Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Julien Bensalem"'
Autor:
Sanjna Singh, Julien Bensalem, Leanne K. Hein, Aaron Casey, Ville-Petteri Mäkinen, Timothy J. Sargeant
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract The efficient removal of apoptotic cells via efferocytosis is critical for maintaining optimal tissue function. This involves the binding and engulfment of apoptotic cells by phagocytes and the subsequent maturation of the phagosome, culmina
Externí odkaz:
https://doaj.org/article/db48dae77e834310a2649823011a623b
Autor:
Julien Bensalem, Leonie K. Heilbronn, Jemima R. Gore, Amy T. Hutchison, Timothy J. Sargeant, Célia Fourrier
Publikováno v:
BMC Nutrition, Vol 8, Iss 1, Pp 1-7 (2022)
Abstract Background Autophagy is a cellular process that cleanses cells and is particularly important during ageing. Autophagy has been extensively studied in vitro and in animal models and is known to be sensitive to nutrition. However, human data a
Externí odkaz:
https://doaj.org/article/5dcfed50bf8f4395a29d5a0c0c2c2a08
Autor:
Lauren S. Whyte, Célia Fourrier, Sofia Hassiotis, Adeline A. Lau, Paul J. Trim, Leanne K. Hein, Kathryn J. Hattersley, Julien Bensalem, John J. Hopwood, Kim M. Hemsley, Timothy J. Sargeant
Publikováno v:
IBRO Neuroscience Reports, Vol 12, Iss , Pp 131-141 (2022)
Lysosomal network abnormalities are an increasingly recognised feature of Alzheimer’s disease (AD), which appear early and are progressive in nature. Sandhoff disease and Tay-Sachs disease (neurological lysosomal storage diseases caused by mutation
Externí odkaz:
https://doaj.org/article/d1d4403666e2493b96517b7138797dcc
Publikováno v:
FEBS Open Bio, Vol 12, Iss 4, Pp 739-757 (2022)
Age‐related diseases represent some of the largest unmet clinical needs of our time. While treatment of specific disease‐related signs has had some success (for example, the effect of statin drugs on slowing progression of atherosclerosis), slowi
Externí odkaz:
https://doaj.org/article/3641831789a243cb958247775f9c99ce
Autor:
Miriam A. Lynn, Georgina Eden, Feargal J. Ryan, Julien Bensalem, Xuemin Wang, Stephen J. Blake, Jocelyn M. Choo, Yee Tee Chern, Anastasia Sribnaia, Jane James, Saoirse C. Benson, Lauren Sandeman, Jianling Xie, Sofia Hassiotis, Emily W. Sun, Alyce M. Martin, Marianne D. Keller, Damien J. Keating, Timothy J. Sargeant, Christopher G. Proud, Steve L. Wesselingh, Geraint B. Rogers, David J. Lynn
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109564- (2021)
Summary: Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of ea
Externí odkaz:
https://doaj.org/article/5b90d69fc8474a79a02b786fb67527aa
Biological Sensing of Nitric Oxide in Macrophages and Atherosclerosis Using a Ruthenium-Based Sensor
Autor:
Achini K. Vidanapathirana, Jarrad M. Goyne, Anna E. Williamson, Benjamin J. Pullen, Pich Chhay, Lauren Sandeman, Julien Bensalem, Timothy J. Sargeant, Randall Grose, Mark J. Crabtree, Run Zhang, Stephen J. Nicholls, Peter J. Psaltis, Christina A. Bursill
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1807 (2022)
Macrophage-derived nitric oxide (NO) plays a critical role in atherosclerosis and presents as a potential biomarker. We assessed the uptake, distribution, and NO detection capacity of an irreversible, ruthenium-based, fluorescent NO sensor (Ru-NO) in
Externí odkaz:
https://doaj.org/article/92a6c6d26440425d8b7ed0c79c53de6e
Autor:
Julien Bensalem, Stéphanie Dudonné, David Gaudout, Laure Servant, Frédéric Calon, Yves Desjardins, Sophie Layé, Pauline Lafenetre, Véronique Pallet
Publikováno v:
Journal of Nutritional Science, Vol 7 (2018)
Ageing is characterised by memory deficits, associated with brain plasticity impairment. Polyphenols from berries, such as flavan-3-ols, anthocyanins, and resveratrol, have been suggested to modulate synaptic plasticity and cognitive processes. In th
Externí odkaz:
https://doaj.org/article/dfd9caecce3d42c2800d5152869fdfca
Autor:
Julien Bensalem, Leanne K. Hein, Sofia Hassiotis, Paul J. Trim, Christopher G. Proud, Leonie K. Heilbronn, Timothy J. Sargeant
Publikováno v:
The Journal of Nutrition. 153:1407-1419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fdabd7b3dcd15eeb03c7322e4aad3ef
https://doi.org/10.1016/j.tjnut.2023.02.035
https://doi.org/10.1016/j.tjnut.2023.02.035
Autor:
Xiao Tong Teong, Kai Liu, Andrew D. Vincent, Julien Bensalem, Bo Liu, Kathryn J. Hattersley, Lijun Zhao, Christine Feinle-Bisset, Timothy J. Sargeant, Gary A. Wittert, Amy T. Hutchison, Leonie K. Heilbronn
Publikováno v:
Nature Medicine. 29:963-972
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47021814cd081a536539f614e2465e30
https://doi.org/10.1038/s41591-023-02287-7
https://doi.org/10.1038/s41591-023-02287-7
Autor:
Timothy J. Sargeant, Julien Bensalem
Publikováno v:
Trends in Molecular Medicine. 27:1091-1094
Preclinical research shows that autophagy is a modifiable process that holds promise for preventing human age-related disease. However, this knowledge has not been clinically translated. Here, we discuss recent developments in the ability to measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08764c55eb899824de7dcef0168b628f
https://doi.org/10.1016/j.molmed.2021.09.003
https://doi.org/10.1016/j.molmed.2021.09.003