Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Julien LaFrance-Vanasse"'
Autor:
Shraddha S, Sadekar, Mayumi, Bowen, Hao, Cai, Samira, Jamalian, Hanine, Rafidi, Whitney, Shatz-Binder, Julien, Lafrance-Vanasse, Pamela, Chan, William J, Meilandt, Amy, Oldendorp, Alavattam, Sreedhara, Ann, Daugherty, Susan, Crowell, Kristin R, Wildsmith, Jasvinder, Atwal, Reina N, Fuji, Joshua, Horvath
Publikováno v:
Clinical Pharmacology & Therapeutics. 111:826-834
Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the tissues of the central nervous system (CNS) by circumventing the blood-brain barrier and blood-CSF barrier. Developing an effective CSF drug delivery strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd4af582ed8aa4819475cceff982f1d
https://doi.org/10.1002/cpt.2531
https://doi.org/10.1002/cpt.2531
Autor:
Juan Jenny Li, Yuwen Linda Lin, Saileta Prabhu, Kevin Lin, Suzie J. Scales, Gizette Sperinde, Shan Chung, Kathi Williams, Saloumeh K Fischer, James A. Ernst, Kai Zheng, An Song, Siddharth Sukumaran, Julien Lafrance-Vanasse, Van Nguyen, Devin Tesar, Rong Deng, Greg A. Lazar
Publikováno v:
mAbs. 11:942-955
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd5cc1f2d9b349c5ce6517191eeda48
https://doi.org/10.1080/19420862.2019.1605270
https://doi.org/10.1080/19420862.2019.1605270
Autor:
Julien Lafrance-Vanasse, Mason J. Appel, Hyeongtaek Lim, Carolyn R. Bertozzi, Chi Lin Tsai, John A. Tainer, Katlyn K. Meier, Britt Hedman, Edward I. Solomon, Keith O. Hodgson
Publikováno v:
Proceedings of the National Academy of Sciences. 116:5370-5375
The formylglycine-generating enzyme (FGE) is required for the posttranslational activation of type I sulfatases by oxidation of an active-site cysteine to C α -formylglycine. FGE has emerged as an enabling biotechnology tool due to the robust utilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9bf00a1e0426ecfeea9735473642e7
https://doi.org/10.1073/pnas.1818274116
https://doi.org/10.1073/pnas.1818274116
Autor:
Gautham K. Rao, Stephen P. Schauer, Edmond Teng, Joseph Bravo, Reina N. Fuji, Andrea Pfeifer, Yong Ying, Kimberly Scearce-Levie, Jessica Couch, Hilda Solanoy, Paul T. Manser, Andreas Muhs, Han Lin, Daniela Bumbaca Yadav, Oded Foreman, Dongping He, James A. Ernst, Flavia Brunstein, Hai Ngu, Michael C. M. Kwok, Maria Pihlgren, Oskar Adolfsson, Mira Blendstrup, William B. Smith, Priya Chandra, Akash Datwani, Michael Keeley, Danielle DiCara, Robert Brendza, Yanmei Lu, Julien Lafrance-Vanasse, Corinne Foo-Atkins, Jasvinder K. Atwal, Isidro Hötzel, Seung-Hye Lee, Kristin R. Wildsmith, Ruby Chan, Helen Booler, Rich Erickson, Barthélemy Demeule, Geoffrey A. Kerchner, Wilman Luk, Gai Ayalon
Publikováno v:
Science Translational Medicine. 13
Tau has become an attractive alternative target for passive immunotherapy efforts for Alzheimer's disease (AD). The anatomical distribution and extent of tau pathology correlate with disease course and severity better than other disease markers to da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8226f0212aa58c81fd5ec5abd2b2f7
https://doi.org/10.1126/scitranslmed.abb2639
https://doi.org/10.1126/scitranslmed.abb2639
Autor:
Shan, Chung, Van, Nguyen, Yuwen Linda, Lin, Julien, Lafrance-Vanasse, Suzie J, Scales, Kevin, Lin, Rong, Deng, Kathi, Williams, Gizette, Sperinde, Juan Jenny, Li, Kai, Zheng, Siddharth, Sukumaran, Devin, Tesar, James A, Ernst, Saloumeh, Fischer, Greg A, Lazar, Saileta, Prabhu, An, Song
Publikováno v:
mAbs
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b24934924be00d9ba5b5fc66744542b7
https://pubmed.ncbi.nlm.nih.gov/30982394
https://pubmed.ncbi.nlm.nih.gov/30982394
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O
Autor:
Mason J, Appel, Katlyn K, Meier, Julien, Lafrance-Vanasse, Hyeongtaek, Lim, Chi-Lin, Tsai, Britt, Hedman, Keith O, Hodgson, John A, Tainer, Edward I, Solomon, Carolyn R, Bertozzi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(12)
The formylglycine-generating enzyme (FGE) is required for the posttranslational activation of type I sulfatases by oxidation of an active-site cysteine to C(α)-formylglycine. FGE has emerged as an enabling biotechnology tool due to the robust utilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0633c33169343265d07d7e8650615c8
https://pubmed.ncbi.nlm.nih.gov/30824597
https://pubmed.ncbi.nlm.nih.gov/30824597
Autor:
Nicholas Vance, Neelie Zacharias, Mark Ultsch, Guangmin Li, Aimee Fourie, Peter Liu, Julien LaFrance-Vanasse, James A. Ernst, Wendy Sandoval, Katherine R. Kozak, Gail Phillips, Weiru Wang, Jack Sadowsky
Publikováno v:
Bioconjugate chemistry. 30(1)
Site-specific conjugation of small molecules to antibodies represents an attractive goal for the development of more homogeneous targeted therapies and diagnostics. Most site-specific conjugation strategies require modification or removal of antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ca2f0a00e1caf74a5840b230121d29
https://pubmed.ncbi.nlm.nih.gov/30566343
https://pubmed.ncbi.nlm.nih.gov/30566343
Autor:
Julien Lafrance-Vanasse, Peter Liu, Gai Ayalon, Seung-Hye Lee, Maria Pihlgren, Paul Auger, Oskar Adolfsson, James A. Ernst, Thomas G. Beach, Lorianne Rey-Bellet, Marcel P. van der Brug, Andrea Pfeifer, Hsu-Hsin Chen, Brad A. Friedman, Andreas Muhs, Kristin R. Wildsmith
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
The aggregation of intracellular tau protein is a major hallmark of Alzheimer’s disease (AD). The extent and the stereotypical spread of tau pathology in the AD brain are correlated with cognitive decline during disease progression. Here we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980efe258a07eea69778e02406c67e37
https://pubmed.ncbi.nlm.nih.gov/30425303
https://pubmed.ncbi.nlm.nih.gov/30425303
Publikováno v:
DNA Repair. 19:95-107
To avoid genome instability, DNA repair nucleases must precisely target the correct damaged substrate before they are licensed to incise. Damage identification is a challenge for all DNA damage response proteins, but especially for nucleases that cut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a11e1a0a7430a563d85c5e373b6955
https://doi.org/10.1016/j.dnarep.2014.03.022
https://doi.org/10.1016/j.dnarep.2014.03.022
Autor:
Geneviève Arseneault, James G. Omichinski, Luca Raiola, Mathieu Lussier-Price, Jacques Archambault, Julien Lafrance-Vanasse, Xavier H. Mascle, David R. Gagnon, Pascale Legault
Publikováno v:
Structure. 21(11):2014-2024
SummaryLike other acidic transactivation domains (TAD), the minimal TAD from the erythroid-specific transcription factor EKLF (EKLFTAD) has been shown to contribute both to its transcriptional activity as well as to its ubiquitin(UBI)-mediated degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9edcba4585cb71e732d97c640ac515