Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Julien Dugal-Tessier"'
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:201-211
Auristatins are important payloads used in antibody drug conjugates (ADCs), and the most well-known compound family member, monomethyl auristatin (MMAE), is used in two Food and Drug Administration (FDA)-approved ADCs, Adcetris® and Polivy®. Multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c536cbdb12e48898f559345c388d15b4
https://doi.org/10.1248/cpb.c19-00853
https://doi.org/10.1248/cpb.c19-00853
Autor:
Julien Dugal-Tessier, Nareshkumar Jain
Publikováno v:
Chemical Linkers in Antibody–Drug Conjugates (ADCs) ISBN: 9781839162633
Often overlooked, non-cleavable linkers are an important tool in antibody–drug conjugate (ADC) discovery. This chapter discusses the use of non-cleavable linkers in the context of ADCs. Non-cleavable linkers have the advantage of being able to modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6f966bb5fb056651bf351c2e2fb831
https://doi.org/10.1039/9781839165153-00136
https://doi.org/10.1039/9781839165153-00136
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 838, p 838 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine
A summary of the key technological advancements in the preparation of antibody–oligonucleotide conjugates (AOCs) and the distinct advantages and disadvantages of AOCs as novel therapeutics are presented. The merits and demerits of the different app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b5588e16fb2ae8901d2b7d4cd643da
https://www.mdpi.com/2077-0383/10/4/838
https://www.mdpi.com/2077-0383/10/4/838
Publikováno v:
Journal of Natural Products. 80:2484-2491
Synthetic analogues of the natural occurring dolastatin 10 are of great interest in cancer due to their potent in vitro activity and their uses as payloads in antibody drug conjugates (ADCs). Modification of the dolastatin 10 core scaffold has mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fc03ba1ea09bffba93d2bdb9349cd8
https://doi.org/10.1021/acs.jnatprod.7b00359
https://doi.org/10.1021/acs.jnatprod.7b00359
Autor:
Akihiro Okada, Julien Dugal-Tessier, Maria-Christina Malinao, Brian A. Mendelsohn, John E Atkinson, Banmeet Anand, Josh Snyder
Publikováno v:
Molecular pharmaceutics. 15(6)
AGS62P1 is an antibody drug conjugate (ADC) composed of a human IgG1κ monoclonal antibody against FLT3 (FMS-like tyrosine kinase 3) with a p-acetyl phenylalanine (pAF) residue inserted at position 124 of each heavy chain linked to the proprietary mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1372f3e24e4dc019e557049158afe79d
https://pubmed.ncbi.nlm.nih.gov/29757653
https://pubmed.ncbi.nlm.nih.gov/29757653
Autor:
Jennifer M. Dodd, Julien Dugal-Tessier, Stuart Daniel Barnscher, Brian A. Mendelsohn, Zili An, Josh Snyder
Publikováno v:
Bioconjugate chemistry. 28(2)
Antibody drug conjugates offer a targeted cancer treatment for the delivery of potent cytotoxic drugs. Derivatives of the natural product dolastatin 10 containing pyridines and other basic amines were examined with the objective of determining if a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94284464fb1d946d575adc77a0878c63
https://pubmed.ncbi.nlm.nih.gov/28060485
https://pubmed.ncbi.nlm.nih.gov/28060485
Publikováno v:
Asymmetric Synthesis II: More Methods and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a69d5a6b9355882a00040808842899
https://doi.org/10.1002/9783527652235.ch39
https://doi.org/10.1002/9783527652235.ch39
Publikováno v:
Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis. :321-341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439b0564259631fa77c14b8c0a2084c3
https://doi.org/10.1002/9781118299715.ch10
https://doi.org/10.1002/9781118299715.ch10
Autor:
Julien Dugal-Tessier, Elizabeth A. O'Bryan, Daniel T. Cohen, Karl A. Scheidt, Thomas Schroeder
Publikováno v:
Angewandte Chemie International Edition. 51:4963-4967
A cooperative catalysis approach for the enantioselective formal [3+2] addition of α,β-unsaturated aldehydes to isatins has been developed. The N-heterocyclic carbene (NHC)-catalyzed homoenolate annulations of β-aryl enals require the addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27458e15141059615923099f11087d2f
https://doi.org/10.1002/anie.201201643
https://doi.org/10.1002/anie.201201643
Publikováno v:
Heteroatom Chemistry. 21:355-360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98420cfdc23d4817f22cbd3bb791fc3d
https://doi.org/10.1002/hc.20619
https://doi.org/10.1002/hc.20619