Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Julien Chapuis"'
Autor:
Charles Ellis, Natasha L. Ward, Matthew Rice, Neil J. Ball, Pauline Walle, Chloé Najdek, Devrim Kilinc, Jean-Charles Lambert, Julien Chapuis, Benjamin T. Goult
Publikováno v:
Open Biology, Vol 14, Iss 11 (2024)
Misprocessing of amyloid precursor protein (APP) is one of the major causes of Alzheimer’s disease. APP comprises a large extracellular region, a single transmembrane helix and a short cytoplasmic tail containing an NPxY motif (normally referred to
Externí odkaz:
https://doaj.org/article/e6eb5d9ad38545fba0cc5acd874a7f3c
Autor:
Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa, Pierre Dourlen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-23 (2022)
Abstract The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human BIN1 isoform1
Externí odkaz:
https://doaj.org/article/5a00e9ef0aa64aa8b839b112c52f6f26
Autor:
Florent Letronne, Geoffroy Laumet, Anne-Marie Ayral, Julien Chapuis, Florie Demiautte, Mathias Laga, Michel E. Vandenberghe, Nicolas Malmanche, Florence Leroux, Fanny Eysert, Yoann Sottejeau, Linda Chami, Amandine Flaig, Charlotte Bauer, Pierre Dourlen, Marie Lesaffre, Charlotte Delay, Ludovic Huot, Julie Dumont, Elisabeth Werkmeister, Franck Lafont, Tiago Mendes, Franck Hansmannel, Bart Dermaut, Benoit Deprez, Anne-Sophie Hérard, Marc Dhenain, Nicolas Souedet, Florence Pasquier, David Tulasne, Claudine Berr, Jean-Jacques Hauw, Yves Lemoine, Philippe Amouyel, David Mann, Rebecca Déprez, Frédéric Checler, David Hot, Thierry Delzescaux, Kris Gevaert, Jean-Charles Lambert
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 278-292 (2016)
Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amyloid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcripto
Externí odkaz:
https://doaj.org/article/b6a220c6a95c4d56a4492c3f25a412a8
Autor:
Lies Vanden Broeck, Marina Naval-Sánchez, Yoshitsugu Adachi, Danielle Diaper, Pierre Dourlen, Julien Chapuis, Gernot Kleinberger, Marc Gistelinck, Christine Van Broeckhoven, Jean-Charles Lambert, Frank Hirth, Stein Aerts, Patrick Callaerts, Bart Dermaut
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 160-172 (2013)
TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative disorders. Whether TDP-43 neurotoxicity is caused by a novel toxic gain-of-function mechanism of the aggregates or by a los
Externí odkaz:
https://doaj.org/article/1d9ad124cb184896bfed13eda1caab75
Autor:
Julien Chapuis, Didier Hannequin, Florence Pasquier, Peter Bentham, Alexis Brice, Isabelle Leber, Thierry Frebourg, Jean-François Deleuze, Emmanuelle Cousin, Uma Thaker, Philippe Amouyel, David Mann, Corinne Lendon, Dominique Campion, Jean-Charles Lambert
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 103-106 (2008)
The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE ɛ4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in thre
Externí odkaz:
https://doaj.org/article/6055dd300d734c18aa0d4ae2dbebbdb7
Autor:
Faiza Bensemain, Julien Chapuis, Jinzhou Tian, Jing Shi, Uma Thaker, Corinne Lendon, Takeshi Iwatsubo, Philippe Amouyel, David Mann, Jean-Charles Lambert
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 3, Pp 691-693 (2006)
Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorph
Externí odkaz:
https://doaj.org/article/458ebfae83424baba1d018cfd75b5d3c
Autor:
Audrey Coulon, Tiago Mendes, Devrim Kilinc, Julie Dumont, Julien Chapuis, Jean‐Charles Lambert
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e44728169256520323b4b331754209e8
https://doi.org/10.1002/alz.058660
https://doi.org/10.1002/alz.058660
Autor:
Deeya Saha, Charlotte Pain, Bushra Saeed Dohai, Bart Ghesquière, Franck Dequiedt, Christophe Desmet, Carmen López-Iglesias, Marc Thiry, Despoina Kerselidou, Pieter Van Vlierberghe, Jean-Charles Lambert, Kourosh Salehi-Ashtiani, Kyle J. Lauersen, Amnah Alzahmi, Marc Vidal, Pierre Lemaitre, Julien Hanson, Dae-Kyum Kim, Jean-Claude Twizere, Michael Herfs, Diana C. El Assal, Ashish Jaiswal, Sarah Daakour, Zahra Al Oula Hassoun, Marc A. M. J. van Zandvoort, Filip Matthijssens, Julien Olivet, Nicolas De Cock, Didier Vertommen, David R. Nelson, Julien Chapuis, Kèvin Knoops, Verena Kriechbaumer
Publikováno v:
SCIENCE ADVANCES
Science advances, 7(19):8349. American Association for the Advancement of Science
Science Advances
Science advances, 7(19):8349. American Association for the Advancement of Science
Science Advances
Integration of multiomics and imaging identifies a glycosyltransferase enzyme regulating endoplasmic reticulum sizes.
The endoplasmic reticulum (ER) is a central eukaryotic organelle with a tubular network made of hairpin proteins linked by hydr
The endoplasmic reticulum (ER) is a central eukaryotic organelle with a tubular network made of hairpin proteins linked by hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cf2a3f984622a740bd651cebe1c419
https://doi.org/10.1126/sciadv.abe8349
https://doi.org/10.1126/sciadv.abe8349
Autor:
Erwan Lambert, Bart Dermaut, Nicolas Barois, Julien Chapuis, Farida Adelfettah, Pierre Dourlen, Fabien Delahaye, Patrik Verstreken, Philippe Amouyel, Amélie Bonnefond, Xavier Hermant, Arnaud Carrier, Marcos Romualdo Costa, Cloé Dupont, Alexandre Pelletier, Orthis Saha, Lindsay Davoine, Jean-Charles Lambert, Ana Raquel Melo de Farias, Bruna Soares Landeira, Frank Lafont
SUMMARYThe Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human BIN1 isoform1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42f89e61f27f25556cd1daf3511ae6ef
https://doi.org/10.1101/2021.04.02.438184
https://doi.org/10.1101/2021.04.02.438184
Autor:
Tiago Mendes, Julie Dumont, Philippe Amouyel, Florie Demiautte, Fanny Eysert, Devrim Kilinc, Jean-Charles Lambert, AudreyAnais-Camille CoulonVreulx, Benjamin Grenier-Boley, Julien Chapuis, Amandine Flaig
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aada49ec6bcc974f3deba47f39e3e42
https://doi.org/10.1002/alz.041966
https://doi.org/10.1002/alz.041966