Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Julien Defoiche"'
In vivo ribosomal RNA turnover is down-regulated in leukaemic cells in chronic lymphocytic leukaemia
Publikováno v:
British Journal of Haematology. 151:192-195
Autor:
Julien Defoiche, Derek C. Macallan, Ruth Pettengell, Luc Willems, Andrea Hegedus, Laurence Lagneaux, Yan Zhang
Publikováno v:
Clinical Chemistry. 55:1824-1833
Background: Most methods for estimation of rates of RNA production are not applicable in human in vivo clinical studies. We describe here an approach for measuring ribosomal RNA turnover in vivo using [6,6-2H2]-glucose as a precursor for de novo RNA
Autor:
Hala Ghattas, Julien Defoiche, Becca Asquith, Derek C. Macallan, Catherine de Lara, Yan Zhang, Peter C. L. Beverley
Publikováno v:
Nature Protocols. 4:1313-1327
Cell proliferation may be measured in vivo by quantifying DNA synthesis with isotopically labeled deoxyribonucleotide precursors. Deuterium-labeled glucose is one such precursor which, because it achieves high levels of enrichment for a short period,
Autor:
Amel Bouzar, Ruth Pettengell, Dominique Bron, Lucas Willems, Bernard Chatelain, Guy Berchem, Arsene Burny, Fenella Willis, Laurence Lagneaux, Christian Chatelain, Derek C. Macallan, Julien Defoiche, Mathieu Boxus
Publikováno v:
British Journal of Haematology. 144:41-52
Resistance to chemotherapy and drug toxicity are two major concerns of chronic lymphocytic leukaemia (B-CLL) treatment by purine nucleoside analogues (PNA, i.e. fludarabine and cladribine). We hypothesized that targeting epigenetic changes might addr
Autor:
Becca Asquith, Raymond Césaire, Amel Bouzar, Charles R. M. Bangham, Arsène Burny, Arnaud-Francois Florins, Stéphane Olindo, Luc Willems, Aissatou Signate, Julien Defoiche, Derek C. Macallan, Agnès Lézin, Gildas Belrose, Didier Smadja, Olivier Verlaeten, Nicolas Gillet
Publikováno v:
Frontiers in Bioscience. :205-215
HTLV-1 (human T-lymphotropic virus type 1) and BLV (bovine leukemia virus) are two related retroviruses infecting CD4+ and B lymphocytes in humans and ruminants, respectively. During infection, the host-pathogen interplay is characterized by very dyn
Publikováno v:
British Journal of Haematology. 145:426-428
In vivo ribosomal RNA turnover is down-regulated in leukaemic cells in chronic lymphocytic leukaemia
Publikováno v:
British journal of haematology. 151(2)
Publikováno v:
Leukemia research. 34(10)
Autor:
Ying Zhang, Dominique Bron, Laurence Lagneaux, Julien Defoiche, Derek C. Macallan, Lucas Willems, Christophe Debacq, Becca Asquith, Arsène Burny
Publikováno v:
British journal of haematology. 143(2)
Whether chronic lymphocytic leukaemia (CLL) is a latent or a proliferating disease has been intensively debated. Whilst the dogma that CLL results from accumulation of dormant lymphocytes is supported by the unresponsiveness of leukaemic cells to ant
Autor:
Amel Bouzar, Arsene Burny, Olivier Verlaeten, Richard Kettmann, Mathieu Boxus, Fabian Vandermeers, Roland Hubaux, Luc Willems, Julien Defoiche, Arnaud-Francois Florins
Publikováno v:
Veterinary immunology and immunopathology. 125(1-2)
Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in whic