a target for the development of selective inhibitors as novel schistosomicidal drugs. Alt
Externí odkaz:
https://doaj.org/article/696e0eac389341a382c3a8c4bcd14d61
Autor:
Raymond John Pierce, Florence Dubois-Abdesselem, Stéphanie Caby, Jacques Trolet, Julien Lancelot, Frédérik Oger, Nicolas Bertheaume, Emmanuel Roger
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 7, Pp 794-801 (2011)
Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objectiv
Externí odkaz:
https://doaj.org/article/cfa524fa51d14dedb3f20feab275eb4f
Autor:
Conrad V. Simoben, Dina Robaa, Alokta Chakrabarti, Karin Schmidtkunz, Martin Marek, Julien Lancelot, Srinivasaraghavan Kannan, Jelena Melesina, Tajith B. Shaik, Raymond J. Pierce, Christophe Romier, Manfred Jung, Wolfgang Sippl
Publikováno v:
Molecules, Vol 23, Iss 3, p 566 (2018)
A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the crysta
Externí odkaz:
https://doaj.org/article/73b1ffb88c724f2986fdfd1e0f2763f9
Autor:
Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Eduardo José Lopes Torres, Stephany Caby, Julien Lancelot, Mathieu Vanderstraete, Silviya D Furdas, Manfred Jung, Raymond J Pierce, Marcelo Rosado Fantappié
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004116 (2014)
Treatment and control of schistosomiasis relies on the only available drug, praziquantel, and the search for alternative chemotherapeutic agents is therefore urgent. Egg production is required for the transmission and immunopathology of schistosomias
Externí odkaz:
https://doaj.org/article/510576f87bbf475a8b1ca3e4cd56c6a8
Autor:
Julien Lancelot, Stéphanie Caby, Florence Dubois-Abdesselem, Mathieu Vanderstraete, Jacques Trolet, Guilherme Oliveira, Franz Bracher, Manfred Jung, Raymond J Pierce
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2428 (2013)
The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ de
Externí odkaz:
https://doaj.org/article/85fa3a168c024fb38009fac7e94d934d
Autor:
Martin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, Marina Moraes Mourão, Stéphanie Caby, Vincent Cura, Diana A Stolfa, Karin Schmidtkunz, Julien Lancelot, Luiza Andrade, Jean-Paul Renaud, Guilherme Oliveira, Wolfgang Sippl, Manfred Jung, Jean Cavarelli, Raymond J Pierce, Christophe Romier
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003645 (2013)
The treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma genus, depends on the intensive use of a single drug, praziquantel, which increases the likelihood of the development of drug-resistant parasite strains a
Externí odkaz:
https://doaj.org/article/8177e77a4c194daa95e03dd903b2b7f5