Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Julien Guizetti"'
Autor:
Vanessa S Stürmer, Sophie Stopper, Patrick Binder, Anja Klemmer, Nicolas P Lichti, Nils B Becker, Julien Guizetti
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011807 (2023)
Malaria is caused by the rapid proliferation of Plasmodium parasites in patients and disease severity correlates with the number of infected red blood cells in circulation. Parasite multiplication within red blood cells is called schizogony and occur
Externí odkaz:
https://doaj.org/article/57c3e9705a3d4c2db08ef00bed8ccc9c
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011899 (2023)
Centrins are small calcium-binding proteins that have a variety of roles and are universally associated with eukaryotic centrosomes. Rapid proliferation of the malaria-causing parasite Plasmodium falciparum in the human blood depends on a particularl
Externí odkaz:
https://doaj.org/article/e1a1fe1a26674f4eae93328713ad16ca
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Plasmodium falciparum proliferates through schizogony in the clinically relevant blood stage of infection. During schizogony, consecutive rounds of DNA replication and nuclear division give rise to multinucleated stages before cellularizatio
Externí odkaz:
https://doaj.org/article/d7fd611e5ef744ceaaa3ebb9c71b5913
Autor:
Christoph Wenz, Caroline Sophie Simon, Tatiany Patricia Romão, Vanessa Saskia Stürmer, Marta Machado, Natacha Klages, Anja Klemmer, Yannik Voß, Markus Ganter, Mathieu Brochet, Julien Guizetti
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011325 (2023)
Malaria-causing parasites achieve rapid proliferation in human blood through multiple rounds of asynchronous nuclear division followed by daughter cell formation. Nuclear divisions critically depend on the centriolar plaque, which organizes intranucl
Externí odkaz:
https://doaj.org/article/510d636df35b43d79360a36d0d69a199
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3 (2023)
Malaria remains a significant threat to global health, and despite concerted efforts to curb the disease, malaria-related morbidity and mortality increased in recent years. Malaria is caused by unicellular eukaryotes of the genus Plasmodium, and all
Externí odkaz:
https://doaj.org/article/324664a2361543aa9b3a563da9ce356e
Autor:
Komal Soni, Georg Kempf, Karen Manalastas-Cantos, Astrid Hendricks, Dirk Flemming, Julien Guizetti, Bernd Simon, Friedrich Frischknecht, Dmitri I. Svergun, Klemens Wild, Irmgard Sinning
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
The SRP Alu domain is involved in co-translational protein targeting. Soni et al. investigate the Alu domain of Plasmodium falciparum, the agent of malaria, and find that unlike any other it adopts an open conformation.
Externí odkaz:
https://doaj.org/article/209bda6b89384eceb72f2290525335c3
Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence.
Autor:
Mathias Diehl, Lena Roling, Lukas Rohland, Sebastian Weber, Marek Cyrklaff, Cecilia P Sanchez, Carlo A Beretta, Caroline S Simon, Julien Guizetti, Julia Hahn, Norma Schulz, Matthias P Mayer, Jude M Przyborski
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009969 (2021)
The pathology associated with malaria infection is largely due to the ability of infected human RBCs to adhere to a number of receptors on endothelial cells within tissues and organs. This phenomenon is driven by the export of parasite-encoded protei
Externí odkaz:
https://doaj.org/article/ad3aa796df9c4134ab9f7afc1411acec
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Regulating the number of progeny generated by replicative cell cycles is critical for any organism to best adapt to its environment. Classically, the decision whether to divide further is made after cell division is completed by cytokinesis and can b
Externí odkaz:
https://doaj.org/article/e77dcd91a6a049d28955ce915c14ae19
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001105 (2021)
Apicomplexan parasites are defined by complex apical structures, which are necessary for interaction with incredibly diverse host cells. Two studies now amend a long-standing paradigm by showing conservation of an essential ring structure in the enti
Externí odkaz:
https://doaj.org/article/a7ce172d931c403a8bb075245e2c998a
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The human malaria parasite Plasmodium falciparum uses mutually exclusive expression of the PfEMP1-encoding var gene family to evade the host immune system. Despite progress in the molecular understanding of the default silencing mechanism, t
Externí odkaz:
https://doaj.org/article/03d722d0147f412f860ff784e5a0530e