Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Julien Delezie"'
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtman, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. Here the authors show that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.
Externí odkaz:
https://doaj.org/article/444da6d136f045099a95445e8d650a04
Autor:
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pål O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101504- (2022)
Objective: Exercise is a critical component of a healthy lifestyle and a key strategy for the prevention and management of metabolic disease. Identifying molecular mechanisms underlying adaptation in response to chronic physical activity is of critic
Externí odkaz:
https://doaj.org/article/855b431c342f44e185149aa1a1055a2d
Autor:
Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition pres
Externí odkaz:
https://doaj.org/article/05a591c692df4b149c92e816d5905072
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtmann, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c879cf0cbe364394806d8ecf246c6dbb
Publikováno v:
Molecular Metabolism, Vol 5, Iss 7, Pp 580-588 (2016)
Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus. Key energy sensors, such as the AMP-activated protein
Externí odkaz:
https://doaj.org/article/120eddaad6604947b3f9875dfe99f4d2
Autor:
Julien Delezie, Christoph Handschin
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished tho
Externí odkaz:
https://doaj.org/article/6743247b3bc54cbeba56775c7641a402
Autor:
Christoph Handschin, Aurel B. Leuchtmann, Mihaela Zavolan, Julien Delezie, Anastasiya Börsch, Regula Furrer, Dominik Burri, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Thürkauf M, Shuo Lin, Michael Sinnreich, Alexander S. Ham, Markus A. Rüegg, Kathrin Chojnowska
As global life expectancy continues to climb, maintaining skeletal muscle function is increasingly essential to ensure a good life quality for aging populations. Calorie restriction (CR) is the most potent and reproducible intervention to extend heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a6cb405efb16d53c344bb20a9ee96f
Autor:
Julien Delezie, Carlos Henríquez-Olguín, Danilo Ritz, Volkan Adak, Elyzabeth Vargas-Fernández, Christoph Handschin, Konstantin Schneider-Heieck, Bettina Karrer-Cardel, Bastian Kohl, Joaquín Pérez-Schindler, Geraldine Maier, Sebastian Hiller, Alexander Schmidt, Aurel B. Leuchtmann, Thomas E. Jensen, Maria Hondele, Thomas Sakoparnig
Publikováno v:
Proc Natl Acad Sci U S A
Plasticity of cells, tissues, and organs is controlled by the coordinated transcription of biological programs. However, the mechanisms orchestrating such context-specific transcriptional networks mediated by the dynamic interplay of transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0228fb704973bea1c56b872a08aa34
https://doi.org/10.1073/pnas.2105951118
https://doi.org/10.1073/pnas.2105951118
Autor:
Christoph Handschin, Julien Delezie, Martin Weihrauch, Rocío Tejero, Geraldine Maier, Lucia Tabares, Markus A. Rüegg, Daniel J. Ham, Bettina Karrer-Cardel, Jonathan F. Gill
Publikováno v:
Proceedings of the National Academy of Sciences. 116:16111-16120
Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise, affects the development of the neuromuscular system. Besides its neuronal origin, BDNF is also a member of the myokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec080e6385cc13c9adb6eaf04a0f90f6
https://doi.org/10.1073/pnas.1900544116
https://doi.org/10.1073/pnas.1900544116
Autor:
Christoph Handschin, Gesa Santos, Julien Delezie, Pål O. Westermark, Danilo Ritz, Geraldine Maier
Key points Maximal endurance performance is greater in the early daytime. Timed exercise differentially alters the muscle transcriptome and (phospho)-proteome. Early daytime exercise triggers energy provisioning and tissue regeneration. Early night-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b982a9083146f251fdd0845995f8e0
https://edoc.unibas.ch/84236/
https://edoc.unibas.ch/84236/