Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Julien Dilly"'
Autor:
Silvia Coma, Monica Musteanu, Cristina Caffarra, Alessia Mira, Enrico Patrucco, Julien Dilly, Andrew J. Aguirre, Mariano Barbacid, Chiara Ambrogio, Jonathan A. Pachter
Publikováno v:
Molecular Cancer Research. 21:B025-B025
KRAS is the most frequently mutated RAS family member. Within non-small cell lung cancer (NSCLC), G12C is the most prevalent KRAS mutation (~13%) and the KRAS G12C inhibitors (G12Ci) sotorasib and adagrasib are now FDA approved. However, it has been
Autor:
Jimmy A. Guo, Jennifer Su, Carina Shiau, Ananya Jambhale, Annan Yang, Westley Wu, Junning Wang, Connor Hennessey, Patrick Yu, Brendan Parent, Giselle Uribe, Julien Dilly, Laleh Abbassi, Qijia Yu, Arnav Mehta, David Ting, Brian Wolpin, William Freed-Pastor, Joseph Mancias, Tyler Jacks, William L. Hwang, Andrew J. Aguirre
Publikováno v:
Cancer Research. 83:5775-5775
Pancreatic cancer is a challenging disease which lacks a robust precision oncology framework. Prior work has demonstrated that transcriptional subtypes in pancreatic cancer can stratify patients by response to chemotherapy and overall survival. These
Autor:
Harshabad Singh, Rachel B. Keller, Kevin S. Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Eizabeth Cohen, Michael Tolstorukov, Emma Hill, Elizabeth Andrews, Lauren K. Brais, Annacarolina Da Silva, Kimberly Perez, Douglas A. Rubinson, Benjamin L. Schlechter, Michael H. Rosenthal, Jason L. Hornick, Valentina Nardi, Yvonne Li, Hersh Gupta, Andrew Cherniack, Mathew L. Meyerson, James M. Cleary, Jonathan A. Nowak, Brian M. Wolpin, Andrew A. Aguirre
Publikováno v:
Cancer Research. 82:A001-A001
Approximately 8-10% of pancreatic cancers do not harbor mutations in KRAS. Understanding the unique molecular and clinical features of this subset of pancreatic cancer (PC) is important to guide patient stratification for clinical trials of molecular
Autor:
Jimmy A. Guo, Jennifer Su, Ananya Jambhale, Julien Dilly, Connor J. Hennessey, Carina Shiau, Patrick Yu, Steven Wang, Junning Wang, Laleh Abbassi, James Neiswender, Tate Bertea, Annan Yang, Qijia Yu, Peter Westcott, Jason Schenkel, Daniel Y. Kim, Hannah I. Hoffman, Grissel Cervantes Jaramillo, Giselle A. Uribe, Westley W. Wu, Arnav Mehta, David Ting, Julian A. Pacheco, Amy Deik, Clary Clish, Francisca Vazquez, Brian Wolpin, Aviv Regev, William A. Freed-Pastor, Joseph D. Mancias, Tyler Jacks, William L. Hwang, Andrew J. Aguirre
Publikováno v:
Cancer Research. 82:A052-A052
Transcriptional states in pancreatic cancer can stratify patients by response to chemotherapy and clinical outcomes. These include the classical and basal-like states as well as a newly identified neural-like progenitor (NRP) state, which we have pre
Autor:
Lee P. Lim, Julie Wiese, Alexa B. Schrock, James G. Christensen, Melissa Lynne Johnson, Kevin M. Haigis, Andrew J. Aguirre, Kavita Garg, Hanrong Feng, Viola W. Zhu, Kathryn C. Arbour, Nicole S. Persky, Gregory J. Riely, Joseph O. Jacobson, Shengwu Liu, Tejas Patil, Mark M. Awad, Julien Dilly, Sai-Hong Ignatius Ou, Mark Li, Jason Christiansen, Lynette M. Sholl, Piro Lito, Peter D. Olson, Shannon S. Zhang, J. David Lawson, Jessica J. Y. Lee, Rebecca S. Heist, Kristen E. Lowder, Xiaoping Yang, Laura Waters, David E. Root, Igor I. Rybkin, Lars D. Engstrom, Brian M. Wolpin, Pasi A. Jänne, Yin P Hung
Publikováno v:
N Engl J Med
BACKGROUND: Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRAS(G12C)). The mechanisms of acquired resistance to these t
Autor:
Silvia Coma, Sanjib Chowdhury, Julien Dilly, Monica Musteanu, Mariano Barbacid, Andrew J. Aguirre, Jonathan A. Pachter
Publikováno v:
Cancer Research. 82:402-402
KRAS G12C inhibitors (G12Ci), sotorasib and adagrasib, have demonstrated antitumor activity in patients with KRAS G12C mutant (mt) non-small cell lung cancer (NSCLC), and sotorasib has recently received FDA approval. It has been shown that simultaneo
Autor:
Laura Waters, Melissa Lynne Johnson, Kavita Garg, Lars D. Engstrom, Mark M. Awad, Pasi A. Jänne, Xiaoping Yang, Sai-Hong Inatius Ou, Mark Li, Andrew J. Aguirre, Gregory J. Riely, Viola W. Zhu, Kathryn C. Arbour, Julien Dilly, David E. Root, Rebecca S. Heist, Nicole S. Persky, Lynette M. Sholl, Lee Lim, J. David Lawson, Piro Lito, Shengwu Liu, Peter D. Olson, Joseph O. Jacobson, Tejas Patil, James J. Christensen
Publikováno v:
Cancer Research. 81:LB002-LB002
Background: KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRASG12C) occur in ~13% of non-small cell lung cancers (NSCLC), ~3% of colorectal cancers (CRC), and less commonly in other cancer types. In early phase clinical trials of pat
Publikováno v:
Journal of cell science. 133(1)
Mechanical cues are essential for the regulation of cell and tissue physiology. Hence, it has become an utmost necessity for cell biologists to account for those mechanical parameters when investigating biological processes and they need devices to m