Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Julien Genovino"'
Autor:
Yajing Lian, Nat Monck, Julien Genovino, Thomas Sheridan, Hatice G. Yayla, Jonathan W. Burton
Publikováno v:
European Journal of Organic Chemistry. 2020:2766-2770
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1666729d8b0ba97e3cb3155bf1add0b2
https://doi.org/10.1002/ejoc.202000337
https://doi.org/10.1002/ejoc.202000337
Autor:
Liuqing Wei, Jun Xiao, Joseph S. Warmus, Jeffrey R. Chabot, Robert Dullea, Christopher T. Salatto, David W. Piotrowski, Benjamin A. Thuma, Donna N. Petersen, Chris Limberakis, Julien Genovino, Steven B. Coffey, Michael W. Bolt, Kim F. McClure, Kevin D. Hesp, Spiros Liras, Jamie H. D. Cate, Nathanael G. Lintner, Allyn T. Londregan, Gary Erik Aspnes, Benjamin Reidich
Publikováno v:
Journal of Medicinal Chemistry. 61:5704-5718
The optimization of a new class of small molecule PCSK9 mRNA translation inhibitors is described. The potency, physicochemical properties, and off-target pharmacology associated with the hit compound (1) were improved by changes to two regions of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46075104e513dd56e96e55dc41b689b9
https://doi.org/10.1021/acs.jmedchem.8b00650
https://doi.org/10.1021/acs.jmedchem.8b00650
Autor:
Mathieu Frenette, Gajendrasingh K. Ingle, Yuan Zhang, Taylor O. Hope, Julien Genovino, Antoine Juneau, Yajing Lian, Yohann Gagné
Publikováno v:
Organic Letters. 20:3229-3232
A metal-free photoredox C-H alkylation of heteroaromatics from readily available carboxylic acids using an organic photocatalyst and hypervalent iodine reagents under blue LED light is reported. The developed methodology tolerates a broad range of fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cc5b5836462d54ab138cf27fce981e
https://doi.org/10.1021/acs.orglett.8b01085
https://doi.org/10.1021/acs.orglett.8b01085
Autor:
Bruce M. Bechle, Joseph S. Warmus, Jianmin Sun, David C. Blakemore, Chunhui Dai, Chan Woo Huh, Julien Genovino, Colin R. Rose, Matthew Corbett
Publikováno v:
Organic Letters. 19:1064-1067
A three-component, titanium-mediated synthesis of α-branched N-acylamines from commercial or readily accessible amides, aldehydes, and organometallic reagents is reported. The transformation proceeds under mild reaction conditions and tolerates a va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ed4ffa313be71189d1fd7a91352ee2
https://doi.org/10.1021/acs.orglett.7b00082
https://doi.org/10.1021/acs.orglett.7b00082
Publikováno v:
Angewandte Chemie. 128:14430-14451
Konnen klassische und moderne C-H-Oxidationsreaktionen Biotransformationen bei der Synthese von Wirkstoffmetaboliten erganzen? Wir haben versucht, bei einer Durchsicht der Literatur eine Antwort auf diese wichtige Frage fur die Praxis der pharmazeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78cb215bed1becae33e0cd4b670f3a6a
https://doi.org/10.1002/ange.201602644
https://doi.org/10.1002/ange.201602644
Publikováno v:
Tetrahedron Letters. 56:3066-3069
We aim the power of C–H bond functionalization at a problem of major practical consequence—namely, scalable access to drug metabolites and their analogs. In this context, we pursue the development of simple C–H oxidation methods that tolerate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c429f262fa85e8b6f3246df2bedfe44
https://doi.org/10.1016/j.tetlet.2014.11.037
https://doi.org/10.1016/j.tetlet.2014.11.037
Autor:
Louise Bernier, Gary Chinigo, Chulho Choi, Julien Genovino, Mark W. Bundesmann, Mathieu Frenette, Olugbeminiyi O. Fadeyi, Yohann Gagné, Neal W. Sach, Martins S. Oderinde, Antoine Juneau, Philippe Nuhant, Bhagyashree Khunte, Christophe Allais, Yvette M. Fobian
Publikováno v:
Angewandte Chemie (International ed. in English). 56(48)
A visible-light-driven Minisci protocol that employs an inexpensive earth-abundant metal catalyst, decacarbonyldimanganese Mn2 (CO)10 , to generate alkyl radicals from alkyl iodides has been developed. This Minisci protocol is compatible with a wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18494db170c7fa126bd9911a752ce461
https://pubmed.ncbi.nlm.nih.gov/28960645
https://pubmed.ncbi.nlm.nih.gov/28960645
Publikováno v:
ChemInform. 47
Can classical and modern chemical C-H oxidation reactions complement biotransformation in the synthesis of drug metabolites? We have surveyed the literature in an effort to try to answer this important question of major practical significance in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79ba25696be2a5998a1170996773fbb
https://doi.org/10.1002/chin.201651252
https://doi.org/10.1002/chin.201651252
Autor:
Julien Genovino, Victor Snieckus
Publikováno v:
Synfacts. 11:0583-0585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62758153e6f05df3e37f89498db1f669
https://doi.org/10.1055/s-0034-1380832
https://doi.org/10.1055/s-0034-1380832
Publikováno v:
Journal of the American Chemical Society. 135:12346-12352
The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b357bb64733f195bf519ebccbcd6dd3
https://doi.org/10.1021/ja405471h
https://doi.org/10.1021/ja405471h