Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Julien Beyrath"'
Autor:
Aurelie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes, Monika A. Myszczynska, Elizabeth J. New, Julien Beyrath, Jan Smeitink, Laura Ferraiuolo, Heather Mortiboys
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Mutations in PRKN are the most common cause of early onset Parkinson’s disease. Parkin is an E3 ubiquitin ligase, functioning in mitophagy. Mitochondrial abnormalities are present in PRKN mutant models. Patient derived neurons are a promis
Externí odkaz:
https://doaj.org/article/5d11f9239fc34740ace065b8c2911136
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254315 (2021)
Aggressiveness of cancers, like prostate cancer, has been found to be associated with elevated expression of the microsomal prostaglandin E synthase-1 (mPGES-1). Here, we investigated whether KH176m (the active metabolite of sonlicromanol), a recentl
Externí odkaz:
https://doaj.org/article/66899fcd8dad41df877ed8c95e09000a
Autor:
Saskia Koene, Edwin Spaans, Luc Van Bortel, Griet Van Lancker, Brant Delafontaine, Fabio Badilini, Julien Beyrath, Jan Smeitink
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-12 (2017)
Abstract Background Mitochondrial disorders are a clinically, biochemically and genetically heterogeneous group of multi-system diseases, with an unmet medical need for treatment. KH176 is an orally bio-available small molecule under development for
Externí odkaz:
https://doaj.org/article/09fd79f686f64b96977b623d3acbd830
Autor:
Eligio F. Iannetti, Alessandro Prigione, Jan A. M. Smeitink, Werner J. H. Koopman, Julien Beyrath, Herma Renkema
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Mitochondria are best known as the powerhouses of the cells but their cellular role goes far beyond energy production; among others, they have a pivotal function in cellular calcium and redox homeostasis. Mitochondrial dysfunction is often associated
Externí odkaz:
https://doaj.org/article/e3e1a2d5e52b46e49283da5133ae443a
Autor:
Sarah Foriel, G. Herma Renkema, Yvonne Lasarzewski, Job Berkhout, Richard J. Rodenburg, Jan A. M. Smeitink, Julien Beyrath, Annette Schenck
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Mitochondrial diseases are a group of rare life-threatening diseases often caused by defects in the oxidative phosphorylation system. No effective treatment is available for these disorders. Therapeutic development is hampered by the high heterogenei
Externí odkaz:
https://doaj.org/article/60958f63847340fabe3853636624f7a5
Autor:
Werner JH Koopman, Julien Beyrath, Cheuk‐Wing Fung, Saskia Koene, Richard J Rodenburg, Peter HGM Willems, Jan AM Smeitink
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 4, Pp 311-327 (2016)
Abstract This review presents our current understanding of the pathophysiology and potential treatment strategies with respect to mitochondrial disease in children. We focus on pathologies due to mutations in nuclear DNA‐encoded structural and asse
Externí odkaz:
https://doaj.org/article/ffccdcbae0794df5bbe1c999a2b6c1f3
Autor:
Sarah Foriel, Julien Beyrath, Ilse Eidhof, Richard J. Rodenburg, Annette Schenck, Jan A. M. Smeitink
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 3 (2018)
Mitochondrial diseases are associated with a wide variety of clinical symptoms and variable degrees of severity. Patients with such diseases generally have a poor prognosis and often an early fatal disease outcome. With an incidence of 1 in 5000 live
Externí odkaz:
https://doaj.org/article/74ef7c04027e4f51804037e4c976c94f
Autor:
José Courty, Jean Paul Briand, Dominique Bagnard, Sylviane Muller, Alain Van Dorsselaer, Jean-Marc Strub, Gilles Carpentier, Marie Maurer, Patricia Albanese, Julien Beyrath, Panagiotis Katsoris, Charalampos Birmpas, Sophie Frechault, Olivier Chaloin, Valérie Machi, Yamina Hamma-Kourbali, Nicolas Page, Damien Destouches
Supplementary Figures 1-5, Tables 1-2, and Methods and Materials from A Simple Approach to Cancer Therapy Afforded by Multivalent Pseudopeptides That Target Cell-Surface Nucleoproteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7222b3e5b799e4d474a88ec2f96b67d
https://doi.org/10.1158/0008-5472.22391283.v1
https://doi.org/10.1158/0008-5472.22391283.v1
Autor:
Hinrich Gronemeyer, Gilles Guichard, Olivier Micheau, Sylvie Fournel, Wolfgang Maison, Miriam Wendland, Jean-Paul Briand, Marie-Charlotte Lechner, Alexandre Morizot, Christophe Pardin, Julien Beyrath, Valeria Pavet
Supplementary Figure 2 from Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c88e6a9615c2e71e63f1bdfc81610
https://doi.org/10.1158/0008-5472.22384586.v1
https://doi.org/10.1158/0008-5472.22384586.v1
Autor:
Hinrich Gronemeyer, Gilles Guichard, Olivier Micheau, Sylvie Fournel, Wolfgang Maison, Miriam Wendland, Jean-Paul Briand, Marie-Charlotte Lechner, Alexandre Morizot, Christophe Pardin, Julien Beyrath, Valeria Pavet
Supplementary Figure 3 from Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5652762e0c75397fb356e96fde3f52d7
https://doi.org/10.1158/0008-5472.22384583.v1
https://doi.org/10.1158/0008-5472.22384583.v1