Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Julien Dheur"'
Autor:
Emmanuelle Boll, Oleg Melnyk, Nathalie Ollivier, Hervé Drobecq, Julien Dheur, Laurent Raibaut, Rémi Desmet, Reda Mhidia, Annick Blanpain, Silvain L. Pira
Publikováno v:
Journal of Peptide Science. 20:92-97
Protein total chemical synthesis enables the atom-by-atom control of the protein structure and therefore has a great potential for studying protein function. Native chemical ligation of C-terminal peptide thioesters with N-terminal cysteinyl peptides
Autor:
Oleg Melnyk, Hervé Drobecq, Julien Dheur, Laurent Raibaut, Emmanuelle Boll, Silvain L. Pira, O. El Mahdi
Publikováno v:
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2016, 14 (30), pp.7211-7216. ⟨10.1039/c6ob01079b⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2016, 14 (30), pp.7211-7216. ⟨10.1039/c6ob01079b⟩
Organic & Biomolecular Chemistry, 2016, 14 (30), pp.7211-7216. ⟨10.1039/c6ob01079b⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2016, 14 (30), pp.7211-7216. ⟨10.1039/c6ob01079b⟩
The bis(2-sulfanylethyl)amide (SEA) N,S-acyl shift thioester surrogate has found a variety of useful applications in the field of protein total synthesis. Here we present novel insights into the SEA amide/thioester equilibrium in water which is an es
Publikováno v:
Organic Letters. 14:2222-2225
Bis(2-sulfanylethyl)amido (SEA) side-chain derivatives of aspartic and glutamic acids enable the synthesis of tail-to-side chain cyclic or branched peptides using standard Fmoc-SPPS followed by SEA native peptide ligation.
Publikováno v:
Organic Letters. 13:1560-1563
Thiazolidine thioester peptides were synthesized by reacting bis(2-sulfanylethyl)amido peptides with glyoxylic acid at pH 1. A significant increase in Native Chemical Ligation (NCL) rate was observed with thiazolidine thioesters compared to 3-mercapt
Publikováno v:
Advanced Synthesis & Catalysis. 352:557-561
The rhodium-catalysed carbonylative addition of arylboronic acids to propargylic alcohols yields gamma-hydroxy enones that are readily cyclised through a dehydration step to the corresponding furan analogues. The transformation was improved thanks to
Publikováno v:
Synlett. 2009:1745-1748
The carbonylative cross-coupling of potassium vinyl trifluoroborate or 2,4,6-trivinyltricycloboroxane with aryl iodides under mild conditions affords aryl vinyl ketones. The optimisation of the reaction conditions leads to the targeted enones in good
Publikováno v:
Advanced Synthesis & Catalysis. 349:2499-2506
The carbonylative addition of arylboronic acids to terminal alkynes under mild conditions affords (E)-α,β-unsaturated ketones with good yields. The reaction was achieved with chloro(1,5-cyclooctadiene)rhodium(I) dimer or chlorodicarbonylrhodium(I)
Autor:
Reda Mhidia, Julien Dheur, Annick Blanpain, Silvain L. Pira, Hervé Drobecq, Emmanuelle Boll, Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier, Rémi Desmet
Publikováno v:
ChemInform. 45
Protein total chemical synthesis enables the atom-by-atom control of the protein structure and therefore has a great potential for studying protein function. Native chemical ligation of C-terminal peptide thioesters with N-terminal cysteinyl peptides
Autor:
Nathalie, Ollivier, Laurent, Raibaut, Annick, Blanpain, Rémi, Desmet, Julien, Dheur, Reda, Mhidia, Emmanuelle, Boll, Hervé, Drobecq, Silvain L, Pira, Oleg, Melnyk
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 20(2)
Protein total chemical synthesis enables the atom-by-atom control of the protein structure and therefore has a great potential for studying protein function. Native chemical ligation of C-terminal peptide thioesters with N-terminal cysteinyl peptides
Autor:
Julien, Dheur, Nabil, Dendane, Rémi, Desmet, Fatima, Dahmani, Gauthier, Goormachtigh, Jérome, Vicogne, Véronique, Fafeur, Oleg, Melnyk
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 808
The interaction of polysaccharides with proteins modulates or triggers many biological effects. In particular, heparan sulphate proteoglycans (HSPGs) have multiple regulatory interactions with growth factors, enzymes, enzyme inhibitors, and some comp