Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Julien, Pothier"'
Autor:
Sébastien Jeay, Stefan Diethelm, Agnes Knopf, Marie Goxe, Marie Daugan, Julie Erupathil, Julien Pothier, Davide Pozzi, Thierry Sifferlen, Lorenza Wyder, Isabelle Lyothier, Olivier Corminboeuf, Francois Lehembre, Imke Renz, Dominique Meyer
Publikováno v:
Cancer Research. 83:1809-1809
Prostaglandin E2 (PGE2) binds to four G-protein-coupled EP receptors, of which both EP2 and EP4 are abundantly expressed by tumor-infiltrating immune cells including DCs, NK cells, Tregs, cytotoxic T cells and TAMs. Signaling via EP2 and EP4 is immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd9ab458e3dd16b1abdf96aeb71e613
https://doi.org/10.1158/1538-7445.am2023-1809
https://doi.org/10.1158/1538-7445.am2023-1809
Autor:
Sylvia Richard-Bildstein, Gabriel Schäfer, Laetitia Pouzol, Eleanor Lindenberg, François Lehembre, Hamed Aissaoui, Julien Pothier, Philippe Guerry, Carmela Gnerre
Publikováno v:
Journal of Medicinal Chemistry. 63:15864-15882
The chemokine receptor CXCR7, also known as ACKR3, is a seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies such as neurological diseases, autoimmune diseases, and cancers. By binding and scavenging the chemokines CX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be864ded7c823a1ef18d144d1aaa795
https://doi.org/10.1021/acs.jmedchem.0c01588
https://doi.org/10.1021/acs.jmedchem.0c01588
Autor:
Carina Lotz-Jenne, Sylvaine Cren, Christoph Joesch, Sabine Ackerknecht, Jennifer Brandes, Claire Moebs, Dominik Hartl, Felix Hartrampf, Philippe Guerry, Julien Pothier, Alexia Chavanton-Arpel
Publikováno v:
Cancer Immunology Research. 10:B66-B66
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) catalyze the oxidation of L-Tryptophan (TRP) leading to the formation of immunosuppressive kynurenine (KYN) pathway metabolites. According to TCGA, a substantial fraction of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f95478d5084597691f29d814a08334d4
https://doi.org/10.1158/2326-6074.tumimm22-b66
https://doi.org/10.1158/2326-6074.tumimm22-b66
Publikováno v:
Journal of Medicinal Chemistry. 58:8011-8035
Various racemic and enantioenriched (trans)-X,Y-dihydroxy-X,Y-dihydronaphthoyl analogues as well as X-hydroxy-naphthoyl analogues of CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (1, Setipiprant/A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8faf421d02c34572cac89017ca1e4a78
https://doi.org/10.1021/acs.jmedchem.5b00824
https://doi.org/10.1021/acs.jmedchem.5b00824
Autor:
Heinz Fretz, Xavier Leroy, Carmela Gnerre, Kurt Hilpert, Julien Pothier, Markus A. Riederer, Anja Valdenaire, Oliver Peter
Publikováno v:
Journal of Medicinal Chemistry. 56:4899-4911
Herein we describe the discovery of the novel CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid 28 (setipiprant/ACT-129968), a clinical development candidate for the treatment of asthma and seasonal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb4a02fb1da7aa0fe9fa9c3373a09ecd
https://doi.org/10.1021/jm400122f
https://doi.org/10.1021/jm400122f
Autor:
Markus A. Riederer, Anja Valdenaire, Heinz Fretz, Julien Pothier, Xavier Leroy, Carmela Gnerre, Oliver Peter, Dorte Renneberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:944-948
(E)-2-(3-(3-((3-Bromophenyl)amino)-2-cyano-3-oxoprop-1-en-1-yl)-1H-indol-1-yl)acetic acid (1) was discovered in a HTS campaign for CRTh2 receptor antagonists. An SAR around this hit could be established and representatives with interesting activity p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf39d537fa8ff71efe663ee5ee9d8c
https://doi.org/10.1016/j.bmcl.2012.12.050
https://doi.org/10.1016/j.bmcl.2012.12.050
Autor:
Heinz Fretz, Xavier Leroy, Carmela Gnerre, Markus A. Riederer, Anja Valdenaire, Oliver Peter, Julien Pothier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4660-4664
Hit-to-lead evolution of 2-(2-((2-(4-chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazol-1-yl)acetic acid (1), discovered in a high-throughput screening campaign as a novel chemotype of CRTh2 receptor antagonist, is presented. SAR development as well as in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202ca39c4ddd2d21f1345343cce8bbed
https://doi.org/10.1016/j.bmcl.2012.05.087
https://doi.org/10.1016/j.bmcl.2012.05.087
Publikováno v:
Tetrahedron. 60:3231-3241
A range of acidic Molecularly Imprinted Polymers (MIPs) were synthesised using the imprint molecule trans-carvyl amine as a transition state analogue for the selective isomerisation of alpha-pinene oxide to trans-carveol. The amine functionality of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954d69c668aaf916b4dc6a6eb5b73674
https://doi.org/10.1016/j.tet.2004.02.016
https://doi.org/10.1016/j.tet.2004.02.016
Publikováno v:
Tetrahedron Letters. 40:3701-3704
A highly convergent approach has been developed for the construction of various nitrogen heterocycles using as the key step the intermolecular addition of an α-ketonyl radical onto a suitably protected allylic or homoallylic amine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60b5b9bfddd05fbbea3fa541f7a089c6
https://doi.org/10.1016/s0040-4039(99)00592-4
https://doi.org/10.1016/s0040-4039(99)00592-4
Publikováno v:
ChemInform. 30
A highly convergent approach has been developed for the construction of various nitrogen heterocycles using as the key step the intermolecular addition of an α-ketonyl radical onto a suitably protected allylic or homoallylic amine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07de2fa47a34d96a69b39f5e4fa921ac
https://doi.org/10.1002/chin.199931176
https://doi.org/10.1002/chin.199931176