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pro vyhledávání: '"Julien Gagneron"'
Publikováno v:
European Journal of Organic Chemistry. 2006:4891-4897
We report on the synthesis of hitherto unknown pyrimidine nucleoside analogues bearing the 2-oxabicyclo[3.1.0]hexane scaffold (5, 6, 8, 13–17 and 19) with various modifications at the C-4′ position including methylene, azido, and arabino-like con
Autor:
Dae Hong Shin, Gilles Gosselin, Kenneth A. Jacobson, Christophe Mathé, Pedro Besada, Julien Gagneron, Savitri Maddileti, Stefano Costanzi, T. Kendall Harden, Hyojin Ko
Publikováno v:
Journal of Medicinal Chemistry. 49:5532-5543
The structure-activity relationships and molecular modeling of the uracil nucleotide activated P2Y6 receptor have been studied. Uridine 5'-diphosphate (UDP) analogues bearing substitutions of the ribose moiety, the uracil ring, and the diphosphate gr
Synthesis and study of conformationally restricted 3'-deoxy-3',4'-exo-methylene nucleoside analogues
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 24(5-7)
Hitherto unknown restricted 3'-deoxy-3',4'-exo-methylene nucleoside derivatives bearing the nucleic acid naturally occurring pyrimidine bases have been synthesized. The compounds were tested for their activity against HIV, HBV, and several RNA viruse