Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in in vitro and in vivo Models of Neurodegenerative Diseases

Autor: Olfa Masmoudi-Kouki, Amira Namsi, Yosra Hamdi, Seyma Bahdoudi, Ikram Ghouili, Julien Chuquet, Jérôme Leprince, Benjamin Lefranc, Taoufik Ghrairi, Marie-Christine Tonon, Gérard Lizard, David Vaudry

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

Octadecaneuropeptide (ODN) and its precursor diazepam-binding inhibitor (DBI) are peptides belonging to the family of endozepines. Endozepines are exclusively produced by astroglial cells in the central nervous system of mammals, and their release is

Externí odkaz: https://doaj.org/article/99d17e4848f049d38f7b8410bd47c1a8

The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABAA Receptors, Boosts Functional Recovery after Stroke

Autor: Julien Chuquet, Andrew N. Clarkson, Ann-Britt Marcher, Katarzyna Gach-Janczak, Mahmoud Hazime, David Vaudry, Julie Maucotel, Katia Lehongre, Benjamin Lefranc, Pascale P. Quilichini, Raghavendra Y. Nagaraja, Emma K. Gowing, Susanne Mandrup, Rhita Lamtahri, Jérôme Leprince, Michael Alasoadura

Publikováno v: Lamtahri, R, Hazime, M, Gowing, E K, Nagaraja, R Y, Maucotel, J, Alasoadura, M, Quilichini, P P, Lehongre, K, Lefranc, B, Gach-Janczak, K, Marcher, A B, Mandrup, S, Vaudry, D, Clarkson, A N, Leprince, J & Chuquet, J 2021, ' The gliopeptide ODN, a ligand for the benzodiazepine site of GABA A receptors, boosts functional recovery after stroke ', Journal of Neuroscience, vol. 41, no. 33, pp. 7148-7159 . https://doi.org/10.1523/JNEUROSCI.2255-20.2021
Journal of Neuroscience
Journal of Neuroscience, 2021, 41 (33), pp.7148-7159. ⟨10.1523/JNEUROSCI.2255-20.2021⟩

Following stroke, the survival of neurons and their ability to re-establish connections is critical to functional recovery. This is strongly influenced by the balance between neuronal excitation and inhibition. In the acute phase of experimental stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25649e49dc0582c0ff69b132fd0af09a
https://doi.org/10.1523/jneurosci.2255-20.2021

The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABA

Autor: Rhita, Lamtahri, Mahmoud, Hazime, Emma K, Gowing, Raghavendra Y, Nagaraja, Julie, Maucotel, Michael, Alasoadura, Pascale P, Quilichini, Katia, Lehongre, Benjamin, Lefranc, Katarzyna, Gach-Janczak, Ann-Britt, Marcher, Susanne, Mandrup, David, Vaudry, Andrew N, Clarkson, Jérôme, Leprince, Julien, Chuquet

Publikováno v: J Neurosci

Following stroke, the survival of neurons and their ability to reestablish connections is critical to functional recovery. This is strongly influenced by the balance between neuronal excitation and inhibition. In the acute phase of experimental strok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73ce48738f195ea2403d2ab7dfbd8c76
https://pubmed.ncbi.nlm.nih.gov/34210784

Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study

Autor: Olivier Le Marec, Nicolas Chartrel, Jean A. Boutin, Hubert Vaudry, Jérôme Leprince, Christophe Dubessy, Cindy Neveu, Karima Alim, Marie Christine Picot, David Vaudry, Julien Chuquet, Benjamin Lefranc, Gaëtan Prévost

Publikováno v: Molecules
Molecules, MDPI, 2021, 26 (14), pp.4312. ⟨10.3390/molecules26144312⟩
Molecules, Vol 26, Iss 4312, p 4312 (2021)
Volume 26
Issue 14

26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of physiological processes including feeding behavior and glucose homeostasis. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de55e4482c5d8bff6d95294645479664
https://doi.org/10.3390/molecules26144312

Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies

Autor: Fabienne Dulin, Jérôme Leprince, Isabelle Ségalas-Milazzo, Hubert Vaudry, Ludovic Galas, Laure Guilhaudis, C Neveu, Ronan Bureau, Sylvain Rault, J. Sopková-de Oliveira Santos, Julien Chuquet, Benjamin Lefranc, C Calbrix, David Vaudry, Jean A. Boutin

Publikováno v: British Journal of Pharmacology. 171:4425-4439

Background and Purpose The neuropeptide 26RFa and its cognate receptor GPR103 are involved in the control of food intake and bone mineralization. Here, we have tested, experimentally, the predicted ligand-receptor interactions by site-directed mutage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9d16f153590a27e6f9b2e7fb80bc0a1
https://doi.org/10.1111/bph.12808