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pro vyhledávání: '"Julien Desmarets"'
Publikováno v:
Biochemistry. 35:14868-14875
This paper defines the properties of interaction of endothelin-1 (Et-1) with cloned bovine ETA receptors. The Kd value of Et-1/ETA receptor complexes was estimated in membrane preparations to 20 pM using kinetic experiments and saturation experiments
Autor:
Julien Desmarets, Christian Frelin
Publikováno v:
Biochemical and biophysical research communications. 256(2)
Pharmacological evidence has suggested that endothelin-3 (ET-3) may act via a novel form of ET receptor that is shared by ETA receptor antagonists but not by ETB receptor selective agonists. This study analyses the properties of interaction of ET-3 w
Publikováno v:
Biochemical and biophysical research communications. 220(3)
[125I]Et-1 binding experiments showed the presence in rat brain capillary endothelial cells of typical ETA receptors that recognized Et-1, BQ-123 and FR139317 but not IRL1620, [Ala1,3,11,15]Et-1 or Et-3. [125I]Et-3 binding experiments showed that the